{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2026:GLOCE3H2COBIUK3L7FMEDTKC24","short_pith_number":"pith:GLOCE3H2","canonical_record":{"source":{"id":"2608.06998","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-08-07T09:17:13Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"549a4fdb95dd467b716244cfca76caf95b70e57f01146d973759dbe6b96ec2c1","abstract_canon_sha256":"d0886ac0db239a3c704d4a0021fdb8c74b7d779391a72d1444535544e4e7a911"},"schema_version":"1.0"},"canonical_sha256":"32dc226cfa13828a2b6bf95841cd42d732239f6424ca1e48eb1041cdb67007de","source":{"kind":"arxiv","id":"2608.06998","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2608.06998","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"arxiv_version","alias_value":"2608.06998v1","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2608.06998","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_12","alias_value":"GLOCE3H2COBI","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_16","alias_value":"GLOCE3H2COBIUK3L","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_8","alias_value":"GLOCE3H2","created_at":"2026-08-10T01:12:48Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2026:GLOCE3H2COBIUK3L7FMEDTKC24","target":"record","payload":{"canonical_record":{"source":{"id":"2608.06998","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-08-07T09:17:13Z","cross_cats_sorted":["physics.bio-ph"],"title_canon_sha256":"549a4fdb95dd467b716244cfca76caf95b70e57f01146d973759dbe6b96ec2c1","abstract_canon_sha256":"d0886ac0db239a3c704d4a0021fdb8c74b7d779391a72d1444535544e4e7a911"},"schema_version":"1.0"},"canonical_sha256":"32dc226cfa13828a2b6bf95841cd42d732239f6424ca1e48eb1041cdb67007de","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-08-10T01:12:48.095489Z","signature_b64":"ZUvMT4oMJ5PKl3kdMHED2RtQ2VYQl/bGbpBp6zLDiUhemiUpqSIPpPCYV1e80W+IV0ZDDQwXX26s7fVIjOspBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"32dc226cfa13828a2b6bf95841cd42d732239f6424ca1e48eb1041cdb67007de","last_reissued_at":"2026-08-10T01:12:48.092839Z","signature_status":"signed_v1","first_computed_at":"2026-08-10T01:12:48.092839Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2608.06998","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-08-10T01:12:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"k7EdhuCvbSgSjeaicFlF0+Ne1Y0YOPPj6PRBsVyeaM43HiNgJtqfKa6wqE5ikA2Rad4aHcBU4v2EF3yQQYHwBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T01:10:30.388226Z"},"content_sha256":"9b25d3a4d959495247911b9247f5d862a2942606f31007545673ae12c0650b60","schema_version":"1.0","event_id":"sha256:9b25d3a4d959495247911b9247f5d862a2942606f31007545673ae12c0650b60"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2026:GLOCE3H2COBIUK3L7FMEDTKC24","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Simulating is not always understanding: When model complexity obscures biology","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["physics.bio-ph"],"primary_cat":"q-bio.MN","authors_text":"Alejandro F\\'abregas-Tejeda, Bart Smeets, Grant Ramsey, Lendert Gelens, Sylvia Wenmackers","submitted_at":"2026-08-07T09:17:13Z","abstract_excerpt":"In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a complete cell cycle. While these models span a continuum of detail, increasing complexity changes what they capture and are able to explain, what they can predict, and how they can fall short. A model contributes to understanding only when it makes novel predictions, reveals an unexpected coupling between processes, or fails in a way that identifies missing parameters. We contend that what is impor"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.06998","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2608.06998/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-08-10T01:12:48Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"J+ZmUvybHmEDJuaiVlsklOKVK/V/5ohNtrTywEoIsf2NcwRvUOTrumCkcYcrfIikUqvAKuMwbBBVEM7kYo4WAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-22T01:10:30.389199Z"},"content_sha256":"dcc1524e5eb7eb21b5eb70060a0f3a9b4f725ceadc6b3222d025b004202452f7","schema_version":"1.0","event_id":"sha256:dcc1524e5eb7eb21b5eb70060a0f3a9b4f725ceadc6b3222d025b004202452f7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GLOCE3H2COBIUK3L7FMEDTKC24/bundle.json","state_url":"https://pith.science/pith/GLOCE3H2COBIUK3L7FMEDTKC24/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GLOCE3H2COBIUK3L7FMEDTKC24/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-22T01:10:30Z","links":{"resolver":"https://pith.science/pith/GLOCE3H2COBIUK3L7FMEDTKC24","bundle":"https://pith.science/pith/GLOCE3H2COBIUK3L7FMEDTKC24/bundle.json","state":"https://pith.science/pith/GLOCE3H2COBIUK3L7FMEDTKC24/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GLOCE3H2COBIUK3L7FMEDTKC24/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:GLOCE3H2COBIUK3L7FMEDTKC24","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d0886ac0db239a3c704d4a0021fdb8c74b7d779391a72d1444535544e4e7a911","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-08-07T09:17:13Z","title_canon_sha256":"549a4fdb95dd467b716244cfca76caf95b70e57f01146d973759dbe6b96ec2c1"},"schema_version":"1.0","source":{"id":"2608.06998","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2608.06998","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"arxiv_version","alias_value":"2608.06998v1","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2608.06998","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_12","alias_value":"GLOCE3H2COBI","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_16","alias_value":"GLOCE3H2COBIUK3L","created_at":"2026-08-10T01:12:48Z"},{"alias_kind":"pith_short_8","alias_value":"GLOCE3H2","created_at":"2026-08-10T01:12:48Z"}],"graph_snapshots":[{"event_id":"sha256:dcc1524e5eb7eb21b5eb70060a0f3a9b4f725ceadc6b3222d025b004202452f7","target":"graph","created_at":"2026-08-10T01:12:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2608.06998/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"In cell biology, computational models of biological systems range from minimal representations with a handful of parameters to whole-cell simulations tracking thousands of molecular species across a complete cell cycle. While these models span a continuum of detail, increasing complexity changes what they capture and are able to explain, what they can predict, and how they can fall short. A model contributes to understanding only when it makes novel predictions, reveals an unexpected coupling between processes, or fails in a way that identifies missing parameters. We contend that what is impor","authors_text":"Alejandro F\\'abregas-Tejeda, Bart Smeets, Grant Ramsey, Lendert Gelens, Sylvia Wenmackers","cross_cats":["physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-08-07T09:17:13Z","title":"Simulating is not always understanding: When model complexity obscures biology"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2608.06998","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9b25d3a4d959495247911b9247f5d862a2942606f31007545673ae12c0650b60","target":"record","created_at":"2026-08-10T01:12:48Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d0886ac0db239a3c704d4a0021fdb8c74b7d779391a72d1444535544e4e7a911","cross_cats_sorted":["physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.MN","submitted_at":"2026-08-07T09:17:13Z","title_canon_sha256":"549a4fdb95dd467b716244cfca76caf95b70e57f01146d973759dbe6b96ec2c1"},"schema_version":"1.0","source":{"id":"2608.06998","kind":"arxiv","version":1}},"canonical_sha256":"32dc226cfa13828a2b6bf95841cd42d732239f6424ca1e48eb1041cdb67007de","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"32dc226cfa13828a2b6bf95841cd42d732239f6424ca1e48eb1041cdb67007de","first_computed_at":"2026-08-10T01:12:48.092839Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-08-10T01:12:48.092839Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"ZUvMT4oMJ5PKl3kdMHED2RtQ2VYQl/bGbpBp6zLDiUhemiUpqSIPpPCYV1e80W+IV0ZDDQwXX26s7fVIjOspBw==","signature_status":"signed_v1","signed_at":"2026-08-10T01:12:48.095489Z","signed_message":"canonical_sha256_bytes"},"source_id":"2608.06998","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9b25d3a4d959495247911b9247f5d862a2942606f31007545673ae12c0650b60","sha256:dcc1524e5eb7eb21b5eb70060a0f3a9b4f725ceadc6b3222d025b004202452f7"],"state_sha256":"0c322d86238d8779dd2ffd3efcbfe5a70c2e8ada8af95143e132de4d8feb1dfe"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nBDl3oE4HVB17P3u4RBUUSq/69ExMus6DbWmCo/FKa5EC3EBm461WMW2NXNapMwfCV4nJDfkolCY2UlIQR8ICg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-22T01:10:30.393927Z","bundle_sha256":"d0dcb19397bd07707cc6184c36dadea0871eaf54cdaddb8e49cbce69398e6745"}}