{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:GM7L3MVWWGCR7SY4CH3L3DNYBC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"50674220ed2a1dfbec4a7cbba553f89a91dfd21f04e76a3d6494a5388ee01bfb","cross_cats_sorted":["q-bio.GN"],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2023-07-17T19:34:59Z","title_canon_sha256":"cbe430f686dd00336135e31ae28157ca9e3cee2fe19a864a903d6da3eb4c59ce"},"schema_version":"1.0","source":{"id":"2307.08801","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2307.08801","created_at":"2026-07-05T06:31:34Z"},{"alias_kind":"arxiv_version","alias_value":"2307.08801v1","created_at":"2026-07-05T06:31:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2307.08801","created_at":"2026-07-05T06:31:34Z"},{"alias_kind":"pith_short_12","alias_value":"GM7L3MVWWGCR","created_at":"2026-07-05T06:31:34Z"},{"alias_kind":"pith_short_16","alias_value":"GM7L3MVWWGCR7SY4","created_at":"2026-07-05T06:31:34Z"},{"alias_kind":"pith_short_8","alias_value":"GM7L3MVW","created_at":"2026-07-05T06:31:34Z"}],"graph_snapshots":[{"event_id":"sha256:a993b460bee2649fa74a8fed09349ce1908bbb7400a40a533dd58cdabbfb1608","target":"graph","created_at":"2026-07-05T06:31:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2307.08801/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Experimental screening and selection pipelines for the discovery of novel riboswitches are expensive, time-consuming, and inefficient. Using computational methods to reduce the number of candidates for the screen could drastically decrease these costs. However, existing computational approaches do not fully satisfy all requirements for the design of such initial screening libraries. In this work, we present a new method, libLEARNA, capable of providing RNA focus libraries of diverse variable-length qualified candidates. Our novel structure-based design approach considers global properties as w","authors_text":"Frank Hutter, Frederic Runge, J\\\"org K. H. Franke","cross_cats":["q-bio.GN"],"headline":"","license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2023-07-17T19:34:59Z","title":"Towards Automated Design of Riboswitches"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2307.08801","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c49cc62ad500121ecef15982ecff4e5203123ac580f6489cfea2b7f56ea09f9c","target":"record","created_at":"2026-07-05T06:31:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"50674220ed2a1dfbec4a7cbba553f89a91dfd21f04e76a3d6494a5388ee01bfb","cross_cats_sorted":["q-bio.GN"],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"cs.LG","submitted_at":"2023-07-17T19:34:59Z","title_canon_sha256":"cbe430f686dd00336135e31ae28157ca9e3cee2fe19a864a903d6da3eb4c59ce"},"schema_version":"1.0","source":{"id":"2307.08801","kind":"arxiv","version":1}},"canonical_sha256":"333ebdb2b6b1851fcb1c11f6bd8db8088e1d5f2fb69026a8d3d5a173f23e5ae9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"333ebdb2b6b1851fcb1c11f6bd8db8088e1d5f2fb69026a8d3d5a173f23e5ae9","first_computed_at":"2026-07-05T06:31:34.642136Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T06:31:34.642136Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"DLdBuV4ziM8xG5artARe5jyEbqrMR09bnmsPbOUX8AJaLSR8LaeuIvhZB2mm8sgVTlwy1rEV/iGW9xzPbCRYCQ==","signature_status":"signed_v1","signed_at":"2026-07-05T06:31:34.642625Z","signed_message":"canonical_sha256_bytes"},"source_id":"2307.08801","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c49cc62ad500121ecef15982ecff4e5203123ac580f6489cfea2b7f56ea09f9c","sha256:a993b460bee2649fa74a8fed09349ce1908bbb7400a40a533dd58cdabbfb1608"],"state_sha256":"8ca7091bf5cb603635109b3fd04d578618eb75340778325387f81f5fe2da33a4"}