{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:GMYEG26KBF6LPC4SS4YJKUZ6IK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"9cb49fd2525c3c07ff617d6414b194afe2a03e37ee5ebe432b2f7eff4bb86140","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-13T14:38:53Z","title_canon_sha256":"8cde8844f9e354409ca1915a6cdc3eb6fc8b0d6ab8baec2bcde9eaa6885033f0"},"schema_version":"1.0","source":{"id":"2502.09372","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.09372","created_at":"2026-07-05T11:22:36Z"},{"alias_kind":"arxiv_version","alias_value":"2502.09372v2","created_at":"2026-07-05T11:22:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.09372","created_at":"2026-07-05T11:22:36Z"},{"alias_kind":"pith_short_12","alias_value":"GMYEG26KBF6L","created_at":"2026-07-05T11:22:36Z"},{"alias_kind":"pith_short_16","alias_value":"GMYEG26KBF6LPC4S","created_at":"2026-07-05T11:22:36Z"},{"alias_kind":"pith_short_8","alias_value":"GMYEG26K","created_at":"2026-07-05T11:22:36Z"}],"graph_snapshots":[{"event_id":"sha256:bb6e43f000b8beb3653e641ee76c605a2cee76469a17baa1a70119e4ab207a6f","target":"graph","created_at":"2026-07-05T11:22:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.09372/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Proteins exist as a dynamic ensemble of multiple conformations, and these motions are often crucial for their functions. However, current structure prediction methods predominantly yield a single conformation, overlooking the conformational heterogeneity revealed by diverse experimental modalities. Here, we present a framework for building experiment-grounded protein structure generative models that infer conformational ensembles consistent with measured experimental data. The key idea is to treat state-of-the-art protein structure predictors (e.g., AlphaFold3) as sequence-conditioned structur","authors_text":"Advaith Maddipatla, Ailie Marx, Alex M. Bronstein, Meital Bojan, Nadav Bojan Sellam, Paul Schanda, Sanketh Vedula","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-13T14:38:53Z","title":"Inverse problems with experiment-guided AlphaFold"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.09372","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:002959c9e20bc12ba688db7f030daa2832c32a5c75de3eab5ad3d1e619b2427b","target":"record","created_at":"2026-07-05T11:22:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"9cb49fd2525c3c07ff617d6414b194afe2a03e37ee5ebe432b2f7eff4bb86140","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2025-02-13T14:38:53Z","title_canon_sha256":"8cde8844f9e354409ca1915a6cdc3eb6fc8b0d6ab8baec2bcde9eaa6885033f0"},"schema_version":"1.0","source":{"id":"2502.09372","kind":"arxiv","version":2}},"canonical_sha256":"3330436bca097cb78b92973095533e4293787d8cbf3e414500ddc4e337ab2016","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3330436bca097cb78b92973095533e4293787d8cbf3e414500ddc4e337ab2016","first_computed_at":"2026-07-05T11:22:36.668438Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:22:36.668438Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Ja/DrXgZgze1Nkgy31mNUD322j1Rm74mDxs/RMa7bZPWFTJAGjri6FGUfa8RvDpVnwKej/li4FGIpTRgOZO/CQ==","signature_status":"signed_v1","signed_at":"2026-07-05T11:22:36.668987Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.09372","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:002959c9e20bc12ba688db7f030daa2832c32a5c75de3eab5ad3d1e619b2427b","sha256:bb6e43f000b8beb3653e641ee76c605a2cee76469a17baa1a70119e4ab207a6f"],"state_sha256":"b72a2034fa321ec803b7507c9a537ef61347f78152bf090be2267e8b9e78a834"}