{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:GNSSKLQMMYUCISCF2BGDXGIVJG","short_pith_number":"pith:GNSSKLQM","canonical_record":{"source":{"id":"1308.2380","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-08-11T11:15:47Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"26339ba7fb23b060e82e9bf9f7d654aaeea256e71c8600b9b78c6ced6ab9b642","abstract_canon_sha256":"1185d065718f9cecc93b42dcdebab222ab5f70cec3629a555ce8fb6ebd74eb0d"},"schema_version":"1.0"},"canonical_sha256":"3365252e0c6628244845d04c3b9915498bc51d0ba49a4aba4a28e06f32c66092","source":{"kind":"arxiv","id":"1308.2380","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1308.2380","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"arxiv_version","alias_value":"1308.2380v1","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1308.2380","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"pith_short_12","alias_value":"GNSSKLQMMYUC","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_16","alias_value":"GNSSKLQMMYUCISCF","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_8","alias_value":"GNSSKLQM","created_at":"2026-05-18T12:27:45Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:GNSSKLQMMYUCISCF2BGDXGIVJG","target":"record","payload":{"canonical_record":{"source":{"id":"1308.2380","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-08-11T11:15:47Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"26339ba7fb23b060e82e9bf9f7d654aaeea256e71c8600b9b78c6ced6ab9b642","abstract_canon_sha256":"1185d065718f9cecc93b42dcdebab222ab5f70cec3629a555ce8fb6ebd74eb0d"},"schema_version":"1.0"},"canonical_sha256":"3365252e0c6628244845d04c3b9915498bc51d0ba49a4aba4a28e06f32c66092","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:16:07.594235Z","signature_b64":"7khslYI6uR8xdeSQE/G09FbkIEAJ9veSOt9SH0qNQzfT4PncSAo5d/armx9a9YYpeQv2GCbIqoCC7BYYng9WAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3365252e0c6628244845d04c3b9915498bc51d0ba49a4aba4a28e06f32c66092","last_reissued_at":"2026-05-18T03:16:07.593434Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:16:07.593434Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1308.2380","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:16:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"H2LYI4l4bFtClYf3iOCXQ90Vcei9jNB0kXGJw4SH9amXkEkAJSbLjkkWaYqWoUaLBNGuYk1D9lLwXuzEoehfAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T11:31:52.780969Z"},"content_sha256":"57a6b88b9dd859a949eae6e483dd460feec9671df1dfa115d0c724ffb5c252e8","schema_version":"1.0","event_id":"sha256:57a6b88b9dd859a949eae6e483dd460feec9671df1dfa115d0c724ffb5c252e8"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:GNSSKLQMMYUCISCF2BGDXGIVJG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Numerical Simulation of Folding and Unfolding of Proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Maksim Kouza","submitted_at":"2013-08-11T11:15:47Z","abstract_excerpt":"The thesis examines in detail the folding and unfolding processes of a number of proteins including hbSBD, DDLNF4, single and multi Ubiquitin. Using simplified coarse-grained off-lattice Go model and CD experiments we have shown the two-state behavior of hbSBD protein. It was shown that refolding pathways of single Ubiquitin depend on what end is anchored to the surface. Namely, the fixation of the N-terminal changes refolding pathways but anchoring the C-terminal leaves them unchanged. Interestingly, the end fixation has no effect on multi-domain Ubiquitin. Using the Go modeling and all-atom "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1308.2380","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:16:07Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pgRUuvweWHHD3xhdas+o2u23dBYTScNRPBqRgz1mmUIg29N1bZuBNxi/ca82t7imnNG9Ec9YOeS+NLuvKPbGDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-26T11:31:52.781304Z"},"content_sha256":"df6f5f5508b7b3b011eb7de123eb3ac91c93a8575506bcd1afd2c8711c89f3e4","schema_version":"1.0","event_id":"sha256:df6f5f5508b7b3b011eb7de123eb3ac91c93a8575506bcd1afd2c8711c89f3e4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/bundle.json","state_url":"https://pith.science/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-26T11:31:52Z","links":{"resolver":"https://pith.science/pith/GNSSKLQMMYUCISCF2BGDXGIVJG","bundle":"https://pith.science/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/bundle.json","state":"https://pith.science/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GNSSKLQMMYUCISCF2BGDXGIVJG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:GNSSKLQMMYUCISCF2BGDXGIVJG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1185d065718f9cecc93b42dcdebab222ab5f70cec3629a555ce8fb6ebd74eb0d","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-08-11T11:15:47Z","title_canon_sha256":"26339ba7fb23b060e82e9bf9f7d654aaeea256e71c8600b9b78c6ced6ab9b642"},"schema_version":"1.0","source":{"id":"1308.2380","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1308.2380","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"arxiv_version","alias_value":"1308.2380v1","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1308.2380","created_at":"2026-05-18T03:16:07Z"},{"alias_kind":"pith_short_12","alias_value":"GNSSKLQMMYUC","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_16","alias_value":"GNSSKLQMMYUCISCF","created_at":"2026-05-18T12:27:45Z"},{"alias_kind":"pith_short_8","alias_value":"GNSSKLQM","created_at":"2026-05-18T12:27:45Z"}],"graph_snapshots":[{"event_id":"sha256:df6f5f5508b7b3b011eb7de123eb3ac91c93a8575506bcd1afd2c8711c89f3e4","target":"graph","created_at":"2026-05-18T03:16:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The thesis examines in detail the folding and unfolding processes of a number of proteins including hbSBD, DDLNF4, single and multi Ubiquitin. Using simplified coarse-grained off-lattice Go model and CD experiments we have shown the two-state behavior of hbSBD protein. It was shown that refolding pathways of single Ubiquitin depend on what end is anchored to the surface. Namely, the fixation of the N-terminal changes refolding pathways but anchoring the C-terminal leaves them unchanged. Interestingly, the end fixation has no effect on multi-domain Ubiquitin. Using the Go modeling and all-atom ","authors_text":"Maksim Kouza","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-08-11T11:15:47Z","title":"Numerical Simulation of Folding and Unfolding of Proteins"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1308.2380","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:57a6b88b9dd859a949eae6e483dd460feec9671df1dfa115d0c724ffb5c252e8","target":"record","created_at":"2026-05-18T03:16:07Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1185d065718f9cecc93b42dcdebab222ab5f70cec3629a555ce8fb6ebd74eb0d","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2013-08-11T11:15:47Z","title_canon_sha256":"26339ba7fb23b060e82e9bf9f7d654aaeea256e71c8600b9b78c6ced6ab9b642"},"schema_version":"1.0","source":{"id":"1308.2380","kind":"arxiv","version":1}},"canonical_sha256":"3365252e0c6628244845d04c3b9915498bc51d0ba49a4aba4a28e06f32c66092","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3365252e0c6628244845d04c3b9915498bc51d0ba49a4aba4a28e06f32c66092","first_computed_at":"2026-05-18T03:16:07.593434Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:16:07.593434Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"7khslYI6uR8xdeSQE/G09FbkIEAJ9veSOt9SH0qNQzfT4PncSAo5d/armx9a9YYpeQv2GCbIqoCC7BYYng9WAw==","signature_status":"signed_v1","signed_at":"2026-05-18T03:16:07.594235Z","signed_message":"canonical_sha256_bytes"},"source_id":"1308.2380","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:57a6b88b9dd859a949eae6e483dd460feec9671df1dfa115d0c724ffb5c252e8","sha256:df6f5f5508b7b3b011eb7de123eb3ac91c93a8575506bcd1afd2c8711c89f3e4"],"state_sha256":"6ec209ad5eb383ada8b11b25e03cc5302d4fd944aa0bf3c86fb2538c42fb0d8c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"G3sZz+z3St27HP1GqMoWc+5dVm9acI8u6VO/mBtAskAi+vfDnLV+eD3gYS8jDeQjzGXz3N6quPw+Yjv+xUXkBw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-26T11:31:52.783128Z","bundle_sha256":"203cfb9b52e22b616f67428e6662bf036cac9abbc325e7afcb2f2924a4fe57e2"}}