{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:GPLLBO6574KYQ7FDZZMI3STJFI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e4b99053f0ba25850fd22ff5263e96c42eb67422ffeb85f23a1729696db1508b","cross_cats_sorted":["q-bio.QM","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2015-03-03T20:00:31Z","title_canon_sha256":"a33c87b4b64f93e1a10149d5009c5ac8d4bb23e708a42c4c552cb68154875e01"},"schema_version":"1.0","source":{"id":"1503.01081","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1503.01081","created_at":"2026-05-18T01:29:38Z"},{"alias_kind":"arxiv_version","alias_value":"1503.01081v2","created_at":"2026-05-18T01:29:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.01081","created_at":"2026-05-18T01:29:38Z"},{"alias_kind":"pith_short_12","alias_value":"GPLLBO6574KY","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"GPLLBO6574KYQ7FD","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"GPLLBO65","created_at":"2026-05-18T12:29:22Z"}],"graph_snapshots":[{"event_id":"sha256:ddf9961f1fcabd45844bd6a784baef2858540186230aff54da1889c331ce64af","target":"graph","created_at":"2026-05-18T01:29:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Genes with similar transcriptional activation kinetics can display very different temporal mRNA profiles due to differences in transcription time, degradation rate and RNA processing kinetics. Recent studies have shown that a splicing-associated RNA production delay can be significant. We introduce a joint model of transcriptional activation and mRNA accumulation which can be used for inference of transcription rate, RNA production delay and degradation rate given genome-wide data from high-throughput sequencing time course experiments. We combine a mechanistic differential equation model with","authors_text":"Antti Honkela, Filomena Matarese, George Reid, Hande Topa, Hendrik G. Stunnenberg, Iryna Charapitsa, Jaakko Peltonen, Korbinian Grote, Magnus Rattray, Neil D. Lawrence","cross_cats":["q-bio.QM","stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2015-03-03T20:00:31Z","title":"Genome-wide modelling of transcription kinetics reveals patterns of RNA production delays"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.01081","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f42ca32304e5bce5a88a62d4609031451c1640911240d983b6e957e191f8c76e","target":"record","created_at":"2026-05-18T01:29:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e4b99053f0ba25850fd22ff5263e96c42eb67422ffeb85f23a1729696db1508b","cross_cats_sorted":["q-bio.QM","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.GN","submitted_at":"2015-03-03T20:00:31Z","title_canon_sha256":"a33c87b4b64f93e1a10149d5009c5ac8d4bb23e708a42c4c552cb68154875e01"},"schema_version":"1.0","source":{"id":"1503.01081","kind":"arxiv","version":2}},"canonical_sha256":"33d6b0bbddff15887ca3ce588dca692a0efde55f664b6fee6268387ab3681730","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"33d6b0bbddff15887ca3ce588dca692a0efde55f664b6fee6268387ab3681730","first_computed_at":"2026-05-18T01:29:38.358970Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:29:38.358970Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"DOkFmznJ87+kCOyLKN89WOMOwHfbOcc+aXJffqIEo8IBfkelNnV84O4OWmZDA8CnIef0kCKge+VNfaYPfu7NBA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:29:38.359521Z","signed_message":"canonical_sha256_bytes"},"source_id":"1503.01081","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f42ca32304e5bce5a88a62d4609031451c1640911240d983b6e957e191f8c76e","sha256:ddf9961f1fcabd45844bd6a784baef2858540186230aff54da1889c331ce64af"],"state_sha256":"afaec768e3257ff6c319220985f6075bb2940ff9c6057eec15edc54b562e92b0"}