{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:GRXRFLVOJXW4MJEBTSV6W77LLB","short_pith_number":"pith:GRXRFLVO","canonical_record":{"source":{"id":"1009.4474","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-09-22T20:43:17Z","cross_cats_sorted":["q-bio.GN","q-bio.PE","q-bio.SC"],"title_canon_sha256":"70ef961efc7a83d5f9f41e2cb8fbef45a74d045845db3ed101b3c93d73a2df1a","abstract_canon_sha256":"69bba5d2628f5eaeedad2f40201fb305f586799c290223505fb5e01f15489a7e"},"schema_version":"1.0"},"canonical_sha256":"346f12aeae4dedc624819cabeb7feb584eb39995bc15e4a7423d9e5189732988","source":{"kind":"arxiv","id":"1009.4474","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1009.4474","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"arxiv_version","alias_value":"1009.4474v1","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1009.4474","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"pith_short_12","alias_value":"GRXRFLVOJXW4","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"GRXRFLVOJXW4MJEB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"GRXRFLVO","created_at":"2026-05-18T12:26:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:GRXRFLVOJXW4MJEBTSV6W77LLB","target":"record","payload":{"canonical_record":{"source":{"id":"1009.4474","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-09-22T20:43:17Z","cross_cats_sorted":["q-bio.GN","q-bio.PE","q-bio.SC"],"title_canon_sha256":"70ef961efc7a83d5f9f41e2cb8fbef45a74d045845db3ed101b3c93d73a2df1a","abstract_canon_sha256":"69bba5d2628f5eaeedad2f40201fb305f586799c290223505fb5e01f15489a7e"},"schema_version":"1.0"},"canonical_sha256":"346f12aeae4dedc624819cabeb7feb584eb39995bc15e4a7423d9e5189732988","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:40:30.405568Z","signature_b64":"38ZTC2ExK4C+32mMjKSwmZAeC86SPzzlEUPlAE9K1s+1XfCgHSEGhOhslkLJhewkmGTySluJ7uYuK+T5DvtHDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"346f12aeae4dedc624819cabeb7feb584eb39995bc15e4a7423d9e5189732988","last_reissued_at":"2026-05-18T04:40:30.404798Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:40:30.404798Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1009.4474","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:40:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XEcewTJywgdfKSIqWdOC95m90++maX3UIzAJj9X7D/8hYQ06cUYwHQOJKurJsEDrifcR1IjY/lSJPdTGAUeLCg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T22:33:15.969813Z"},"content_sha256":"fdc448a3b83100df6018fb50fd64228c85e57631212239cd0be6f6d1ccda8eb2","schema_version":"1.0","event_id":"sha256:fdc448a3b83100df6018fb50fd64228c85e57631212239cd0be6f6d1ccda8eb2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:GRXRFLVOJXW4MJEBTSV6W77LLB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Toolbox model of evolution of prokaryotic metabolic networks and their regulation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.GN","q-bio.PE","q-bio.SC"],"primary_cat":"q-bio.MN","authors_text":"Kim Sneppen, Sandeep Krishna, Sergei Maslov, Tin Yau Pang","submitted_at":"2010-09-22T20:43:17Z","abstract_excerpt":"It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes. We propose a conceptual explanation of this finding and illustrate it using a simple model in which metabolic and regulatory networks of prokaryotes are shaped by horizontal gene transfer of coregulated metabolic pathways. Adapting to a new environmental condition monitored by a new transcription factor (e.g., learning to use another nutrient) involves both acquiring new enzymes and reusing some of the enzymes already encoded in the g"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1009.4474","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:40:30Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CCXizDbDU8hAnuO1xLCKYZkgy4Vw0tMt5/7CnKoJr+d4CCvp5AmXf6ZC+K+d0zYefEvT+VOVAaH9QcHRr/wfAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T22:33:15.970493Z"},"content_sha256":"3bb60626570aa1659a128fea501dbb8da57a2ca3c3b0972819ce8683bb1b9b1d","schema_version":"1.0","event_id":"sha256:3bb60626570aa1659a128fea501dbb8da57a2ca3c3b0972819ce8683bb1b9b1d"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/bundle.json","state_url":"https://pith.science/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-20T22:33:15Z","links":{"resolver":"https://pith.science/pith/GRXRFLVOJXW4MJEBTSV6W77LLB","bundle":"https://pith.science/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/bundle.json","state":"https://pith.science/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GRXRFLVOJXW4MJEBTSV6W77LLB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:GRXRFLVOJXW4MJEBTSV6W77LLB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"69bba5d2628f5eaeedad2f40201fb305f586799c290223505fb5e01f15489a7e","cross_cats_sorted":["q-bio.GN","q-bio.PE","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-09-22T20:43:17Z","title_canon_sha256":"70ef961efc7a83d5f9f41e2cb8fbef45a74d045845db3ed101b3c93d73a2df1a"},"schema_version":"1.0","source":{"id":"1009.4474","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1009.4474","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"arxiv_version","alias_value":"1009.4474v1","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1009.4474","created_at":"2026-05-18T04:40:30Z"},{"alias_kind":"pith_short_12","alias_value":"GRXRFLVOJXW4","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"GRXRFLVOJXW4MJEB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"GRXRFLVO","created_at":"2026-05-18T12:26:07Z"}],"graph_snapshots":[{"event_id":"sha256:3bb60626570aa1659a128fea501dbb8da57a2ca3c3b0972819ce8683bb1b9b1d","target":"graph","created_at":"2026-05-18T04:40:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"It has been reported that the number of transcription factors encoded in prokaryotic genomes scales approximately quadratically with their total number of genes. We propose a conceptual explanation of this finding and illustrate it using a simple model in which metabolic and regulatory networks of prokaryotes are shaped by horizontal gene transfer of coregulated metabolic pathways. Adapting to a new environmental condition monitored by a new transcription factor (e.g., learning to use another nutrient) involves both acquiring new enzymes and reusing some of the enzymes already encoded in the g","authors_text":"Kim Sneppen, Sandeep Krishna, Sergei Maslov, Tin Yau Pang","cross_cats":["q-bio.GN","q-bio.PE","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-09-22T20:43:17Z","title":"Toolbox model of evolution of prokaryotic metabolic networks and their regulation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1009.4474","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:fdc448a3b83100df6018fb50fd64228c85e57631212239cd0be6f6d1ccda8eb2","target":"record","created_at":"2026-05-18T04:40:30Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"69bba5d2628f5eaeedad2f40201fb305f586799c290223505fb5e01f15489a7e","cross_cats_sorted":["q-bio.GN","q-bio.PE","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2010-09-22T20:43:17Z","title_canon_sha256":"70ef961efc7a83d5f9f41e2cb8fbef45a74d045845db3ed101b3c93d73a2df1a"},"schema_version":"1.0","source":{"id":"1009.4474","kind":"arxiv","version":1}},"canonical_sha256":"346f12aeae4dedc624819cabeb7feb584eb39995bc15e4a7423d9e5189732988","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"346f12aeae4dedc624819cabeb7feb584eb39995bc15e4a7423d9e5189732988","first_computed_at":"2026-05-18T04:40:30.404798Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:40:30.404798Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"38ZTC2ExK4C+32mMjKSwmZAeC86SPzzlEUPlAE9K1s+1XfCgHSEGhOhslkLJhewkmGTySluJ7uYuK+T5DvtHDA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:40:30.405568Z","signed_message":"canonical_sha256_bytes"},"source_id":"1009.4474","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:fdc448a3b83100df6018fb50fd64228c85e57631212239cd0be6f6d1ccda8eb2","sha256:3bb60626570aa1659a128fea501dbb8da57a2ca3c3b0972819ce8683bb1b9b1d"],"state_sha256":"ad01d32dfb153cc74bdca08488305d4e31f78750a44f44e157489989c319a43b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oEW7QXrcZ7lK8zBCASPDC9eW89jRnjuk1HBSt2j5V3FTg71FVVVAiwHIW4e6e413b9fNpeNY8P7Bf/Yd1YikBg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-20T22:33:15.974007Z","bundle_sha256":"4a89767eeca0634c2009d795250310c3e7c66df81c97263410b54f54f26d3740"}}