{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:GXEFTZMNR4MQ6P363HVNW4AT7J","short_pith_number":"pith:GXEFTZMN","schema_version":"1.0","canonical_sha256":"35c859e58d8f190f3f7ed9eadb7013fa4b7e158d29c11a732304ec80420ee847","source":{"kind":"arxiv","id":"1503.02704","version":1},"attestation_state":"computed","paper":{"title":"Protein Adsorption into Mesopores: A Combination of Electrostatic Interaction, Counterion Release and van der Waals Forces","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.mes-hall","cond-mat.mtrl-sci","cond-mat.soft","physics.chem-ph"],"primary_cat":"physics.bio-ph","authors_text":"Patrick Huber, Sebastian T. Moerz","submitted_at":"2015-03-09T21:28:07Z","abstract_excerpt":"Bovine heart cytochrome c has been immobilized into the mesoporous silica host material SBA-15 in both its native folded and urea-unfolded state. The comparison of the two folding states' behavior casts doubt on the commonly used explanation of cytochrome c adsorption, i.e. the electrostatic interaction model. A detailed investigation of the protein binding as a function of pH and ionic strength of the buffer solution reveals the complex nature of the protein-silica interaction. Electrostatic interaction, van der Waals forces and entropic contributions by counterion release each contribute to "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1503.02704","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-03-09T21:28:07Z","cross_cats_sorted":["cond-mat.mes-hall","cond-mat.mtrl-sci","cond-mat.soft","physics.chem-ph"],"title_canon_sha256":"7f8106520eb1f002c63cd0d6fdffcb54b2a66755dd5b6cec8e0b2a818a53af29","abstract_canon_sha256":"c1350781f8f20be2d8e8f0cc2fb092e6fdb208ea370e5cbce2fe494db0193835"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:25:17.993186Z","signature_b64":"3U7PNMieJb9LvqqrOlrkkjOJMgA5cKcDt6HcEuySSnqQZl/H18U9r7p3M21ZwhyRfW7baF9ap9mgwAHa+Xg6DA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"35c859e58d8f190f3f7ed9eadb7013fa4b7e158d29c11a732304ec80420ee847","last_reissued_at":"2026-05-18T02:25:17.992830Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:25:17.992830Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Protein Adsorption into Mesopores: A Combination of Electrostatic Interaction, Counterion Release and van der Waals Forces","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.mes-hall","cond-mat.mtrl-sci","cond-mat.soft","physics.chem-ph"],"primary_cat":"physics.bio-ph","authors_text":"Patrick Huber, Sebastian T. Moerz","submitted_at":"2015-03-09T21:28:07Z","abstract_excerpt":"Bovine heart cytochrome c has been immobilized into the mesoporous silica host material SBA-15 in both its native folded and urea-unfolded state. The comparison of the two folding states' behavior casts doubt on the commonly used explanation of cytochrome c adsorption, i.e. the electrostatic interaction model. A detailed investigation of the protein binding as a function of pH and ionic strength of the buffer solution reveals the complex nature of the protein-silica interaction. Electrostatic interaction, van der Waals forces and entropic contributions by counterion release each contribute to "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1503.02704","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1503.02704","created_at":"2026-05-18T02:25:17.992886+00:00"},{"alias_kind":"arxiv_version","alias_value":"1503.02704v1","created_at":"2026-05-18T02:25:17.992886+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1503.02704","created_at":"2026-05-18T02:25:17.992886+00:00"},{"alias_kind":"pith_short_12","alias_value":"GXEFTZMNR4MQ","created_at":"2026-05-18T12:29:22.688609+00:00"},{"alias_kind":"pith_short_16","alias_value":"GXEFTZMNR4MQ6P36","created_at":"2026-05-18T12:29:22.688609+00:00"},{"alias_kind":"pith_short_8","alias_value":"GXEFTZMN","created_at":"2026-05-18T12:29:22.688609+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J","json":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J.json","graph_json":"https://pith.science/api/pith-number/GXEFTZMNR4MQ6P363HVNW4AT7J/graph.json","events_json":"https://pith.science/api/pith-number/GXEFTZMNR4MQ6P363HVNW4AT7J/events.json","paper":"https://pith.science/paper/GXEFTZMN"},"agent_actions":{"view_html":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J","download_json":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J.json","view_paper":"https://pith.science/paper/GXEFTZMN","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1503.02704&json=true","fetch_graph":"https://pith.science/api/pith-number/GXEFTZMNR4MQ6P363HVNW4AT7J/graph.json","fetch_events":"https://pith.science/api/pith-number/GXEFTZMNR4MQ6P363HVNW4AT7J/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J/action/timestamp_anchor","attest_storage":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J/action/storage_attestation","attest_author":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J/action/author_attestation","sign_citation":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J/action/citation_signature","submit_replication":"https://pith.science/pith/GXEFTZMNR4MQ6P363HVNW4AT7J/action/replication_record"}},"created_at":"2026-05-18T02:25:17.992886+00:00","updated_at":"2026-05-18T02:25:17.992886+00:00"}