{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:GZTAUE76DJOE3C2TLSMZH5EZKO","short_pith_number":"pith:GZTAUE76","canonical_record":{"source":{"id":"2506.03086","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T17:10:49Z","cross_cats_sorted":[],"title_canon_sha256":"51b14680759c327dbdfe2c96a063dd67dbd60ae625074c0929889014faf9bf11","abstract_canon_sha256":"d4f8d39d56f22881e26c44b4254f6f9f6e865d3946b67c6af90d503948f8d12b"},"schema_version":"1.0"},"canonical_sha256":"36660a13fe1a5c4d8b535c9993f49953b222ddbc85988cbee0c0de95f466b379","source":{"kind":"arxiv","id":"2506.03086","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03086","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03086v1","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03086","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_12","alias_value":"GZTAUE76DJOE","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_16","alias_value":"GZTAUE76DJOE3C2T","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_8","alias_value":"GZTAUE76","created_at":"2026-07-05T11:15:14Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:GZTAUE76DJOE3C2TLSMZH5EZKO","target":"record","payload":{"canonical_record":{"source":{"id":"2506.03086","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T17:10:49Z","cross_cats_sorted":[],"title_canon_sha256":"51b14680759c327dbdfe2c96a063dd67dbd60ae625074c0929889014faf9bf11","abstract_canon_sha256":"d4f8d39d56f22881e26c44b4254f6f9f6e865d3946b67c6af90d503948f8d12b"},"schema_version":"1.0"},"canonical_sha256":"36660a13fe1a5c4d8b535c9993f49953b222ddbc85988cbee0c0de95f466b379","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:15:14.614463Z","signature_b64":"LRPrFmtrM0rbvddQJZ4UBNz/VNsIEmzP6e0+GL+tPu3de7MvKqShip3EofLKkI0zmvM+sAIwycCEFxgG6ZBdAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"36660a13fe1a5c4d8b535c9993f49953b222ddbc85988cbee0c0de95f466b379","last_reissued_at":"2026-07-05T11:15:14.613974Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:15:14.613974Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2506.03086","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4VK7vQKW+Mri691UAVLnhyHy9Zgl2lBKsRUbInliuNcIF1ClJZbV1m26fGFbQ+SZzrvD6sB9HFr4Ywwx/4qgDA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T03:27:13.951375Z"},"content_sha256":"2f716306dc38ac92c36cef46f99eef875fc34f2869d38bf57cb6185fd40891cf","schema_version":"1.0","event_id":"sha256:2f716306dc38ac92c36cef46f99eef875fc34f2869d38bf57cb6185fd40891cf"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:GZTAUE76DJOE3C2TLSMZH5EZKO","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Synergy-Informed Design of Platform Trials for Combination Therapies","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"stat.ME","authors_text":"Lin Wang, Man Mandy Jin, Nan Miles Xi, Xin Huang","submitted_at":"2025-06-03T17:10:49Z","abstract_excerpt":"Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, designing clinical trials for these regimens poses unique statistical challenges due to multiple hypothesis testing, shared control groups, and overlapping treatment components that induce complex correlation structures. In this paper, we develop a novel statistical framework tailored for early-phase translational combination therapy trials, with a focus on platform trial designs. Our methodology introduces a generalized"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03086","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2506.03086/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:15:14Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"cMzZPcprQW60wZALMiVyLCkKKaeNbWBeLLYBAezQYprtLTMICMOUho6WbiZd/dO25UWZD9lRQScJOFGUkEa3AQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-09T03:27:13.951867Z"},"content_sha256":"cc880f6314f0c323a85c12e060f93b7b603c922858736d57fd2bf3d41a3478c8","schema_version":"1.0","event_id":"sha256:cc880f6314f0c323a85c12e060f93b7b603c922858736d57fd2bf3d41a3478c8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/bundle.json","state_url":"https://pith.science/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-09T03:27:13Z","links":{"resolver":"https://pith.science/pith/GZTAUE76DJOE3C2TLSMZH5EZKO","bundle":"https://pith.science/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/bundle.json","state":"https://pith.science/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/state.json","well_known_bundle":"https://pith.science/.well-known/pith/GZTAUE76DJOE3C2TLSMZH5EZKO/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:GZTAUE76DJOE3C2TLSMZH5EZKO","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d4f8d39d56f22881e26c44b4254f6f9f6e865d3946b67c6af90d503948f8d12b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T17:10:49Z","title_canon_sha256":"51b14680759c327dbdfe2c96a063dd67dbd60ae625074c0929889014faf9bf11"},"schema_version":"1.0","source":{"id":"2506.03086","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.03086","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"arxiv_version","alias_value":"2506.03086v1","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.03086","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_12","alias_value":"GZTAUE76DJOE","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_16","alias_value":"GZTAUE76DJOE3C2T","created_at":"2026-07-05T11:15:14Z"},{"alias_kind":"pith_short_8","alias_value":"GZTAUE76","created_at":"2026-07-05T11:15:14Z"}],"graph_snapshots":[{"event_id":"sha256:cc880f6314f0c323a85c12e060f93b7b603c922858736d57fd2bf3d41a3478c8","target":"graph","created_at":"2026-07-05T11:15:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.03086/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Combination drug therapies hold significant promise for enhancing treatment efficacy, particularly in fields such as oncology, immunotherapy, and infectious diseases. However, designing clinical trials for these regimens poses unique statistical challenges due to multiple hypothesis testing, shared control groups, and overlapping treatment components that induce complex correlation structures. In this paper, we develop a novel statistical framework tailored for early-phase translational combination therapy trials, with a focus on platform trial designs. Our methodology introduces a generalized","authors_text":"Lin Wang, Man Mandy Jin, Nan Miles Xi, Xin Huang","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T17:10:49Z","title":"Synergy-Informed Design of Platform Trials for Combination Therapies"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.03086","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2f716306dc38ac92c36cef46f99eef875fc34f2869d38bf57cb6185fd40891cf","target":"record","created_at":"2026-07-05T11:15:14Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d4f8d39d56f22881e26c44b4254f6f9f6e865d3946b67c6af90d503948f8d12b","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"stat.ME","submitted_at":"2025-06-03T17:10:49Z","title_canon_sha256":"51b14680759c327dbdfe2c96a063dd67dbd60ae625074c0929889014faf9bf11"},"schema_version":"1.0","source":{"id":"2506.03086","kind":"arxiv","version":1}},"canonical_sha256":"36660a13fe1a5c4d8b535c9993f49953b222ddbc85988cbee0c0de95f466b379","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"36660a13fe1a5c4d8b535c9993f49953b222ddbc85988cbee0c0de95f466b379","first_computed_at":"2026-07-05T11:15:14.613974Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:15:14.613974Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"LRPrFmtrM0rbvddQJZ4UBNz/VNsIEmzP6e0+GL+tPu3de7MvKqShip3EofLKkI0zmvM+sAIwycCEFxgG6ZBdAw==","signature_status":"signed_v1","signed_at":"2026-07-05T11:15:14.614463Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.03086","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2f716306dc38ac92c36cef46f99eef875fc34f2869d38bf57cb6185fd40891cf","sha256:cc880f6314f0c323a85c12e060f93b7b603c922858736d57fd2bf3d41a3478c8"],"state_sha256":"eeecf667de8abde639bb81b4f038cf48fe62e616c031686eebf100d42161428b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EOJvbZTN6u83WG3KAj0OyQ53SzZbHZyEdriI8ItOeBGrKzprmIc3md9QeuJ6yiuUby097paHTqY41Gs0oavWDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-09T03:27:13.955425Z","bundle_sha256":"4abc31a04bfbae13f551ae057a9c86d3d5726a97f2e9b1efe4456211b915a21e"}}