{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:HA7W6H6VPP5TXSI2VV5T2YOCW7","short_pith_number":"pith:HA7W6H6V","canonical_record":{"source":{"id":"1510.03224","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-10-12T11:05:22Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"title_canon_sha256":"4fdc71164868f48a921fc729dc13ba1acbbb3479f1c9ac6a6c46e3c1f9833865","abstract_canon_sha256":"89ccd77c3c93256627de8d28c90b3419e674c0f6eba9da5a19abb50e298ffa69"},"schema_version":"1.0"},"canonical_sha256":"383f6f1fd57bfb3bc91aad7b3d61c2b7ceeea7a0da8948f76d6d6cd6050f23a6","source":{"kind":"arxiv","id":"1510.03224","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.03224","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"arxiv_version","alias_value":"1510.03224v1","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.03224","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"pith_short_12","alias_value":"HA7W6H6VPP5T","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"HA7W6H6VPP5TXSI2","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"HA7W6H6V","created_at":"2026-05-18T12:29:22Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:HA7W6H6VPP5TXSI2VV5T2YOCW7","target":"record","payload":{"canonical_record":{"source":{"id":"1510.03224","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-10-12T11:05:22Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"title_canon_sha256":"4fdc71164868f48a921fc729dc13ba1acbbb3479f1c9ac6a6c46e3c1f9833865","abstract_canon_sha256":"89ccd77c3c93256627de8d28c90b3419e674c0f6eba9da5a19abb50e298ffa69"},"schema_version":"1.0"},"canonical_sha256":"383f6f1fd57bfb3bc91aad7b3d61c2b7ceeea7a0da8948f76d6d6cd6050f23a6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:30:32.442674Z","signature_b64":"aaYKw/uUBQF1PflJCNL4Ht7n5a5Fna5TlgoTrgSIRtCFENmMjaLKgGU+tGETDU6yPWvUfJOnGm3ldZhADZjaDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"383f6f1fd57bfb3bc91aad7b3d61c2b7ceeea7a0da8948f76d6d6cd6050f23a6","last_reissued_at":"2026-05-18T01:30:32.442002Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:30:32.442002Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1510.03224","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:30:32Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TVNv38XsM+h2xryoAlWd99pylZW1PL5k+10JrpoFDqhvmb9WR7LEVE9bYa0ufgdaCRI9GuKP8dxbIR7bVDRnBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T13:11:51.921120Z"},"content_sha256":"0dce5454525ec544b8ee87943a6715311fa1ad2d68df0c7af19c37aae74a676d","schema_version":"1.0","event_id":"sha256:0dce5454525ec544b8ee87943a6715311fa1ad2d68df0c7af19c37aae74a676d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:HA7W6H6VPP5TXSI2VV5T2YOCW7","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.BM"],"primary_cat":"q-bio.QM","authors_text":"Alexander Schug, Herv\\'e Jacquier, Martin Weigt, Matteo Figliuzzi, Olivier Tenaillon","submitted_at":"2015-10-12T11:05:22Z","abstract_excerpt":"The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, e.g., of central importance for our understanding of the phenotypic effect of mutations related to disease and antibiotic drug resistance. Here we develop a novel inference scheme for mutational landscapes, which is based on the statistical analysis of large alignments of homologs of the protein of interest. Our method is able to capture epistatic couplings between residues, and therefore to assess the dependence of mutational effects on the sequence contex"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.03224","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:30:32Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"w2eNv/Aw16rDxSyW5JBk03ed4BR/9Iz/0Fd2mpLK++Bd4D3kdChtmJIJg6MRHymEO7ACRvfd5XiiWvqd+BXTAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T13:11:51.921580Z"},"content_sha256":"a89a2ddd1b3ab126ed4d98f686422778be30e430bf006c4feb9965bb147e38ef","schema_version":"1.0","event_id":"sha256:a89a2ddd1b3ab126ed4d98f686422778be30e430bf006c4feb9965bb147e38ef"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/bundle.json","state_url":"https://pith.science/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T13:11:51Z","links":{"resolver":"https://pith.science/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7","bundle":"https://pith.science/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/bundle.json","state":"https://pith.science/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HA7W6H6VPP5TXSI2VV5T2YOCW7/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:HA7W6H6VPP5TXSI2VV5T2YOCW7","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"89ccd77c3c93256627de8d28c90b3419e674c0f6eba9da5a19abb50e298ffa69","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-10-12T11:05:22Z","title_canon_sha256":"4fdc71164868f48a921fc729dc13ba1acbbb3479f1c9ac6a6c46e3c1f9833865"},"schema_version":"1.0","source":{"id":"1510.03224","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1510.03224","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"arxiv_version","alias_value":"1510.03224v1","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.03224","created_at":"2026-05-18T01:30:32Z"},{"alias_kind":"pith_short_12","alias_value":"HA7W6H6VPP5T","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_16","alias_value":"HA7W6H6VPP5TXSI2","created_at":"2026-05-18T12:29:22Z"},{"alias_kind":"pith_short_8","alias_value":"HA7W6H6V","created_at":"2026-05-18T12:29:22Z"}],"graph_snapshots":[{"event_id":"sha256:a89a2ddd1b3ab126ed4d98f686422778be30e430bf006c4feb9965bb147e38ef","target":"graph","created_at":"2026-05-18T01:30:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, e.g., of central importance for our understanding of the phenotypic effect of mutations related to disease and antibiotic drug resistance. Here we develop a novel inference scheme for mutational landscapes, which is based on the statistical analysis of large alignments of homologs of the protein of interest. Our method is able to capture epistatic couplings between residues, and therefore to assess the dependence of mutational effects on the sequence contex","authors_text":"Alexander Schug, Herv\\'e Jacquier, Martin Weigt, Matteo Figliuzzi, Olivier Tenaillon","cross_cats":["cond-mat.stat-mech","q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-10-12T11:05:22Z","title":"Coevolutionary landscape inference and the context-dependence of mutations in beta-lactamase TEM-1"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.03224","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:0dce5454525ec544b8ee87943a6715311fa1ad2d68df0c7af19c37aae74a676d","target":"record","created_at":"2026-05-18T01:30:32Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"89ccd77c3c93256627de8d28c90b3419e674c0f6eba9da5a19abb50e298ffa69","cross_cats_sorted":["cond-mat.stat-mech","q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2015-10-12T11:05:22Z","title_canon_sha256":"4fdc71164868f48a921fc729dc13ba1acbbb3479f1c9ac6a6c46e3c1f9833865"},"schema_version":"1.0","source":{"id":"1510.03224","kind":"arxiv","version":1}},"canonical_sha256":"383f6f1fd57bfb3bc91aad7b3d61c2b7ceeea7a0da8948f76d6d6cd6050f23a6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"383f6f1fd57bfb3bc91aad7b3d61c2b7ceeea7a0da8948f76d6d6cd6050f23a6","first_computed_at":"2026-05-18T01:30:32.442002Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:30:32.442002Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"aaYKw/uUBQF1PflJCNL4Ht7n5a5Fna5TlgoTrgSIRtCFENmMjaLKgGU+tGETDU6yPWvUfJOnGm3ldZhADZjaDg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:30:32.442674Z","signed_message":"canonical_sha256_bytes"},"source_id":"1510.03224","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:0dce5454525ec544b8ee87943a6715311fa1ad2d68df0c7af19c37aae74a676d","sha256:a89a2ddd1b3ab126ed4d98f686422778be30e430bf006c4feb9965bb147e38ef"],"state_sha256":"bfd8cd49f84394f6e019d157c68b0f699c1fe9e49a909a6b7cfeeabacf4f7c7c"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"LGwboUZXyCYpn0PlDOA2MYlKeFNSjvaMC/F+jSGt3OFhOzAphKmtU6glHcL3cc3QXZTWDKbCuDfLoBXhiSkHCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T13:11:51.924018Z","bundle_sha256":"f604eaa53b137dfcb543f252e4a23aa1a83ba4f04307bd96b1e8df2c2786e5fa"}}