{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:HFA6WRK42L2GCFEHIHDKVK4FV5","short_pith_number":"pith:HFA6WRK4","canonical_record":{"source":{"id":"1810.13268","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-10-31T13:17:20Z","cross_cats_sorted":[],"title_canon_sha256":"1dc92cc7a6a61290409294f1a0da2d7d586bffd2a80ba52127f51441461f465f","abstract_canon_sha256":"0ed8d52ea0bbd999db3b24ab8404764a18a2c08e28fc054e878f2e1b7f4f98fb"},"schema_version":"1.0"},"canonical_sha256":"3941eb455cd2f461148741c6aaab85af615d2635c0857b1869468e4a3d7758bc","source":{"kind":"arxiv","id":"1810.13268","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.13268","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"arxiv_version","alias_value":"1810.13268v1","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.13268","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"pith_short_12","alias_value":"HFA6WRK42L2G","created_at":"2026-05-18T12:32:28Z"},{"alias_kind":"pith_short_16","alias_value":"HFA6WRK42L2GCFEH","created_at":"2026-05-18T12:32:28Z"},{"alias_kind":"pith_short_8","alias_value":"HFA6WRK4","created_at":"2026-05-18T12:32:28Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:HFA6WRK42L2GCFEHIHDKVK4FV5","target":"record","payload":{"canonical_record":{"source":{"id":"1810.13268","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-10-31T13:17:20Z","cross_cats_sorted":[],"title_canon_sha256":"1dc92cc7a6a61290409294f1a0da2d7d586bffd2a80ba52127f51441461f465f","abstract_canon_sha256":"0ed8d52ea0bbd999db3b24ab8404764a18a2c08e28fc054e878f2e1b7f4f98fb"},"schema_version":"1.0"},"canonical_sha256":"3941eb455cd2f461148741c6aaab85af615d2635c0857b1869468e4a3d7758bc","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:01:49.843069Z","signature_b64":"nUUO72pMatlhmJwPTgJPpVYmdYHkZfRso6tUCU8NIzxpvOoTLCEANlcZ40XQ3P0fzoXDAY3uPZGHVYw+sBJiAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3941eb455cd2f461148741c6aaab85af615d2635c0857b1869468e4a3d7758bc","last_reissued_at":"2026-05-18T00:01:49.842413Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:01:49.842413Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1810.13268","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:01:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IjGLmZbTeuzyxiIaZhGZzHU3vvC7fcPtO1Zvk/Vp5j8+tPw7OR7S2P0nUtB1KKno9PKLvYLf3Xij5DJzY7RrBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:14:33.154476Z"},"content_sha256":"82034c725637e82f7da44960db75f84909a072efd3b1d0e6b11dfc08b187757d","schema_version":"1.0","event_id":"sha256:82034c725637e82f7da44960db75f84909a072efd3b1d0e6b11dfc08b187757d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:HFA6WRK42L2GCFEHIHDKVK4FV5","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Using Molecular Dynamics to Model the Binding Affinities of Nitrogen-Containing Bisphosphonates on Hydroxyapatite Surface","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.chem-ph","authors_text":"Tzu-Jen Lin","submitted_at":"2018-10-31T13:17:20Z","abstract_excerpt":"Nitrogen-containing bisphosphonates (NBPs) are widely used to treat bone density loss and skeletal disorders. The adsorption, retention, diffusion, and release of (NBPs) in bone minerals are governed by their binding affinities to such minerals. Extensive crystal growth, nuclear magnetic resonance (NMR), and isothermal titration calorimetry (ITC) studies have been conducted to measure the binding affinities of NBPs to bone minerals, but the results have been inconsistent. In this work, we examined the binding free energies of zoledronate (ZOL), risedronate (RIS), pamidronate (PAM), alendronate"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.13268","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:01:49Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vFzNAITTKlVLs9dOLrhW9efeCeWc+gF5brexBt6og9fJW+IgyNCPCaSgDP4aFQ07tVD0RNz/1lDMKNffGpoyAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-24T04:14:33.154824Z"},"content_sha256":"8ac5caae7cbae8f61fbc42b2a9afc6be6728f2476225f6adc28b550919ef488e","schema_version":"1.0","event_id":"sha256:8ac5caae7cbae8f61fbc42b2a9afc6be6728f2476225f6adc28b550919ef488e"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/bundle.json","state_url":"https://pith.science/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-24T04:14:33Z","links":{"resolver":"https://pith.science/pith/HFA6WRK42L2GCFEHIHDKVK4FV5","bundle":"https://pith.science/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/bundle.json","state":"https://pith.science/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HFA6WRK42L2GCFEHIHDKVK4FV5/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:HFA6WRK42L2GCFEHIHDKVK4FV5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"0ed8d52ea0bbd999db3b24ab8404764a18a2c08e28fc054e878f2e1b7f4f98fb","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-10-31T13:17:20Z","title_canon_sha256":"1dc92cc7a6a61290409294f1a0da2d7d586bffd2a80ba52127f51441461f465f"},"schema_version":"1.0","source":{"id":"1810.13268","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1810.13268","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"arxiv_version","alias_value":"1810.13268v1","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1810.13268","created_at":"2026-05-18T00:01:49Z"},{"alias_kind":"pith_short_12","alias_value":"HFA6WRK42L2G","created_at":"2026-05-18T12:32:28Z"},{"alias_kind":"pith_short_16","alias_value":"HFA6WRK42L2GCFEH","created_at":"2026-05-18T12:32:28Z"},{"alias_kind":"pith_short_8","alias_value":"HFA6WRK4","created_at":"2026-05-18T12:32:28Z"}],"graph_snapshots":[{"event_id":"sha256:8ac5caae7cbae8f61fbc42b2a9afc6be6728f2476225f6adc28b550919ef488e","target":"graph","created_at":"2026-05-18T00:01:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Nitrogen-containing bisphosphonates (NBPs) are widely used to treat bone density loss and skeletal disorders. The adsorption, retention, diffusion, and release of (NBPs) in bone minerals are governed by their binding affinities to such minerals. Extensive crystal growth, nuclear magnetic resonance (NMR), and isothermal titration calorimetry (ITC) studies have been conducted to measure the binding affinities of NBPs to bone minerals, but the results have been inconsistent. In this work, we examined the binding free energies of zoledronate (ZOL), risedronate (RIS), pamidronate (PAM), alendronate","authors_text":"Tzu-Jen Lin","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-10-31T13:17:20Z","title":"Using Molecular Dynamics to Model the Binding Affinities of Nitrogen-Containing Bisphosphonates on Hydroxyapatite Surface"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1810.13268","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:82034c725637e82f7da44960db75f84909a072efd3b1d0e6b11dfc08b187757d","target":"record","created_at":"2026-05-18T00:01:49Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"0ed8d52ea0bbd999db3b24ab8404764a18a2c08e28fc054e878f2e1b7f4f98fb","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-10-31T13:17:20Z","title_canon_sha256":"1dc92cc7a6a61290409294f1a0da2d7d586bffd2a80ba52127f51441461f465f"},"schema_version":"1.0","source":{"id":"1810.13268","kind":"arxiv","version":1}},"canonical_sha256":"3941eb455cd2f461148741c6aaab85af615d2635c0857b1869468e4a3d7758bc","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3941eb455cd2f461148741c6aaab85af615d2635c0857b1869468e4a3d7758bc","first_computed_at":"2026-05-18T00:01:49.842413Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:01:49.842413Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nUUO72pMatlhmJwPTgJPpVYmdYHkZfRso6tUCU8NIzxpvOoTLCEANlcZ40XQ3P0fzoXDAY3uPZGHVYw+sBJiAw==","signature_status":"signed_v1","signed_at":"2026-05-18T00:01:49.843069Z","signed_message":"canonical_sha256_bytes"},"source_id":"1810.13268","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:82034c725637e82f7da44960db75f84909a072efd3b1d0e6b11dfc08b187757d","sha256:8ac5caae7cbae8f61fbc42b2a9afc6be6728f2476225f6adc28b550919ef488e"],"state_sha256":"57a3de3229ec3013eba203c6c7e3f23907a5265d182e4a3df91ee5c4d4485252"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"IXhxCp7VeLiF/ENwFIMAfVF6ayUlEB0vkDSfzjzjvGc2O3V/YZBg703kz7dD1jrKP5GiK+SqE1y2yL0dOFuFDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-24T04:14:33.156797Z","bundle_sha256":"ee7eafb8b67d02420fc4be32d86758f19e4375f7ffc28b6d86d35165c1394802"}}