{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:HFEDYIJTT5FP26YSHA4MO4C34U","short_pith_number":"pith:HFEDYIJT","canonical_record":{"source":{"id":"2504.14274","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.AI","submitted_at":"2025-04-19T11:59:48Z","cross_cats_sorted":[],"title_canon_sha256":"92817fe88763a3350c2467c20d631ae52a45a0181e43ed6aac97a3e0d364e6c4","abstract_canon_sha256":"8eb6aeb9408a3631cf487672ec75f7f7bc1b3c90d09fac7a58a77c7993f4ec32"},"schema_version":"1.0"},"canonical_sha256":"39483c21339f4afd7b123838c7705be52acf05ed7759ad946a248ea001f332cb","source":{"kind":"arxiv","id":"2504.14274","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2504.14274","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"arxiv_version","alias_value":"2504.14274v1","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2504.14274","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_12","alias_value":"HFEDYIJTT5FP","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_16","alias_value":"HFEDYIJTT5FP26YS","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_8","alias_value":"HFEDYIJT","created_at":"2026-07-05T10:51:41Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:HFEDYIJTT5FP26YSHA4MO4C34U","target":"record","payload":{"canonical_record":{"source":{"id":"2504.14274","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.AI","submitted_at":"2025-04-19T11:59:48Z","cross_cats_sorted":[],"title_canon_sha256":"92817fe88763a3350c2467c20d631ae52a45a0181e43ed6aac97a3e0d364e6c4","abstract_canon_sha256":"8eb6aeb9408a3631cf487672ec75f7f7bc1b3c90d09fac7a58a77c7993f4ec32"},"schema_version":"1.0"},"canonical_sha256":"39483c21339f4afd7b123838c7705be52acf05ed7759ad946a248ea001f332cb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T10:51:41.003334Z","signature_b64":"lWCOmFgRBVC8d5TltuxQtsVN/ek8Vo2FNxPZ53PnYSPmoJ+DzUET0sNkecR2SQhOCbjeSzAK/kLu2gstR/FoAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"39483c21339f4afd7b123838c7705be52acf05ed7759ad946a248ea001f332cb","last_reissued_at":"2026-07-05T10:51:41.002819Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T10:51:41.002819Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2504.14274","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:51:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"CmcYmIAXElAVl3zW8u2gkFKoauPZjHvUR9NLjBHUrjNaH9YlckMNNz72WTYqZll5NGRjhhdAsYgqDjzm9A0nAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T19:14:22.771673Z"},"content_sha256":"704a98e4ab7f73f8efa6e78349fd78d1d806c65c0158daa8a195b8ed73dc7cc2","schema_version":"1.0","event_id":"sha256:704a98e4ab7f73f8efa6e78349fd78d1d806c65c0158daa8a195b8ed73dc7cc2"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:HFEDYIJTT5FP26YSHA4MO4C34U","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"ProtPainter: Draw or Drag Protein via Topology-guided Diffusion","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":[],"primary_cat":"cs.AI","authors_text":"Min Zhang, Shizhuo Cheng, Yan Zhang, Yuru Jiang, Zhengxi Lu","submitted_at":"2025-04-19T11:59:48Z","abstract_excerpt":"Recent advances in protein backbone generation have achieved promising results under structural, functional, or physical constraints. However, existing methods lack the flexibility for precise topology control, limiting navigation of the backbone space. We present ProtPainter, a diffusion-based approach for generating protein backbones conditioned on 3D curves. ProtPainter follows a two-stage process: curve-based sketching and sketch-guided backbone generation. For the first stage, we propose CurveEncoder, which predicts secondary structure annotations from a curve to parametrize sketch genera"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2504.14274","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2504.14274/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T10:51:41Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"eglcHfyfCpfpBqNzK7SV6MZNS0v2WDugUSmL5qx5ch2x47cWByMm/gmiblyAIkRxyM6FteBSq9CLro2WY9/wBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T19:14:22.772252Z"},"content_sha256":"9303d8d5c1b2711a5e7f7452c76dc52f5c93fd61d1298b0f78ea9e470d2c7764","schema_version":"1.0","event_id":"sha256:9303d8d5c1b2711a5e7f7452c76dc52f5c93fd61d1298b0f78ea9e470d2c7764"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HFEDYIJTT5FP26YSHA4MO4C34U/bundle.json","state_url":"https://pith.science/pith/HFEDYIJTT5FP26YSHA4MO4C34U/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HFEDYIJTT5FP26YSHA4MO4C34U/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-16T19:14:22Z","links":{"resolver":"https://pith.science/pith/HFEDYIJTT5FP26YSHA4MO4C34U","bundle":"https://pith.science/pith/HFEDYIJTT5FP26YSHA4MO4C34U/bundle.json","state":"https://pith.science/pith/HFEDYIJTT5FP26YSHA4MO4C34U/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HFEDYIJTT5FP26YSHA4MO4C34U/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:HFEDYIJTT5FP26YSHA4MO4C34U","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8eb6aeb9408a3631cf487672ec75f7f7bc1b3c90d09fac7a58a77c7993f4ec32","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.AI","submitted_at":"2025-04-19T11:59:48Z","title_canon_sha256":"92817fe88763a3350c2467c20d631ae52a45a0181e43ed6aac97a3e0d364e6c4"},"schema_version":"1.0","source":{"id":"2504.14274","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2504.14274","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"arxiv_version","alias_value":"2504.14274v1","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2504.14274","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_12","alias_value":"HFEDYIJTT5FP","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_16","alias_value":"HFEDYIJTT5FP26YS","created_at":"2026-07-05T10:51:41Z"},{"alias_kind":"pith_short_8","alias_value":"HFEDYIJT","created_at":"2026-07-05T10:51:41Z"}],"graph_snapshots":[{"event_id":"sha256:9303d8d5c1b2711a5e7f7452c76dc52f5c93fd61d1298b0f78ea9e470d2c7764","target":"graph","created_at":"2026-07-05T10:51:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2504.14274/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Recent advances in protein backbone generation have achieved promising results under structural, functional, or physical constraints. However, existing methods lack the flexibility for precise topology control, limiting navigation of the backbone space. We present ProtPainter, a diffusion-based approach for generating protein backbones conditioned on 3D curves. ProtPainter follows a two-stage process: curve-based sketching and sketch-guided backbone generation. For the first stage, we propose CurveEncoder, which predicts secondary structure annotations from a curve to parametrize sketch genera","authors_text":"Min Zhang, Shizhuo Cheng, Yan Zhang, Yuru Jiang, Zhengxi Lu","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.AI","submitted_at":"2025-04-19T11:59:48Z","title":"ProtPainter: Draw or Drag Protein via Topology-guided Diffusion"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2504.14274","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:704a98e4ab7f73f8efa6e78349fd78d1d806c65c0158daa8a195b8ed73dc7cc2","target":"record","created_at":"2026-07-05T10:51:41Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8eb6aeb9408a3631cf487672ec75f7f7bc1b3c90d09fac7a58a77c7993f4ec32","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"cs.AI","submitted_at":"2025-04-19T11:59:48Z","title_canon_sha256":"92817fe88763a3350c2467c20d631ae52a45a0181e43ed6aac97a3e0d364e6c4"},"schema_version":"1.0","source":{"id":"2504.14274","kind":"arxiv","version":1}},"canonical_sha256":"39483c21339f4afd7b123838c7705be52acf05ed7759ad946a248ea001f332cb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"39483c21339f4afd7b123838c7705be52acf05ed7759ad946a248ea001f332cb","first_computed_at":"2026-07-05T10:51:41.002819Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:51:41.002819Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"lWCOmFgRBVC8d5TltuxQtsVN/ek8Vo2FNxPZ53PnYSPmoJ+DzUET0sNkecR2SQhOCbjeSzAK/kLu2gstR/FoAw==","signature_status":"signed_v1","signed_at":"2026-07-05T10:51:41.003334Z","signed_message":"canonical_sha256_bytes"},"source_id":"2504.14274","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:704a98e4ab7f73f8efa6e78349fd78d1d806c65c0158daa8a195b8ed73dc7cc2","sha256:9303d8d5c1b2711a5e7f7452c76dc52f5c93fd61d1298b0f78ea9e470d2c7764"],"state_sha256":"60887430704602f4642ffa789665008190bac6bc700210dcc1cf7b67057f7426"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZnJhuff4NDw24bKRDRh6W1tTq85O1URc5LQTm3IW4E8h98x/t3mYR4MCdoOQjHVmj5LWjKV0Ga70qdhic4zyCA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-16T19:14:22.777291Z","bundle_sha256":"c9ed717bb140f8e533cf3f523b50274971ff24e8b0a22a0d80fd977edd83c75e"}}