{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2010:HHKVWBZR3THP4HHBRGFM7ECCGQ","short_pith_number":"pith:HHKVWBZR","canonical_record":{"source":{"id":"1001.1681","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2010-01-11T16:06:30Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"3fb080b3ef71a75d301d265986aed23216b345d2882c3548658774aba2d54772","abstract_canon_sha256":"57cefd5883137397997688dc5c3e5a51a0a31b8954435769ae23938124aeb1e2"},"schema_version":"1.0"},"canonical_sha256":"39d55b0731dccefe1ce1898acf9042341e096dd7270164948624bb7c67a93eb9","source":{"kind":"arxiv","id":"1001.1681","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1001.1681","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"arxiv_version","alias_value":"1001.1681v1","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1001.1681","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"pith_short_12","alias_value":"HHKVWBZR3THP","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"HHKVWBZR3THP4HHB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"HHKVWBZR","created_at":"2026-05-18T12:26:07Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2010:HHKVWBZR3THP4HHBRGFM7ECCGQ","target":"record","payload":{"canonical_record":{"source":{"id":"1001.1681","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2010-01-11T16:06:30Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"3fb080b3ef71a75d301d265986aed23216b345d2882c3548658774aba2d54772","abstract_canon_sha256":"57cefd5883137397997688dc5c3e5a51a0a31b8954435769ae23938124aeb1e2"},"schema_version":"1.0"},"canonical_sha256":"39d55b0731dccefe1ce1898acf9042341e096dd7270164948624bb7c67a93eb9","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:34:55.401239Z","signature_b64":"/Y+fgsxVSqkH6PHJxuUlqbQyASY8v90QDa2qZ8fGBzNKR6+iDP00dU8yQfjmhQ9Y6tHGkuNSCq+sRMjjp0sRDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"39d55b0731dccefe1ce1898acf9042341e096dd7270164948624bb7c67a93eb9","last_reissued_at":"2026-05-18T04:34:55.400766Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:34:55.400766Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1001.1681","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:34:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"pV+owKprrXfwuXjVQGXJ3R2rZjLDvrgOioC69T1wPt4vQ89yx4lp6B6kwA46wdz/XsZDutZIwCLjSmdaygcAAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T15:02:41.210993Z"},"content_sha256":"09136cb85b0ee4803bf000765e184742729a4b846802e547e20d3bdb7e85c46a","schema_version":"1.0","event_id":"sha256:09136cb85b0ee4803bf000765e184742729a4b846802e547e20d3bdb7e85c46a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2010:HHKVWBZR3THP4HHBRGFM7ECCGQ","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Multivariate dependence and genetic networks inference","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.QM","authors_text":"Adam A. Margolin, Andrea Califano, Ilya Nemenman, Kai Wang","submitted_at":"2010-01-11T16:06:30Z","abstract_excerpt":"A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods have been developed to use statistical correlations in high-throughput datasets to infer such interactions. However, cellular pathways are highly cooperative, often requiring the joint effect of many molecules, and few methods have been proposed to explicitly identify such higher-order interactions, partially due to the fact that the notion of multivariate statistical dependency itself remains imprecisely defined. We "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1001.1681","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:34:55Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mTmRrbpGbo30kIitJLagH2C9X9CWkqJq62i0wro9g3k6YLYD0idmZeODd0BMy6uwVThCX9mD6m2VMVHYhEunDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T15:02:41.211762Z"},"content_sha256":"3fd5026a9c51ec80e66e0d30963a5c7ace4d129779c0340afa50dfd7ddbe6786","schema_version":"1.0","event_id":"sha256:3fd5026a9c51ec80e66e0d30963a5c7ace4d129779c0340afa50dfd7ddbe6786"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/bundle.json","state_url":"https://pith.science/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T15:02:41Z","links":{"resolver":"https://pith.science/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ","bundle":"https://pith.science/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/bundle.json","state":"https://pith.science/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HHKVWBZR3THP4HHBRGFM7ECCGQ/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2010:HHKVWBZR3THP4HHBRGFM7ECCGQ","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"57cefd5883137397997688dc5c3e5a51a0a31b8954435769ae23938124aeb1e2","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2010-01-11T16:06:30Z","title_canon_sha256":"3fb080b3ef71a75d301d265986aed23216b345d2882c3548658774aba2d54772"},"schema_version":"1.0","source":{"id":"1001.1681","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1001.1681","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"arxiv_version","alias_value":"1001.1681v1","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1001.1681","created_at":"2026-05-18T04:34:55Z"},{"alias_kind":"pith_short_12","alias_value":"HHKVWBZR3THP","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_16","alias_value":"HHKVWBZR3THP4HHB","created_at":"2026-05-18T12:26:07Z"},{"alias_kind":"pith_short_8","alias_value":"HHKVWBZR","created_at":"2026-05-18T12:26:07Z"}],"graph_snapshots":[{"event_id":"sha256:3fd5026a9c51ec80e66e0d30963a5c7ace4d129779c0340afa50dfd7ddbe6786","target":"graph","created_at":"2026-05-18T04:34:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A critical task in systems biology is the identification of genes that interact to control cellular processes by transcriptional activation of a set of target genes. Many methods have been developed to use statistical correlations in high-throughput datasets to infer such interactions. However, cellular pathways are highly cooperative, often requiring the joint effect of many molecules, and few methods have been proposed to explicitly identify such higher-order interactions, partially due to the fact that the notion of multivariate statistical dependency itself remains imprecisely defined. We ","authors_text":"Adam A. Margolin, Andrea Califano, Ilya Nemenman, Kai Wang","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2010-01-11T16:06:30Z","title":"Multivariate dependence and genetic networks inference"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1001.1681","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:09136cb85b0ee4803bf000765e184742729a4b846802e547e20d3bdb7e85c46a","target":"record","created_at":"2026-05-18T04:34:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"57cefd5883137397997688dc5c3e5a51a0a31b8954435769ae23938124aeb1e2","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2010-01-11T16:06:30Z","title_canon_sha256":"3fb080b3ef71a75d301d265986aed23216b345d2882c3548658774aba2d54772"},"schema_version":"1.0","source":{"id":"1001.1681","kind":"arxiv","version":1}},"canonical_sha256":"39d55b0731dccefe1ce1898acf9042341e096dd7270164948624bb7c67a93eb9","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"39d55b0731dccefe1ce1898acf9042341e096dd7270164948624bb7c67a93eb9","first_computed_at":"2026-05-18T04:34:55.400766Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:34:55.400766Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/Y+fgsxVSqkH6PHJxuUlqbQyASY8v90QDa2qZ8fGBzNKR6+iDP00dU8yQfjmhQ9Y6tHGkuNSCq+sRMjjp0sRDg==","signature_status":"signed_v1","signed_at":"2026-05-18T04:34:55.401239Z","signed_message":"canonical_sha256_bytes"},"source_id":"1001.1681","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:09136cb85b0ee4803bf000765e184742729a4b846802e547e20d3bdb7e85c46a","sha256:3fd5026a9c51ec80e66e0d30963a5c7ace4d129779c0340afa50dfd7ddbe6786"],"state_sha256":"ff06edd570badb9e41c86da1f5619fc4ab202ac8be55388ff0b43ee5db933959"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"MUR07vviQGq28K3l3vMbuvhdOgBgTx2Wde0dNiiyCLIn9vl0ZdzE+wlrd20bF6mUDYMIBJnTtKBUHzLMUomJAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T15:02:41.215534Z","bundle_sha256":"f0f4ac6c07e241405e23951a5cb2ed70aae90497a5c23e5df22e866740acd6f6"}}