{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:HHY4AWDU4QQBF4S3XQMDBOKSCD","short_pith_number":"pith:HHY4AWDU","canonical_record":{"source":{"id":"1709.06720","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-09-20T04:31:26Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.CB"],"title_canon_sha256":"3363d98905d25509755c67a23450077791afbcfb910df8a7c9e61bb05ab927c4","abstract_canon_sha256":"b08becc1e03b552c492710fa02e16bbbdbccd49c4182631274f982c0c2e424a7"},"schema_version":"1.0"},"canonical_sha256":"39f1c05874e42012f25bbc1830b95210d5ff25ba49b074f6c0234abc9452edb1","source":{"kind":"arxiv","id":"1709.06720","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1709.06720","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"arxiv_version","alias_value":"1709.06720v1","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1709.06720","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"pith_short_12","alias_value":"HHY4AWDU4QQB","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_16","alias_value":"HHY4AWDU4QQBF4S3","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_8","alias_value":"HHY4AWDU","created_at":"2026-05-18T12:31:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:HHY4AWDU4QQBF4S3XQMDBOKSCD","target":"record","payload":{"canonical_record":{"source":{"id":"1709.06720","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-09-20T04:31:26Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.CB"],"title_canon_sha256":"3363d98905d25509755c67a23450077791afbcfb910df8a7c9e61bb05ab927c4","abstract_canon_sha256":"b08becc1e03b552c492710fa02e16bbbdbccd49c4182631274f982c0c2e424a7"},"schema_version":"1.0"},"canonical_sha256":"39f1c05874e42012f25bbc1830b95210d5ff25ba49b074f6c0234abc9452edb1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:29:59.856906Z","signature_b64":"CGL/YQG619z05XlpPvi5YNPNIWkyVBLtTFYmZ+7RDrS8xzGGVjBreuZeZJk6ZjBGRbv/GZAnqh7KwuMqBdtdCg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"39f1c05874e42012f25bbc1830b95210d5ff25ba49b074f6c0234abc9452edb1","last_reissued_at":"2026-05-18T00:29:59.856452Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:29:59.856452Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1709.06720","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:29:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"5atD9LIc958V9z4QVp4sZSi6McpziLYB4GuEhuWnKvs7vJpySa/wf4qGcwygGQBp+GXpkGKx5o7ml99CAtOkAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T10:32:38.925533Z"},"content_sha256":"1540a9b59c2b8a7b5d28130dbd860ccb5e9e747a1cc13caaa084d90b666fa8ad","schema_version":"1.0","event_id":"sha256:1540a9b59c2b8a7b5d28130dbd860ccb5e9e747a1cc13caaa084d90b666fa8ad"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:HHY4AWDU4QQBF4S3XQMDBOKSCD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.CB"],"primary_cat":"q-bio.QM","authors_text":"Joshua E. Schilling, Justin W. Nicholatos, Sergii Domanskyi, Sergiy Libert, Vladimir Privman","submitted_at":"2017-09-20T04:31:26Z","abstract_excerpt":"Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we characterize the progression of apoptosis in wild type and SIRT6 deficient mouse embryonic fibroblasts using time-lapse flow cytometry and computational modelling based on rate-equations and cell distribution analysis. We find that SIRT6 deficient cells resist apoptosis by delaying its initiation. I"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1709.06720","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:29:59Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Emz/YO5fnE1T4/4HuplZ1muVv/6FfBSiHs3eKubTG0XcFTS783H1HdYgJZh5RxKJVEMzuf7Om5QUjaZeMaJeDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T10:32:38.925884Z"},"content_sha256":"5477da43bfb75f0c4b22f709f91b7c35f93301a5068ae0a16ca556c03e444973","schema_version":"1.0","event_id":"sha256:5477da43bfb75f0c4b22f709f91b7c35f93301a5068ae0a16ca556c03e444973"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/bundle.json","state_url":"https://pith.science/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T10:32:38Z","links":{"resolver":"https://pith.science/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD","bundle":"https://pith.science/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/bundle.json","state":"https://pith.science/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HHY4AWDU4QQBF4S3XQMDBOKSCD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:HHY4AWDU4QQBF4S3XQMDBOKSCD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b08becc1e03b552c492710fa02e16bbbdbccd49c4182631274f982c0c2e424a7","cross_cats_sorted":["cond-mat.stat-mech","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-09-20T04:31:26Z","title_canon_sha256":"3363d98905d25509755c67a23450077791afbcfb910df8a7c9e61bb05ab927c4"},"schema_version":"1.0","source":{"id":"1709.06720","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1709.06720","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"arxiv_version","alias_value":"1709.06720v1","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1709.06720","created_at":"2026-05-18T00:29:59Z"},{"alias_kind":"pith_short_12","alias_value":"HHY4AWDU4QQB","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_16","alias_value":"HHY4AWDU4QQBF4S3","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_8","alias_value":"HHY4AWDU","created_at":"2026-05-18T12:31:18Z"}],"graph_snapshots":[{"event_id":"sha256:5477da43bfb75f0c4b22f709f91b7c35f93301a5068ae0a16ca556c03e444973","target":"graph","created_at":"2026-05-18T00:29:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Apoptosis is essential for numerous processes, such as development, resistance to infections, and suppression of tumorigenesis. Here, we investigate the influence of the nutrient sensing and longevity-assuring enzyme SIRT6 on the dynamics of apoptosis triggered by serum starvation. Specifically, we characterize the progression of apoptosis in wild type and SIRT6 deficient mouse embryonic fibroblasts using time-lapse flow cytometry and computational modelling based on rate-equations and cell distribution analysis. We find that SIRT6 deficient cells resist apoptosis by delaying its initiation. I","authors_text":"Joshua E. Schilling, Justin W. Nicholatos, Sergii Domanskyi, Sergiy Libert, Vladimir Privman","cross_cats":["cond-mat.stat-mech","q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-09-20T04:31:26Z","title":"SIRT6 Knockout Cells Resist Apoptosis Initiation but Not Progression: A Computational Method to Evaluate the Progression of Apoptosis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1709.06720","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:1540a9b59c2b8a7b5d28130dbd860ccb5e9e747a1cc13caaa084d90b666fa8ad","target":"record","created_at":"2026-05-18T00:29:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b08becc1e03b552c492710fa02e16bbbdbccd49c4182631274f982c0c2e424a7","cross_cats_sorted":["cond-mat.stat-mech","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2017-09-20T04:31:26Z","title_canon_sha256":"3363d98905d25509755c67a23450077791afbcfb910df8a7c9e61bb05ab927c4"},"schema_version":"1.0","source":{"id":"1709.06720","kind":"arxiv","version":1}},"canonical_sha256":"39f1c05874e42012f25bbc1830b95210d5ff25ba49b074f6c0234abc9452edb1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"39f1c05874e42012f25bbc1830b95210d5ff25ba49b074f6c0234abc9452edb1","first_computed_at":"2026-05-18T00:29:59.856452Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:29:59.856452Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"CGL/YQG619z05XlpPvi5YNPNIWkyVBLtTFYmZ+7RDrS8xzGGVjBreuZeZJk6ZjBGRbv/GZAnqh7KwuMqBdtdCg==","signature_status":"signed_v1","signed_at":"2026-05-18T00:29:59.856906Z","signed_message":"canonical_sha256_bytes"},"source_id":"1709.06720","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:1540a9b59c2b8a7b5d28130dbd860ccb5e9e747a1cc13caaa084d90b666fa8ad","sha256:5477da43bfb75f0c4b22f709f91b7c35f93301a5068ae0a16ca556c03e444973"],"state_sha256":"786723e63a7d7a0b2f93962829e14485a926d6022fb475f7d56f9996cc804373"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"DQgXWw/wNM/WPqhO0h+0wb9act12wkBbEwrQjX8pduzcSVW21qiq3SmtT3e3Mi9dfB+i/dkV/s8vht/AtfL5DQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T10:32:38.927880Z","bundle_sha256":"2584f4db622bf27da9dfcb156bf04dd82bc43baa817cf44db5d1d051aa954f10"}}