{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2022:HPHN7EM2CEXKQITR45ORI3OMRD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"571687d0d599a2d3ebaf28542b05bfe8954e58d49af5624eb10b50371345bdca","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2022-08-21T14:22:37Z","title_canon_sha256":"460d37408442e4abc4d7f56cca303dfcb9c3751ffc05b4bdff7fbadcae0e2e3a"},"schema_version":"1.0","source":{"id":"2208.09889","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2208.09889","created_at":"2026-07-05T05:31:53Z"},{"alias_kind":"arxiv_version","alias_value":"2208.09889v1","created_at":"2026-07-05T05:31:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2208.09889","created_at":"2026-07-05T05:31:53Z"},{"alias_kind":"pith_short_12","alias_value":"HPHN7EM2CEXK","created_at":"2026-07-05T05:31:53Z"},{"alias_kind":"pith_short_16","alias_value":"HPHN7EM2CEXKQITR","created_at":"2026-07-05T05:31:53Z"},{"alias_kind":"pith_short_8","alias_value":"HPHN7EM2","created_at":"2026-07-05T05:31:53Z"}],"graph_snapshots":[{"event_id":"sha256:acdcaadb3aec031881af5ffe95195e52d43234bc0c73a45c0a0474120ead4a75","target":"graph","created_at":"2026-07-05T05:31:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2208.09889/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Many genetic mutations adversely affect the structure and function of load-bearing soft tissues, with clinical sequelae often responsible for disability or death. Parallel advances in genetics and histomechanical characterization provide significant insight into these conditions, but there remains a pressing need to integrate such information. We present a novel genotype-to-biomechanical-phenotype neural network (G2{\\Phi}net) for characterizing and classifying biomechanical properties of soft tissues, which serve as important functional readouts of tissue health or disease. We illustrate the u","authors_text":"Bart Spronck, Enrui Zhang, George Em Karniadakis, Jay D. Humphrey","cross_cats":["cs.LG"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2022-08-21T14:22:37Z","title":"G2{\\Phi}net: Relating Genotype and Biomechanical Phenotype of Tissues with Deep Learning"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2208.09889","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:948f4e9b910df83fbb0f846ac00ecdb8ffda8284a5a69a5c2d21e2c531316c8d","target":"record","created_at":"2026-07-05T05:31:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"571687d0d599a2d3ebaf28542b05bfe8954e58d49af5624eb10b50371345bdca","cross_cats_sorted":["cs.LG"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.TO","submitted_at":"2022-08-21T14:22:37Z","title_canon_sha256":"460d37408442e4abc4d7f56cca303dfcb9c3751ffc05b4bdff7fbadcae0e2e3a"},"schema_version":"1.0","source":{"id":"2208.09889","kind":"arxiv","version":1}},"canonical_sha256":"3bcedf919a112ea82271e75d146dcc88db425f09bf426ecc7837f404cd762d7a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3bcedf919a112ea82271e75d146dcc88db425f09bf426ecc7837f404cd762d7a","first_computed_at":"2026-07-05T05:31:53.317514Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T05:31:53.317514Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Vv4x2Ze5DSCwMMcndL3sfE5FAZXg9UI9SQoSyRMnoLnBkGnnB9oz9fnqSeQcvcLPUZ2Zm2kiMQ6+JsTvkDlFAA==","signature_status":"signed_v1","signed_at":"2026-07-05T05:31:53.317899Z","signed_message":"canonical_sha256_bytes"},"source_id":"2208.09889","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:948f4e9b910df83fbb0f846ac00ecdb8ffda8284a5a69a5c2d21e2c531316c8d","sha256:acdcaadb3aec031881af5ffe95195e52d43234bc0c73a45c0a0474120ead4a75"],"state_sha256":"4a83b942bab656724f4eb4bde91db3d53b4be0ae83fe39e0c8d4006ce3117eac"}