{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:HQR3VRUGJUOKNNY4CCRMKZFSX3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"17b50e6c97fb976a269f5086c86cff27be17107110f5baf9806d44c7823c4337","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-30T10:50:19Z","title_canon_sha256":"0eeba25281f0b77b0d6debee17d8b3b37c7fba79159646515f6e7849226dd6d8"},"schema_version":"1.0","source":{"id":"1710.10861","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1710.10861","created_at":"2026-05-18T00:31:46Z"},{"alias_kind":"arxiv_version","alias_value":"1710.10861v1","created_at":"2026-05-18T00:31:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1710.10861","created_at":"2026-05-18T00:31:46Z"},{"alias_kind":"pith_short_12","alias_value":"HQR3VRUGJUOK","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_16","alias_value":"HQR3VRUGJUOKNNY4","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_8","alias_value":"HQR3VRUG","created_at":"2026-05-18T12:31:18Z"}],"graph_snapshots":[{"event_id":"sha256:afd34f035e7d59e47044d72c075326fb69709d6370cb7bdd4b420ab63728f6c3","target":"graph","created_at":"2026-05-18T00:31:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Oxidation-associated malondialdehyde (MDA) modification of proteins can generate immunogenic neo-epitopes that are recognized by autoantibodies. In health, IgM antibodies to MDA-adducts are part of the natural antibody pool, while elevated levels of IgG anti-MDA are associated with inflammatory conditions. Yet, in human autoimmune disease IgG anti-MDA responses have not been well characterized and their potential contribution to disease pathogenesis is not known. Here, we investigate MDA-modifications and anti-MDA-modified protein autoreactivity in rheumatoid arthritis (RA). While RA is primar","authors_text":"A. Jimmy Ytterberg, Akilan Krishnamurthy, Anca I. Catrina, Caroline Gronwall, Dagmar Scheel-Toellner, Gregg J. Silverman, Jeffrey D. Greenberg, Johanna Steen, Khaled Amara, Lars Klareskog, Marianne Engstrom, Meng Sun, Roman A. Zubarev, Uta Hardt, Vivianne Malmstrom","cross_cats":["q-bio.TO"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-30T10:50:19Z","title":"Autoreactivity to malondialdehyde-modifications in rheumatoid arthritis is linked to disease activity and synovial pathogenesis"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1710.10861","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a7defdadcb91f8981a022994ad9f448c39df453b15f2abbe09f43c43d0322513","target":"record","created_at":"2026-05-18T00:31:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"17b50e6c97fb976a269f5086c86cff27be17107110f5baf9806d44c7823c4337","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.BM","submitted_at":"2017-10-30T10:50:19Z","title_canon_sha256":"0eeba25281f0b77b0d6debee17d8b3b37c7fba79159646515f6e7849226dd6d8"},"schema_version":"1.0","source":{"id":"1710.10861","kind":"arxiv","version":1}},"canonical_sha256":"3c23bac6864d1ca6b71c10a2c564b2beeebebcbdebb1cccbd9ac88efb1661799","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3c23bac6864d1ca6b71c10a2c564b2beeebebcbdebb1cccbd9ac88efb1661799","first_computed_at":"2026-05-18T00:31:46.262036Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:31:46.262036Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Sp53W2R7TmmyH1u07cTx1D4a6urOIakHxFhg6SjVQU+c7H0UMJHrQOac+J5lTC/DfFKJNqwVXaJiIIc9hkLMAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:31:46.262580Z","signed_message":"canonical_sha256_bytes"},"source_id":"1710.10861","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a7defdadcb91f8981a022994ad9f448c39df453b15f2abbe09f43c43d0322513","sha256:afd34f035e7d59e47044d72c075326fb69709d6370cb7bdd4b420ab63728f6c3"],"state_sha256":"01371edab8c5400917cfc7593f866bda2e0160579cbf7c64f9b64a3f6d7f858b"}