{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2017:HRHWDKXQGNO23ZJDY6QTA76GAK","short_pith_number":"pith:HRHWDKXQ","canonical_record":{"source":{"id":"1704.05343","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-04-18T13:58:50Z","cross_cats_sorted":[],"title_canon_sha256":"9ead20ca9a3b1b94b7080e501a24817bc42e752de72bfa9423966e83b021a7b7","abstract_canon_sha256":"82628b3a3f49ca3ef13eae05e30c7e535a19d0a39ee0347f8ed9374e8505ada0"},"schema_version":"1.0"},"canonical_sha256":"3c4f61aaf0335dade523c7a1307fc602b915db836ce37d07282c420dc12d70d1","source":{"kind":"arxiv","id":"1704.05343","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.05343","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"arxiv_version","alias_value":"1704.05343v2","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.05343","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"pith_short_12","alias_value":"HRHWDKXQGNO2","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_16","alias_value":"HRHWDKXQGNO23ZJD","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_8","alias_value":"HRHWDKXQ","created_at":"2026-05-18T12:31:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2017:HRHWDKXQGNO23ZJDY6QTA76GAK","target":"record","payload":{"canonical_record":{"source":{"id":"1704.05343","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-04-18T13:58:50Z","cross_cats_sorted":[],"title_canon_sha256":"9ead20ca9a3b1b94b7080e501a24817bc42e752de72bfa9423966e83b021a7b7","abstract_canon_sha256":"82628b3a3f49ca3ef13eae05e30c7e535a19d0a39ee0347f8ed9374e8505ada0"},"schema_version":"1.0"},"canonical_sha256":"3c4f61aaf0335dade523c7a1307fc602b915db836ce37d07282c420dc12d70d1","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:45:53.780259Z","signature_b64":"NNn7VnvCC4SoYA+xlDJ/X6OL4v8vKJ5N4A3k9tWnWGfUYHQ9Cc7dvOqr3d/b+R50UzZm4MVhNP28Zt89hyOhDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3c4f61aaf0335dade523c7a1307fc602b915db836ce37d07282c420dc12d70d1","last_reissued_at":"2026-05-18T00:45:53.779620Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:45:53.779620Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1704.05343","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sFvsTw0hwzXwCOhQOTTKGlKSL/rSxVttA+0LTK3T2O0rR+DCsGPYfp70eaymB3Y30oBrQwOy+ncRSKJJnhMQBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T12:44:46.945923Z"},"content_sha256":"8178d401ea5d591459617e1f8d8b0a6a2cef3f091d43c3a6dda53f9aeb2dda33","schema_version":"1.0","event_id":"sha256:8178d401ea5d591459617e1f8d8b0a6a2cef3f091d43c3a6dda53f9aeb2dda33"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2017:HRHWDKXQGNO23ZJDY6QTA76GAK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"NetREX: Network Rewiring using EXpression - Towards Context Specific Regulatory Networks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Brian Oliver, Dong-Yeon Cho, Hangnoh Lee, Justin Fear, Teresa M Przytycka, Yijie Wang","submitted_at":"2017-04-18T13:58:50Z","abstract_excerpt":"Understanding gene regulation is a fundamental step towards understanding of how cells function and respond to environmental cues and perturbations. An important step in this direction is to infer the transcription factor-gene regulatory network (GRN). However gene regulatory networks are typically constructed disregarding the fact that regulatory programs are conditioned on tissue type, developmental stage, sex, and other factors. Collecting multitude of features required for a reliable construction of GRNs such as physical features and functional features for every context of interest is cos"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.05343","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T00:45:53Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"q38u18QD5oc5YLMuui0u9iGTDxYU3YrZhOx0380DGoO+TSiByUVksU9US56EN0rdBY6bvAEelqknosCaA1pkCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-01T12:44:46.946271Z"},"content_sha256":"6d95fb398c6eb4cd770ed53b7b7491d8c7d52a46e11a96636eccc2a6eef5bd24","schema_version":"1.0","event_id":"sha256:6d95fb398c6eb4cd770ed53b7b7491d8c7d52a46e11a96636eccc2a6eef5bd24"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/bundle.json","state_url":"https://pith.science/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-01T12:44:46Z","links":{"resolver":"https://pith.science/pith/HRHWDKXQGNO23ZJDY6QTA76GAK","bundle":"https://pith.science/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/bundle.json","state":"https://pith.science/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HRHWDKXQGNO23ZJDY6QTA76GAK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2017:HRHWDKXQGNO23ZJDY6QTA76GAK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"82628b3a3f49ca3ef13eae05e30c7e535a19d0a39ee0347f8ed9374e8505ada0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-04-18T13:58:50Z","title_canon_sha256":"9ead20ca9a3b1b94b7080e501a24817bc42e752de72bfa9423966e83b021a7b7"},"schema_version":"1.0","source":{"id":"1704.05343","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1704.05343","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"arxiv_version","alias_value":"1704.05343v2","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1704.05343","created_at":"2026-05-18T00:45:53Z"},{"alias_kind":"pith_short_12","alias_value":"HRHWDKXQGNO2","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_16","alias_value":"HRHWDKXQGNO23ZJD","created_at":"2026-05-18T12:31:18Z"},{"alias_kind":"pith_short_8","alias_value":"HRHWDKXQ","created_at":"2026-05-18T12:31:18Z"}],"graph_snapshots":[{"event_id":"sha256:6d95fb398c6eb4cd770ed53b7b7491d8c7d52a46e11a96636eccc2a6eef5bd24","target":"graph","created_at":"2026-05-18T00:45:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Understanding gene regulation is a fundamental step towards understanding of how cells function and respond to environmental cues and perturbations. An important step in this direction is to infer the transcription factor-gene regulatory network (GRN). However gene regulatory networks are typically constructed disregarding the fact that regulatory programs are conditioned on tissue type, developmental stage, sex, and other factors. Collecting multitude of features required for a reliable construction of GRNs such as physical features and functional features for every context of interest is cos","authors_text":"Brian Oliver, Dong-Yeon Cho, Hangnoh Lee, Justin Fear, Teresa M Przytycka, Yijie Wang","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-04-18T13:58:50Z","title":"NetREX: Network Rewiring using EXpression - Towards Context Specific Regulatory Networks"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1704.05343","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:8178d401ea5d591459617e1f8d8b0a6a2cef3f091d43c3a6dda53f9aeb2dda33","target":"record","created_at":"2026-05-18T00:45:53Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"82628b3a3f49ca3ef13eae05e30c7e535a19d0a39ee0347f8ed9374e8505ada0","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2017-04-18T13:58:50Z","title_canon_sha256":"9ead20ca9a3b1b94b7080e501a24817bc42e752de72bfa9423966e83b021a7b7"},"schema_version":"1.0","source":{"id":"1704.05343","kind":"arxiv","version":2}},"canonical_sha256":"3c4f61aaf0335dade523c7a1307fc602b915db836ce37d07282c420dc12d70d1","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3c4f61aaf0335dade523c7a1307fc602b915db836ce37d07282c420dc12d70d1","first_computed_at":"2026-05-18T00:45:53.779620Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:45:53.779620Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"NNn7VnvCC4SoYA+xlDJ/X6OL4v8vKJ5N4A3k9tWnWGfUYHQ9Cc7dvOqr3d/b+R50UzZm4MVhNP28Zt89hyOhDA==","signature_status":"signed_v1","signed_at":"2026-05-18T00:45:53.780259Z","signed_message":"canonical_sha256_bytes"},"source_id":"1704.05343","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:8178d401ea5d591459617e1f8d8b0a6a2cef3f091d43c3a6dda53f9aeb2dda33","sha256:6d95fb398c6eb4cd770ed53b7b7491d8c7d52a46e11a96636eccc2a6eef5bd24"],"state_sha256":"d4e76f32a5c104ca1145e2abddfd1b03e41ed0067cf3768c7a04b78c026b6872"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/U8HQ9MQdcu/E8QvvvmTdS0YBr5cQeIOnkbEOR1K5S6jbSEcLns6kGEH2h2zGqw/BdRYhtSV31zoiyXTiUavAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-01T12:44:46.948273Z","bundle_sha256":"3fd38ac80b4aaa5fc6b834a66c11b71b12bc9dc43f7ce5ab471785392a96e53e"}}