{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:HTR3XNLEIR7MJYPX5T4L657QVU","short_pith_number":"pith:HTR3XNLE","canonical_record":{"source":{"id":"1301.3981","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-01-17T04:51:07Z","cross_cats_sorted":[],"title_canon_sha256":"1abe855031271bfb8e7b2192e660e755d3b3ce2d877d7e54d5c26fbeca6ed717","abstract_canon_sha256":"1fd81016672a77f7fe41c8bc3b4a316114b7855df7f8ff34af528d5e144ff796"},"schema_version":"1.0"},"canonical_sha256":"3ce3bbb564447ec4e1f7ecf8bf77f0ad0d600ea192e61e62f521d5fd3fcf1719","source":{"kind":"arxiv","id":"1301.3981","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1301.3981","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"arxiv_version","alias_value":"1301.3981v1","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1301.3981","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"pith_short_12","alias_value":"HTR3XNLEIR7M","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_16","alias_value":"HTR3XNLEIR7MJYPX","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_8","alias_value":"HTR3XNLE","created_at":"2026-05-18T12:27:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:HTR3XNLEIR7MJYPX5T4L657QVU","target":"record","payload":{"canonical_record":{"source":{"id":"1301.3981","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-01-17T04:51:07Z","cross_cats_sorted":[],"title_canon_sha256":"1abe855031271bfb8e7b2192e660e755d3b3ce2d877d7e54d5c26fbeca6ed717","abstract_canon_sha256":"1fd81016672a77f7fe41c8bc3b4a316114b7855df7f8ff34af528d5e144ff796"},"schema_version":"1.0"},"canonical_sha256":"3ce3bbb564447ec4e1f7ecf8bf77f0ad0d600ea192e61e62f521d5fd3fcf1719","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:52:06.365237Z","signature_b64":"M+MP56KsOLo+saO+IZq4n/83R4OWqJ57TGTeTR9EQihoytNixbQnPLJ4H2QMyI6MjjwvQwDJkc5H9bzXkBUYAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3ce3bbb564447ec4e1f7ecf8bf77f0ad0d600ea192e61e62f521d5fd3fcf1719","last_reissued_at":"2026-05-18T01:52:06.364827Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:52:06.364827Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1301.3981","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:52:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TNinFHP8ga6oTQFwk9zEFRJIwAl8ubSXMpBWhCZ2pmsuwLRUSupbW9gdKbTIz8aklZb7R4Ii41kH68kGLa5ACQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T23:21:52.068833Z"},"content_sha256":"2fcad5291c5c9aa5a27a7c9a1238996912111edf71d1f0b9b08a1f9993a4c74a","schema_version":"1.0","event_id":"sha256:2fcad5291c5c9aa5a27a7c9a1238996912111edf71d1f0b9b08a1f9993a4c74a"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:HTR3XNLEIR7MJYPX5T4L657QVU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Evolution of molecular phenotypes under stabilizing selection","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.PE","authors_text":"Armita Nourmohammad, Michael Laessig, Stephan Schiffels","submitted_at":"2013-01-17T04:51:07Z","abstract_excerpt":"Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution builds on genome evolution in a complicated way, which involves selection, genetic drift, mutations and recombination. Here we develop a coarse-grained evolutionary statistics for phenotypes, which decouples from details of the underlying genotypes. We derive approximate evolution equations for the distribution of phenotype values within and across populations."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1301.3981","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:52:06Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"seaaqJY7DsETeLX2iVLFdzqrJA6YOPfNKmpmWihApQCS0d2Jge21CtlG2zcOZoF3BmeBG/X+70UY4HXO+rvGAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T23:21:52.069539Z"},"content_sha256":"d7e30b467f6e87f5b51d03eebda16cd4fb4b892bebed267d6c87880c8fe730d4","schema_version":"1.0","event_id":"sha256:d7e30b467f6e87f5b51d03eebda16cd4fb4b892bebed267d6c87880c8fe730d4"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HTR3XNLEIR7MJYPX5T4L657QVU/bundle.json","state_url":"https://pith.science/pith/HTR3XNLEIR7MJYPX5T4L657QVU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HTR3XNLEIR7MJYPX5T4L657QVU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-25T23:21:52Z","links":{"resolver":"https://pith.science/pith/HTR3XNLEIR7MJYPX5T4L657QVU","bundle":"https://pith.science/pith/HTR3XNLEIR7MJYPX5T4L657QVU/bundle.json","state":"https://pith.science/pith/HTR3XNLEIR7MJYPX5T4L657QVU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HTR3XNLEIR7MJYPX5T4L657QVU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:HTR3XNLEIR7MJYPX5T4L657QVU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"1fd81016672a77f7fe41c8bc3b4a316114b7855df7f8ff34af528d5e144ff796","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-01-17T04:51:07Z","title_canon_sha256":"1abe855031271bfb8e7b2192e660e755d3b3ce2d877d7e54d5c26fbeca6ed717"},"schema_version":"1.0","source":{"id":"1301.3981","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1301.3981","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"arxiv_version","alias_value":"1301.3981v1","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1301.3981","created_at":"2026-05-18T01:52:06Z"},{"alias_kind":"pith_short_12","alias_value":"HTR3XNLEIR7M","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_16","alias_value":"HTR3XNLEIR7MJYPX","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_8","alias_value":"HTR3XNLE","created_at":"2026-05-18T12:27:46Z"}],"graph_snapshots":[{"event_id":"sha256:d7e30b467f6e87f5b51d03eebda16cd4fb4b892bebed267d6c87880c8fe730d4","target":"graph","created_at":"2026-05-18T01:52:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Molecular phenotypes are important links between genomic information and organismic functions, fitness, and evolution. Complex phenotypes, which are also called quantitative traits, often depend on multiple genomic loci. Their evolution builds on genome evolution in a complicated way, which involves selection, genetic drift, mutations and recombination. Here we develop a coarse-grained evolutionary statistics for phenotypes, which decouples from details of the underlying genotypes. We derive approximate evolution equations for the distribution of phenotype values within and across populations.","authors_text":"Armita Nourmohammad, Michael Laessig, Stephan Schiffels","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-01-17T04:51:07Z","title":"Evolution of molecular phenotypes under stabilizing selection"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1301.3981","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2fcad5291c5c9aa5a27a7c9a1238996912111edf71d1f0b9b08a1f9993a4c74a","target":"record","created_at":"2026-05-18T01:52:06Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"1fd81016672a77f7fe41c8bc3b4a316114b7855df7f8ff34af528d5e144ff796","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.PE","submitted_at":"2013-01-17T04:51:07Z","title_canon_sha256":"1abe855031271bfb8e7b2192e660e755d3b3ce2d877d7e54d5c26fbeca6ed717"},"schema_version":"1.0","source":{"id":"1301.3981","kind":"arxiv","version":1}},"canonical_sha256":"3ce3bbb564447ec4e1f7ecf8bf77f0ad0d600ea192e61e62f521d5fd3fcf1719","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3ce3bbb564447ec4e1f7ecf8bf77f0ad0d600ea192e61e62f521d5fd3fcf1719","first_computed_at":"2026-05-18T01:52:06.364827Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:52:06.364827Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"M+MP56KsOLo+saO+IZq4n/83R4OWqJ57TGTeTR9EQihoytNixbQnPLJ4H2QMyI6MjjwvQwDJkc5H9bzXkBUYAA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:52:06.365237Z","signed_message":"canonical_sha256_bytes"},"source_id":"1301.3981","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2fcad5291c5c9aa5a27a7c9a1238996912111edf71d1f0b9b08a1f9993a4c74a","sha256:d7e30b467f6e87f5b51d03eebda16cd4fb4b892bebed267d6c87880c8fe730d4"],"state_sha256":"f101f0343e6ddd79ca20127da59b8900b16bb3649f6a48f5edcb48c3578919c1"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"60+Pp3s4RNzgFd2UmjpZ6DJK07ztyGavIpgDPMLJbZj7JlokufgCKF2O5Q0x6+umrihw56O4rkA8P05Td7wEAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-25T23:21:52.073071Z","bundle_sha256":"798f6cf3877a72337580459cd2b0b5ae980dd83644b629b41f9a455b40bb9600"}}