{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:HVT4OPWCPW27MIJXSUUZ44BPSR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"48819b2dbbd1c67608e49316f46d633884cce39478e422d77e9474180d439ed0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"stat.AP","submitted_at":"2025-02-13T17:39:28Z","title_canon_sha256":"70782792d3002cc133a0a9881e465ff45ace59c4d7dfd989e0d1e2f2589d790c"},"schema_version":"1.0","source":{"id":"2502.09527","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2502.09527","created_at":"2026-07-05T10:17:16Z"},{"alias_kind":"arxiv_version","alias_value":"2502.09527v1","created_at":"2026-07-05T10:17:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2502.09527","created_at":"2026-07-05T10:17:16Z"},{"alias_kind":"pith_short_12","alias_value":"HVT4OPWCPW27","created_at":"2026-07-05T10:17:16Z"},{"alias_kind":"pith_short_16","alias_value":"HVT4OPWCPW27MIJX","created_at":"2026-07-05T10:17:16Z"},{"alias_kind":"pith_short_8","alias_value":"HVT4OPWC","created_at":"2026-07-05T10:17:16Z"}],"graph_snapshots":[{"event_id":"sha256:4e926cd86626b7ea5766b51d175be66f0127ea30cd3066912b7a63e08de47125","target":"graph","created_at":"2026-07-05T10:17:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2502.09527/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Many pharmaceutical companies face concerns with the maintenance of desired revenue levels. Sales forecasts for the current portfolio of products and projects may indicate a decline in revenue as the marketed products approach patent expiry. To counteract the potential downturn in revenue, and to establish revenue growth, an in-flow of new projects into the development phases is required. In this article, we devise an approach with which the in-flow of new projects could be optimized, while adhering to the objectives and constraints set on revenue targets, budget limitations and strategic cons","authors_text":"Frank Miller, Magnus Ytterstad, Stig Johan Wiklund","cross_cats":[],"headline":"","license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"stat.AP","submitted_at":"2025-02-13T17:39:28Z","title":"Project portfolio planning in the pharmaceutical industry -- strategic objectives and quantitative optimization"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2502.09527","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2155958cd9680de7d6dbd79e87b40fd6be0a14c4b9ad853411b1ff4891ea6f84","target":"record","created_at":"2026-07-05T10:17:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"48819b2dbbd1c67608e49316f46d633884cce39478e422d77e9474180d439ed0","cross_cats_sorted":[],"license":"http://creativecommons.org/licenses/by-sa/4.0/","primary_cat":"stat.AP","submitted_at":"2025-02-13T17:39:28Z","title_canon_sha256":"70782792d3002cc133a0a9881e465ff45ace59c4d7dfd989e0d1e2f2589d790c"},"schema_version":"1.0","source":{"id":"2502.09527","kind":"arxiv","version":1}},"canonical_sha256":"3d67c73ec27db5f6213795299e702f9469a1808540efb79f0ca054977b184d27","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3d67c73ec27db5f6213795299e702f9469a1808540efb79f0ca054977b184d27","first_computed_at":"2026-07-05T10:17:16.958153Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T10:17:16.958153Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"hAvq0YcbPq8EI4alRQXdgpjgsgJRVgCqJPGqY7lAsua80zySZjJRzbL8dIXK52rt8CQXD+s82fcZ3dqdBl0wAA==","signature_status":"signed_v1","signed_at":"2026-07-05T10:17:16.958630Z","signed_message":"canonical_sha256_bytes"},"source_id":"2502.09527","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2155958cd9680de7d6dbd79e87b40fd6be0a14c4b9ad853411b1ff4891ea6f84","sha256:4e926cd86626b7ea5766b51d175be66f0127ea30cd3066912b7a63e08de47125"],"state_sha256":"6b15c7de3171a5aa1da30df9c19b0041f6c3244be61ea94e363fa2cc09c047e1"}