{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:HVXMANMCKE3DCODUKQMZTPES2Y","short_pith_number":"pith:HVXMANMC","canonical_record":{"source":{"id":"1905.12179","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.PE","submitted_at":"2019-05-29T02:21:04Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"de8cb2e3c20f146a7f24ad6e7cac3effcfaa41bec50e16dc0168205f83230a39","abstract_canon_sha256":"e1f1c4cf5833ca9d640b02a8b9eb3dd1d9407875811588a4e1d499a6a0f39919"},"schema_version":"1.0"},"canonical_sha256":"3d6ec035825136313874541999bc92d6214dda5248edbd96b4b7fa208084e774","source":{"kind":"arxiv","id":"1905.12179","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1905.12179","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"arxiv_version","alias_value":"1905.12179v1","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1905.12179","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"pith_short_12","alias_value":"HVXMANMCKE3D","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"HVXMANMCKE3DCODU","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"HVXMANMC","created_at":"2026-05-18T12:33:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:HVXMANMCKE3DCODUKQMZTPES2Y","target":"record","payload":{"canonical_record":{"source":{"id":"1905.12179","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.PE","submitted_at":"2019-05-29T02:21:04Z","cross_cats_sorted":["q-bio.TO"],"title_canon_sha256":"de8cb2e3c20f146a7f24ad6e7cac3effcfaa41bec50e16dc0168205f83230a39","abstract_canon_sha256":"e1f1c4cf5833ca9d640b02a8b9eb3dd1d9407875811588a4e1d499a6a0f39919"},"schema_version":"1.0"},"canonical_sha256":"3d6ec035825136313874541999bc92d6214dda5248edbd96b4b7fa208084e774","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:44:46.893505Z","signature_b64":"LxLdyqtl8TqPLHuALDVVDK101uq1zV0oLuUn3g+N5u7HroUZEzU3w3I7EMRo2Ch5PDPCrlBWnKXc/BxTPBZWDQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3d6ec035825136313874541999bc92d6214dda5248edbd96b4b7fa208084e774","last_reissued_at":"2026-05-17T23:44:46.892957Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:44:46.892957Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1905.12179","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:44:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"zf8ZKD7eyppZyXTXTPKXLIAZyRM1SKJS4mzBjEjOrExASsDrz/gZsoNhcA6e3etHjmI8jgeNrYVGpH8/q8qLAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T02:22:59.993515Z"},"content_sha256":"51d585e69cf3b145f31705ba5bda977ce9d0fd85f2515fe7f6bb493e421744c6","schema_version":"1.0","event_id":"sha256:51d585e69cf3b145f31705ba5bda977ce9d0fd85f2515fe7f6bb493e421744c6"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:HVXMANMCKE3DCODUKQMZTPES2Y","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Dynamics of T Cell Receptor Distributions Following Acute Thymic Atrophy and Resumption","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.TO"],"primary_cat":"q-bio.PE","authors_text":"Stephanie M. Lewkiewicz, Tom Chou, Yao-Li Chuang","submitted_at":"2019-05-29T02:21:04Z","abstract_excerpt":"Naive human T cells are produced in the thymus, which atrophies abruptly and severely in response to physical or psychological stress. To understand how an instance of stress affects the size and \"diversity\" of the peripheral naive T cell pool, we derive a mean-field autonomous ODE model of T cell replenishment that allows us to track the clone abundance distribution (the mean number of different TCRs each represented by a specific number of cells). We identify equilibrium solutions that arise at different rates of T cell production, and derive analytic approximations to the dominant eigenvalu"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1905.12179","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:44:46Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"x4WVIHGu3Upp++3dRWCOnFC1V22ZWXOTR4uM62VqZ7Yu1PH40h1EZg3nTaHBxGt/U1b50WXcThGhLEaUP2EJBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T02:22:59.994201Z"},"content_sha256":"cc04f1d501354e560f4a705d494ea0eb9707829851aaf04f03f1efa9c4d26f75","schema_version":"1.0","event_id":"sha256:cc04f1d501354e560f4a705d494ea0eb9707829851aaf04f03f1efa9c4d26f75"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HVXMANMCKE3DCODUKQMZTPES2Y/bundle.json","state_url":"https://pith.science/pith/HVXMANMCKE3DCODUKQMZTPES2Y/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HVXMANMCKE3DCODUKQMZTPES2Y/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T02:22:59Z","links":{"resolver":"https://pith.science/pith/HVXMANMCKE3DCODUKQMZTPES2Y","bundle":"https://pith.science/pith/HVXMANMCKE3DCODUKQMZTPES2Y/bundle.json","state":"https://pith.science/pith/HVXMANMCKE3DCODUKQMZTPES2Y/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HVXMANMCKE3DCODUKQMZTPES2Y/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:HVXMANMCKE3DCODUKQMZTPES2Y","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"e1f1c4cf5833ca9d640b02a8b9eb3dd1d9407875811588a4e1d499a6a0f39919","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.PE","submitted_at":"2019-05-29T02:21:04Z","title_canon_sha256":"de8cb2e3c20f146a7f24ad6e7cac3effcfaa41bec50e16dc0168205f83230a39"},"schema_version":"1.0","source":{"id":"1905.12179","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1905.12179","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"arxiv_version","alias_value":"1905.12179v1","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1905.12179","created_at":"2026-05-17T23:44:46Z"},{"alias_kind":"pith_short_12","alias_value":"HVXMANMCKE3D","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"HVXMANMCKE3DCODU","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"HVXMANMC","created_at":"2026-05-18T12:33:18Z"}],"graph_snapshots":[{"event_id":"sha256:cc04f1d501354e560f4a705d494ea0eb9707829851aaf04f03f1efa9c4d26f75","target":"graph","created_at":"2026-05-17T23:44:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Naive human T cells are produced in the thymus, which atrophies abruptly and severely in response to physical or psychological stress. To understand how an instance of stress affects the size and \"diversity\" of the peripheral naive T cell pool, we derive a mean-field autonomous ODE model of T cell replenishment that allows us to track the clone abundance distribution (the mean number of different TCRs each represented by a specific number of cells). We identify equilibrium solutions that arise at different rates of T cell production, and derive analytic approximations to the dominant eigenvalu","authors_text":"Stephanie M. Lewkiewicz, Tom Chou, Yao-Li Chuang","cross_cats":["q-bio.TO"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.PE","submitted_at":"2019-05-29T02:21:04Z","title":"Dynamics of T Cell Receptor Distributions Following Acute Thymic Atrophy and Resumption"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1905.12179","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:51d585e69cf3b145f31705ba5bda977ce9d0fd85f2515fe7f6bb493e421744c6","target":"record","created_at":"2026-05-17T23:44:46Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"e1f1c4cf5833ca9d640b02a8b9eb3dd1d9407875811588a4e1d499a6a0f39919","cross_cats_sorted":["q-bio.TO"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.PE","submitted_at":"2019-05-29T02:21:04Z","title_canon_sha256":"de8cb2e3c20f146a7f24ad6e7cac3effcfaa41bec50e16dc0168205f83230a39"},"schema_version":"1.0","source":{"id":"1905.12179","kind":"arxiv","version":1}},"canonical_sha256":"3d6ec035825136313874541999bc92d6214dda5248edbd96b4b7fa208084e774","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3d6ec035825136313874541999bc92d6214dda5248edbd96b4b7fa208084e774","first_computed_at":"2026-05-17T23:44:46.892957Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:44:46.892957Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"LxLdyqtl8TqPLHuALDVVDK101uq1zV0oLuUn3g+N5u7HroUZEzU3w3I7EMRo2Ch5PDPCrlBWnKXc/BxTPBZWDQ==","signature_status":"signed_v1","signed_at":"2026-05-17T23:44:46.893505Z","signed_message":"canonical_sha256_bytes"},"source_id":"1905.12179","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:51d585e69cf3b145f31705ba5bda977ce9d0fd85f2515fe7f6bb493e421744c6","sha256:cc04f1d501354e560f4a705d494ea0eb9707829851aaf04f03f1efa9c4d26f75"],"state_sha256":"1ef7034dc08ce628887017bcfa37cd3790203c10870d013a304ed63a6f136180"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QjHdRvtOST8xP5HoBOM/dARh4evdu7KAHfGFSxNchjjcJ6K1mHf8J/2j4gHjJg9TXdqGQOebkuf7nzIynhKJDA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T02:22:59.998136Z","bundle_sha256":"52562e107f6c678c03e8ab544d7ceccae6f6c240dabe137c65f6b220e80ca8dd"}}