{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:HWVOFCGZ7RM4YTQVRBXS3DKJRT","short_pith_number":"pith:HWVOFCGZ","canonical_record":{"source":{"id":"1901.09861","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-28T18:07:46Z","cross_cats_sorted":["cs.SI"],"title_canon_sha256":"58355a2daa4f00ba6ed81a3e74a273b175f43b8784b400853f20c3b0cc944a69","abstract_canon_sha256":"13a4ee772dbc8fec28863a96a2ca1f25785026a700371c2a8325e839a02f4e24"},"schema_version":"1.0"},"canonical_sha256":"3daae288d9fc59cc4e15886f2d8d498cf5ea4c13d5e97fade66843ee81a90535","source":{"kind":"arxiv","id":"1901.09861","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.09861","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"arxiv_version","alias_value":"1901.09861v1","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.09861","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"pith_short_12","alias_value":"HWVOFCGZ7RM4","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"HWVOFCGZ7RM4YTQV","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"HWVOFCGZ","created_at":"2026-05-18T12:33:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:HWVOFCGZ7RM4YTQVRBXS3DKJRT","target":"record","payload":{"canonical_record":{"source":{"id":"1901.09861","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-28T18:07:46Z","cross_cats_sorted":["cs.SI"],"title_canon_sha256":"58355a2daa4f00ba6ed81a3e74a273b175f43b8784b400853f20c3b0cc944a69","abstract_canon_sha256":"13a4ee772dbc8fec28863a96a2ca1f25785026a700371c2a8325e839a02f4e24"},"schema_version":"1.0"},"canonical_sha256":"3daae288d9fc59cc4e15886f2d8d498cf5ea4c13d5e97fade66843ee81a90535","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:55:23.636541Z","signature_b64":"vcSaAlAx9cqH0k/4zIcSbblmAOMfy0q71n1x3DxMfx8gZpWAMrRv3DMWVt5o/8m20adQmuBFVMvCy7epEFrCAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"3daae288d9fc59cc4e15886f2d8d498cf5ea4c13d5e97fade66843ee81a90535","last_reissued_at":"2026-05-17T23:55:23.636124Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:55:23.636124Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1901.09861","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:55:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"M2cBbVtkyI2Yx8SJdFwoTNewE8t/R305I9h+hXLXwPipdwtBeW09mruDtKrPG42nMTm5RHKEzQDJJUo5FLRBDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T23:02:02.304005Z"},"content_sha256":"f51260779ad9d2b557f35d36aa88226c3c88f013d3c3969532a1d45e8e7a62ea","schema_version":"1.0","event_id":"sha256:f51260779ad9d2b557f35d36aa88226c3c88f013d3c3969532a1d45e8e7a62ea"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:HWVOFCGZ7RM4YTQVRBXS3DKJRT","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Tumor Connectomics: Mapping the intra-tumoral complex interaction network","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.SI"],"primary_cat":"q-bio.QM","authors_text":"Michael A. Jacobs, Vishwa S. Parekh","submitted_at":"2019-01-28T18:07:46Z","abstract_excerpt":"Tumors are extremely heterogeneous and comprise of a number of intratumor microenvironments or sub-regions. These tumor microenvironments may interact with eac based on complex high-level relationships, which could provide important insight into the organizational structure of the tumor network. To that end, we developed a tumor connectomics framework (TCF) to understand and model the complex functional and morphological interactions within the tumor. Then, we demonstrate the TCF's potential in predicting treatment response in breast cancer patients being treated with neoadjuvant chemotherapy."},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.09861","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:55:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"YmngaXRms0rirfrNSgAfmr8dBCsqBkF5qJOSgu/XyRZEYyOrQXGYj4oO0+1xNaPaIhP0T4970f8xQhz7UyrWBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T23:02:02.304644Z"},"content_sha256":"5918c9261dd86078c1625bc7fa117a8b99f7bb5c6a339bc96dbbbf4e2b64b878","schema_version":"1.0","event_id":"sha256:5918c9261dd86078c1625bc7fa117a8b99f7bb5c6a339bc96dbbbf4e2b64b878"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/bundle.json","state_url":"https://pith.science/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T23:02:02Z","links":{"resolver":"https://pith.science/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT","bundle":"https://pith.science/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/bundle.json","state":"https://pith.science/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/state.json","well_known_bundle":"https://pith.science/.well-known/pith/HWVOFCGZ7RM4YTQVRBXS3DKJRT/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:HWVOFCGZ7RM4YTQVRBXS3DKJRT","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"13a4ee772dbc8fec28863a96a2ca1f25785026a700371c2a8325e839a02f4e24","cross_cats_sorted":["cs.SI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-28T18:07:46Z","title_canon_sha256":"58355a2daa4f00ba6ed81a3e74a273b175f43b8784b400853f20c3b0cc944a69"},"schema_version":"1.0","source":{"id":"1901.09861","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1901.09861","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"arxiv_version","alias_value":"1901.09861v1","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1901.09861","created_at":"2026-05-17T23:55:23Z"},{"alias_kind":"pith_short_12","alias_value":"HWVOFCGZ7RM4","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"HWVOFCGZ7RM4YTQV","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"HWVOFCGZ","created_at":"2026-05-18T12:33:18Z"}],"graph_snapshots":[{"event_id":"sha256:5918c9261dd86078c1625bc7fa117a8b99f7bb5c6a339bc96dbbbf4e2b64b878","target":"graph","created_at":"2026-05-17T23:55:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Tumors are extremely heterogeneous and comprise of a number of intratumor microenvironments or sub-regions. These tumor microenvironments may interact with eac based on complex high-level relationships, which could provide important insight into the organizational structure of the tumor network. To that end, we developed a tumor connectomics framework (TCF) to understand and model the complex functional and morphological interactions within the tumor. Then, we demonstrate the TCF's potential in predicting treatment response in breast cancer patients being treated with neoadjuvant chemotherapy.","authors_text":"Michael A. Jacobs, Vishwa S. Parekh","cross_cats":["cs.SI"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-28T18:07:46Z","title":"Tumor Connectomics: Mapping the intra-tumoral complex interaction network"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1901.09861","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f51260779ad9d2b557f35d36aa88226c3c88f013d3c3969532a1d45e8e7a62ea","target":"record","created_at":"2026-05-17T23:55:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"13a4ee772dbc8fec28863a96a2ca1f25785026a700371c2a8325e839a02f4e24","cross_cats_sorted":["cs.SI"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-01-28T18:07:46Z","title_canon_sha256":"58355a2daa4f00ba6ed81a3e74a273b175f43b8784b400853f20c3b0cc944a69"},"schema_version":"1.0","source":{"id":"1901.09861","kind":"arxiv","version":1}},"canonical_sha256":"3daae288d9fc59cc4e15886f2d8d498cf5ea4c13d5e97fade66843ee81a90535","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3daae288d9fc59cc4e15886f2d8d498cf5ea4c13d5e97fade66843ee81a90535","first_computed_at":"2026-05-17T23:55:23.636124Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:55:23.636124Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"vcSaAlAx9cqH0k/4zIcSbblmAOMfy0q71n1x3DxMfx8gZpWAMrRv3DMWVt5o/8m20adQmuBFVMvCy7epEFrCAg==","signature_status":"signed_v1","signed_at":"2026-05-17T23:55:23.636541Z","signed_message":"canonical_sha256_bytes"},"source_id":"1901.09861","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f51260779ad9d2b557f35d36aa88226c3c88f013d3c3969532a1d45e8e7a62ea","sha256:5918c9261dd86078c1625bc7fa117a8b99f7bb5c6a339bc96dbbbf4e2b64b878"],"state_sha256":"630c737bc138e12eb99b63f4eed437e41cb3d0f8cf8235b6fc1a3ffc04c04f29"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"nMXAMmxrArtdzgHeP9Mde2QVD8x01Ih+AyREnEvnV7DG8dOn30RmCXASlNV2kAkCUOzxz7cB2WFV738oDKzmAA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T23:02:02.308006Z","bundle_sha256":"ae5e9e237c60b72999f894ae32e6eadcb212a90f5cd6c5bb01a48f13c3d06777"}}