{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:HYD667ZGF7SJOUOAO4LFWAG6V3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"ba00d679cc6acb6dbd27a436648ef84aca8b1b4c4af50c1c96a12eed08dfc9e8","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-09-05T10:47:49Z","title_canon_sha256":"47d924454fa66313310fc2132fdf54cce376eff679615b853e786ab37962341a"},"schema_version":"1.0","source":{"id":"2509.04998","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2509.04998","created_at":"2026-07-05T12:05:34Z"},{"alias_kind":"arxiv_version","alias_value":"2509.04998v1","created_at":"2026-07-05T12:05:34Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2509.04998","created_at":"2026-07-05T12:05:34Z"},{"alias_kind":"pith_short_12","alias_value":"HYD667ZGF7SJ","created_at":"2026-07-05T12:05:34Z"},{"alias_kind":"pith_short_16","alias_value":"HYD667ZGF7SJOUOA","created_at":"2026-07-05T12:05:34Z"},{"alias_kind":"pith_short_8","alias_value":"HYD667ZG","created_at":"2026-07-05T12:05:34Z"}],"graph_snapshots":[{"event_id":"sha256:8f9eefec4b514c71c87947568358f71547b9ddc5dac39b9fd4d7647f96c60cf3","target":"graph","created_at":"2026-07-05T12:05:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2509.04998/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Directed evolution is an iterative laboratory process of designing proteins with improved function by iteratively synthesizing new protein variants and evaluating their desired property with expensive and time-consuming biochemical screening. Machine learning methods can help select informative or promising variants for screening to increase their quality and reduce the amount of necessary screening. In this paper, we present a novel method for machine-learning-assisted directed evolution of proteins which combines Bayesian optimization with informative representation of protein variants extra","authors_text":"Ji\\v{r}\\'i Kl\\'ema, Matou\\v{s} Sold\\'at","cross_cats":["q-bio.BM"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-09-05T10:47:49Z","title":"Directed Evolution of Proteins via Bayesian Optimization in Embedding Space"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2509.04998","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:4dcada5cfaf9f12fed5bfa9994d48942dba8b30309a625f18fcd39913259987e","target":"record","created_at":"2026-07-05T12:05:34Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"ba00d679cc6acb6dbd27a436648ef84aca8b1b4c4af50c1c96a12eed08dfc9e8","cross_cats_sorted":["q-bio.BM"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-09-05T10:47:49Z","title_canon_sha256":"47d924454fa66313310fc2132fdf54cce376eff679615b853e786ab37962341a"},"schema_version":"1.0","source":{"id":"2509.04998","kind":"arxiv","version":1}},"canonical_sha256":"3e07ef7f262fe49751c077165b00deaec844008f6c43b6e488f0183485453d2c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"3e07ef7f262fe49751c077165b00deaec844008f6c43b6e488f0183485453d2c","first_computed_at":"2026-07-05T12:05:34.197133Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T12:05:34.197133Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VbA5KRS2R5Bic2dyVlMGNpyIRjzZYkyqyKbFv7xEf7hfZv0hp7+GdUDWhweWZVt+YJIWUC6SLbOQJPCROFK9Bw==","signature_status":"signed_v1","signed_at":"2026-07-05T12:05:34.197627Z","signed_message":"canonical_sha256_bytes"},"source_id":"2509.04998","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:4dcada5cfaf9f12fed5bfa9994d48942dba8b30309a625f18fcd39913259987e","sha256:8f9eefec4b514c71c87947568358f71547b9ddc5dac39b9fd4d7647f96c60cf3"],"state_sha256":"26f7b8792e0fb1117b0343efa9cbf23b53df8411d5261acd0e2cbf30b576abf6"}