{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:IAYNDBDQ6FJYJAGG7CUMUXYXIK","short_pith_number":"pith:IAYNDBDQ","canonical_record":{"source":{"id":"1512.05758","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2015-01-06T16:15:51Z","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"title_canon_sha256":"6daa5ce2b27cc3c560b0b4711d711626d9bd6f5f8a55674ca2471e2a267b6183","abstract_canon_sha256":"df662ce7a2f4f9a63103b646c1dcaa88e841e3020c8d84e84ac02768a1306a7d"},"schema_version":"1.0"},"canonical_sha256":"4030d18470f1538480c6f8a8ca5f17429dc59be7d9077b30c93be517d6c49a35","source":{"kind":"arxiv","id":"1512.05758","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.05758","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"arxiv_version","alias_value":"1512.05758v2","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.05758","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"pith_short_12","alias_value":"IAYNDBDQ6FJY","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_16","alias_value":"IAYNDBDQ6FJYJAGG","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_8","alias_value":"IAYNDBDQ","created_at":"2026-05-18T12:29:25Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:IAYNDBDQ6FJYJAGG7CUMUXYXIK","target":"record","payload":{"canonical_record":{"source":{"id":"1512.05758","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2015-01-06T16:15:51Z","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"title_canon_sha256":"6daa5ce2b27cc3c560b0b4711d711626d9bd6f5f8a55674ca2471e2a267b6183","abstract_canon_sha256":"df662ce7a2f4f9a63103b646c1dcaa88e841e3020c8d84e84ac02768a1306a7d"},"schema_version":"1.0"},"canonical_sha256":"4030d18470f1538480c6f8a8ca5f17429dc59be7d9077b30c93be517d6c49a35","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:17:36.923613Z","signature_b64":"RL1cZHZ8Wr1pf1+n/SNDGpQKuy2e5dmPFq7cCH7DILQk8LjCBkBBymd8jVJMmNrnACNweaIxxuc8J1fR2GMKAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4030d18470f1538480c6f8a8ca5f17429dc59be7d9077b30c93be517d6c49a35","last_reissued_at":"2026-05-18T01:17:36.922914Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:17:36.922914Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.05758","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:17:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JqS7P55oedEecjPl+tctwunhyCb+5z6gQHvZeWiLvJu3wjGuJghnXh8FaCPPBYOWdG5OpX7Cvki4sgdUiA3gAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T20:54:26.930160Z"},"content_sha256":"a0bdaf62bd5e42032bf6518f17c8796803de9c0019d8c32ece99ca58ff430beb","schema_version":"1.0","event_id":"sha256:a0bdaf62bd5e42032bf6518f17c8796803de9c0019d8c32ece99ca58ff430beb"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:IAYNDBDQ6FJYJAGG7CUMUXYXIK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Rhythmomimetic drug delivery: modeling, analysis and numerical simulation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft","q-bio.CB"],"primary_cat":"physics.chem-ph","authors_text":"Lingxing Yao, M. Carme Calderer, Ronald A. Siegel, Yoichiro Mori","submitted_at":"2015-01-06T16:15:51Z","abstract_excerpt":"We develop, analyse and numerically simulate a model of a prototype, glucose-driven, rhythmic drug delivery device, aimed at hormone therapies, and based on chemomechanical interaction in a polyelectrolyte gel membrane. The pH-driven interactions trigger volume phase transitions between the swollen and collapsed states of the gel.For a robust set of material parameters, we find a class of solutions of the governing system that oscillate between such states, and cause the membrane to rhythmically swell, allowing for transport of the drug, fuel and reaction products across it, and collapse, hamp"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.05758","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:17:36Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"EE3cGj4DErGI2Yh8DleHy+AF2ajiJGQYhhkaaabMlAF2xHknhSxT5tlqFE4c8H/UhlXBHMOv8vPRVA8NRNvmCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T20:54:26.930585Z"},"content_sha256":"f6daee8ebe6cd7e2562e140b99456f89e00e63fe63f86ef89c2bfe5a6fb1d4e7","schema_version":"1.0","event_id":"sha256:f6daee8ebe6cd7e2562e140b99456f89e00e63fe63f86ef89c2bfe5a6fb1d4e7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/bundle.json","state_url":"https://pith.science/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T20:54:26Z","links":{"resolver":"https://pith.science/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK","bundle":"https://pith.science/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/bundle.json","state":"https://pith.science/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/IAYNDBDQ6FJYJAGG7CUMUXYXIK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:IAYNDBDQ6FJYJAGG7CUMUXYXIK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"df662ce7a2f4f9a63103b646c1dcaa88e841e3020c8d84e84ac02768a1306a7d","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2015-01-06T16:15:51Z","title_canon_sha256":"6daa5ce2b27cc3c560b0b4711d711626d9bd6f5f8a55674ca2471e2a267b6183"},"schema_version":"1.0","source":{"id":"1512.05758","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.05758","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"arxiv_version","alias_value":"1512.05758v2","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.05758","created_at":"2026-05-18T01:17:36Z"},{"alias_kind":"pith_short_12","alias_value":"IAYNDBDQ6FJY","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_16","alias_value":"IAYNDBDQ6FJYJAGG","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_8","alias_value":"IAYNDBDQ","created_at":"2026-05-18T12:29:25Z"}],"graph_snapshots":[{"event_id":"sha256:f6daee8ebe6cd7e2562e140b99456f89e00e63fe63f86ef89c2bfe5a6fb1d4e7","target":"graph","created_at":"2026-05-18T01:17:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We develop, analyse and numerically simulate a model of a prototype, glucose-driven, rhythmic drug delivery device, aimed at hormone therapies, and based on chemomechanical interaction in a polyelectrolyte gel membrane. The pH-driven interactions trigger volume phase transitions between the swollen and collapsed states of the gel.For a robust set of material parameters, we find a class of solutions of the governing system that oscillate between such states, and cause the membrane to rhythmically swell, allowing for transport of the drug, fuel and reaction products across it, and collapse, hamp","authors_text":"Lingxing Yao, M. Carme Calderer, Ronald A. Siegel, Yoichiro Mori","cross_cats":["cond-mat.soft","q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2015-01-06T16:15:51Z","title":"Rhythmomimetic drug delivery: modeling, analysis and numerical simulation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.05758","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a0bdaf62bd5e42032bf6518f17c8796803de9c0019d8c32ece99ca58ff430beb","target":"record","created_at":"2026-05-18T01:17:36Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"df662ce7a2f4f9a63103b646c1dcaa88e841e3020c8d84e84ac02768a1306a7d","cross_cats_sorted":["cond-mat.soft","q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2015-01-06T16:15:51Z","title_canon_sha256":"6daa5ce2b27cc3c560b0b4711d711626d9bd6f5f8a55674ca2471e2a267b6183"},"schema_version":"1.0","source":{"id":"1512.05758","kind":"arxiv","version":2}},"canonical_sha256":"4030d18470f1538480c6f8a8ca5f17429dc59be7d9077b30c93be517d6c49a35","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4030d18470f1538480c6f8a8ca5f17429dc59be7d9077b30c93be517d6c49a35","first_computed_at":"2026-05-18T01:17:36.922914Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:17:36.922914Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"RL1cZHZ8Wr1pf1+n/SNDGpQKuy2e5dmPFq7cCH7DILQk8LjCBkBBymd8jVJMmNrnACNweaIxxuc8J1fR2GMKAg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:17:36.923613Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.05758","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a0bdaf62bd5e42032bf6518f17c8796803de9c0019d8c32ece99ca58ff430beb","sha256:f6daee8ebe6cd7e2562e140b99456f89e00e63fe63f86ef89c2bfe5a6fb1d4e7"],"state_sha256":"b2c90476545a7def0c607207a014aba48dc322c09b1c6965c87b175a7712acd7"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"JtQHk9nsPltTjWjj62W0zODC8w1TpON2vkYJrUNfeAkrp8rNT0IcJF1hwz0pKSo5msbKS2lFiUILPiX5eD8BCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T20:54:26.935189Z","bundle_sha256":"d9e13af411937b6e5cfb8eb443560ccc0ac3ab246a7da028bbd57acb6c79a813"}}