{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2013:ICEHRMOP3YBLNP7KZTZ42ABRIK","short_pith_number":"pith:ICEHRMOP","canonical_record":{"source":{"id":"1305.2249","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-10T02:36:26Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"724c6cee7d1ad4b9e9ef56660ab99b9079bb762f463daa1ec22c1956071200e0","abstract_canon_sha256":"2a5470d5a22c71ad941abda5d79335ec9a49945a55e68b0c5f8f36713587cc84"},"schema_version":"1.0"},"canonical_sha256":"408878b1cfde02b6bfeaccf3cd003142b45f4ff0a60336f22fae186ebd52d9c7","source":{"kind":"arxiv","id":"1305.2249","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1305.2249","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"arxiv_version","alias_value":"1305.2249v1","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1305.2249","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"pith_short_12","alias_value":"ICEHRMOP3YBL","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_16","alias_value":"ICEHRMOP3YBLNP7K","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_8","alias_value":"ICEHRMOP","created_at":"2026-05-18T12:27:46Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2013:ICEHRMOP3YBLNP7KZTZ42ABRIK","target":"record","payload":{"canonical_record":{"source":{"id":"1305.2249","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-10T02:36:26Z","cross_cats_sorted":["q-bio.PE"],"title_canon_sha256":"724c6cee7d1ad4b9e9ef56660ab99b9079bb762f463daa1ec22c1956071200e0","abstract_canon_sha256":"2a5470d5a22c71ad941abda5d79335ec9a49945a55e68b0c5f8f36713587cc84"},"schema_version":"1.0"},"canonical_sha256":"408878b1cfde02b6bfeaccf3cd003142b45f4ff0a60336f22fae186ebd52d9c7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:26:08.312591Z","signature_b64":"L5U/7lpggA0wuZI5W0xcYcuwZMAzgPA9AI4mWhsAd56g6eBDNbx0HSzDJG0qj4whug0aHn4PmRB8/3QsIgaeBA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"408878b1cfde02b6bfeaccf3cd003142b45f4ff0a60336f22fae186ebd52d9c7","last_reissued_at":"2026-05-18T03:26:08.311974Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:26:08.311974Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1305.2249","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:26:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"4P+Y0pjSohN019JULQzs19QAIDk+NVcZMnoEr+kdq+fdi7e3HRP90Dgrcz0RfwOzucPVnd2gdHp0BSWTHfCLDw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T05:57:48.971237Z"},"content_sha256":"c873e8cf6dfd8f2f1107140f3fe0b3edad7bc565935706b952e517de046b4fa9","schema_version":"1.0","event_id":"sha256:c873e8cf6dfd8f2f1107140f3fe0b3edad7bc565935706b952e517de046b4fa9"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2013:ICEHRMOP3YBLNP7KZTZ42ABRIK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Exploiting ecological principles to better understand cancer progression and treatment","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE"],"primary_cat":"q-bio.TO","authors_text":"Alexander R. A. Anderson, David Basanta","submitted_at":"2013-05-10T02:36:26Z","abstract_excerpt":"A small but growing number of people are finding interesting parallels between ecosystems as studied by ecologists (think of a Savanna or the Amazon rain forest or a Coral reef) and tumours1-3. The idea of viewing cancer from an ecological perspective has many implications but fundamentally, it means that we should not see cancer just as a group of mutated cells. A more useful definition of cancer is to consider it a disruption in the complex balance of many interacting cellular and microenvironmental elements in a specific organ. This perspective means that organs undergoing carcinogenesis sh"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1305.2249","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:26:08Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"iMWIilttUwmFc2F5SPhN2fiyv6A4R8B40+PNqWROdzeZ91aSNQ7c7qGv9jrL45L//nErOtOteLkxfHF62+GSAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-26T05:57:48.971930Z"},"content_sha256":"881b10dc94df71dd47faac289271af38b1b28e33b045d7f983215ecb18f4fe3f","schema_version":"1.0","event_id":"sha256:881b10dc94df71dd47faac289271af38b1b28e33b045d7f983215ecb18f4fe3f"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/bundle.json","state_url":"https://pith.science/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-26T05:57:48Z","links":{"resolver":"https://pith.science/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK","bundle":"https://pith.science/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/bundle.json","state":"https://pith.science/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ICEHRMOP3YBLNP7KZTZ42ABRIK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2013:ICEHRMOP3YBLNP7KZTZ42ABRIK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"2a5470d5a22c71ad941abda5d79335ec9a49945a55e68b0c5f8f36713587cc84","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-10T02:36:26Z","title_canon_sha256":"724c6cee7d1ad4b9e9ef56660ab99b9079bb762f463daa1ec22c1956071200e0"},"schema_version":"1.0","source":{"id":"1305.2249","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1305.2249","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"arxiv_version","alias_value":"1305.2249v1","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1305.2249","created_at":"2026-05-18T03:26:08Z"},{"alias_kind":"pith_short_12","alias_value":"ICEHRMOP3YBL","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_16","alias_value":"ICEHRMOP3YBLNP7K","created_at":"2026-05-18T12:27:46Z"},{"alias_kind":"pith_short_8","alias_value":"ICEHRMOP","created_at":"2026-05-18T12:27:46Z"}],"graph_snapshots":[{"event_id":"sha256:881b10dc94df71dd47faac289271af38b1b28e33b045d7f983215ecb18f4fe3f","target":"graph","created_at":"2026-05-18T03:26:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"A small but growing number of people are finding interesting parallels between ecosystems as studied by ecologists (think of a Savanna or the Amazon rain forest or a Coral reef) and tumours1-3. The idea of viewing cancer from an ecological perspective has many implications but fundamentally, it means that we should not see cancer just as a group of mutated cells. A more useful definition of cancer is to consider it a disruption in the complex balance of many interacting cellular and microenvironmental elements in a specific organ. This perspective means that organs undergoing carcinogenesis sh","authors_text":"Alexander R. A. Anderson, David Basanta","cross_cats":["q-bio.PE"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-10T02:36:26Z","title":"Exploiting ecological principles to better understand cancer progression and treatment"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1305.2249","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c873e8cf6dfd8f2f1107140f3fe0b3edad7bc565935706b952e517de046b4fa9","target":"record","created_at":"2026-05-18T03:26:08Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"2a5470d5a22c71ad941abda5d79335ec9a49945a55e68b0c5f8f36713587cc84","cross_cats_sorted":["q-bio.PE"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2013-05-10T02:36:26Z","title_canon_sha256":"724c6cee7d1ad4b9e9ef56660ab99b9079bb762f463daa1ec22c1956071200e0"},"schema_version":"1.0","source":{"id":"1305.2249","kind":"arxiv","version":1}},"canonical_sha256":"408878b1cfde02b6bfeaccf3cd003142b45f4ff0a60336f22fae186ebd52d9c7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"408878b1cfde02b6bfeaccf3cd003142b45f4ff0a60336f22fae186ebd52d9c7","first_computed_at":"2026-05-18T03:26:08.311974Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:26:08.311974Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"L5U/7lpggA0wuZI5W0xcYcuwZMAzgPA9AI4mWhsAd56g6eBDNbx0HSzDJG0qj4whug0aHn4PmRB8/3QsIgaeBA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:26:08.312591Z","signed_message":"canonical_sha256_bytes"},"source_id":"1305.2249","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c873e8cf6dfd8f2f1107140f3fe0b3edad7bc565935706b952e517de046b4fa9","sha256:881b10dc94df71dd47faac289271af38b1b28e33b045d7f983215ecb18f4fe3f"],"state_sha256":"4bc86846a08c416ee8c04f9327f273738e1c276b21c699f4432a257adf7d7ec9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+Q9XrM9RqDhUatv96fgllx/zx9CbZUtE5UWsyEHZDsI8YTzaZkBcyYEZKdLQXaSu4A0QMycxTQcnNwxxlOoFCQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-26T05:57:48.975336Z","bundle_sha256":"18d40fa199dfab6f5710f1df3af6be532b5fec301a44c351c238a520f7bdb17c"}}