{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2025:IFU4AT6WR5ZHLKFWCQ5MGW5LRU","short_pith_number":"pith:IFU4AT6W","canonical_record":{"source":{"id":"2505.02750","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2025-05-05T16:04:40Z","cross_cats_sorted":["q-bio.MN","stat.AP"],"title_canon_sha256":"6304200a54bb95a5d383aefe561d3663b5de924c5b45489ac1b3b676f549a8e7","abstract_canon_sha256":"d240df28911c62857e4c708e8cdcd57242fd4a192b887d9d0c37244bf6722a40"},"schema_version":"1.0"},"canonical_sha256":"4169c04fd68f7275a8b6143ac35bab8d226c91c8947f85ff58d6e5163a8c158f","source":{"kind":"arxiv","id":"2505.02750","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.02750","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"arxiv_version","alias_value":"2505.02750v3","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.02750","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_12","alias_value":"IFU4AT6WR5ZH","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_16","alias_value":"IFU4AT6WR5ZHLKFW","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_8","alias_value":"IFU4AT6W","created_at":"2026-07-05T11:17:45Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2025:IFU4AT6WR5ZHLKFWCQ5MGW5LRU","target":"record","payload":{"canonical_record":{"source":{"id":"2505.02750","kind":"arxiv","version":3},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2025-05-05T16:04:40Z","cross_cats_sorted":["q-bio.MN","stat.AP"],"title_canon_sha256":"6304200a54bb95a5d383aefe561d3663b5de924c5b45489ac1b3b676f549a8e7","abstract_canon_sha256":"d240df28911c62857e4c708e8cdcd57242fd4a192b887d9d0c37244bf6722a40"},"schema_version":"1.0"},"canonical_sha256":"4169c04fd68f7275a8b6143ac35bab8d226c91c8947f85ff58d6e5163a8c158f","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T11:17:45.153627Z","signature_b64":"VohdB8PRPFbKCvpzWe5gUxFwuGigaAofmlFK8agexyImc/b25Z+3az/jxln3xc9L7evU1wUbuAzl5rTXN8PgDA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4169c04fd68f7275a8b6143ac35bab8d226c91c8947f85ff58d6e5163a8c158f","last_reissued_at":"2026-07-05T11:17:45.153185Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T11:17:45.153185Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2505.02750","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:17:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BnP6bLScXIOsengKFnbdd9gAdE6eACV/M7g498l+v9IAau5q1YqH6Uj21soQcwaKthTzn5Saq9n55S9r0Ed8Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T14:07:11.595124Z"},"content_sha256":"eb07f82062f839c2dd5481405dfc11bc8f7301b07ac957a95a63441883526f4e","schema_version":"1.0","event_id":"sha256:eb07f82062f839c2dd5481405dfc11bc8f7301b07ac957a95a63441883526f4e"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2025:IFU4AT6WR5ZHLKFWCQ5MGW5LRU","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"A CRISP approach to QSP: XAI enabling fit-for-purpose models","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.MN","stat.AP"],"primary_cat":"q-bio.QM","authors_text":"Christian N. K. Anderson, Mark K. Transtrum, Noah DeTal","submitted_at":"2025-05-05T16:04:40Z","abstract_excerpt":"Quantitative Systems Pharmacology (QSP) promises to accelerate drug development, enable personalized medicine, and improve the predictability of clinical outcomes. Realizing this potential requires effectively managing the complexity of mathematical models representing biological systems. Here, we present and validate a novel QSP workflow--CRISP (Contextualized Reduction for Identifiability and Scientific Precision)--that addresses a central challenge in QSP: the problem of complexity and over-parameterization, in which models contain irrelevant parameters that obscure interpretation and hinde"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.02750","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2505.02750/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T11:17:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vE6tsdnaoGS94GLvu2sG5Nipyb6M1/QANFLVlVa5Y5/grQRQRUiT49zSIOrZcqYqBu8XyTBfylQOvfCs2+hQCQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-14T14:07:11.595635Z"},"content_sha256":"a22c1c6a8bb126b1cf43f95fdb40bef9a7538cf23a00ab33641e2ad298880e24","schema_version":"1.0","event_id":"sha256:a22c1c6a8bb126b1cf43f95fdb40bef9a7538cf23a00ab33641e2ad298880e24"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/bundle.json","state_url":"https://pith.science/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-14T14:07:11Z","links":{"resolver":"https://pith.science/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU","bundle":"https://pith.science/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/bundle.json","state":"https://pith.science/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/state.json","well_known_bundle":"https://pith.science/.well-known/pith/IFU4AT6WR5ZHLKFWCQ5MGW5LRU/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:IFU4AT6WR5ZHLKFWCQ5MGW5LRU","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d240df28911c62857e4c708e8cdcd57242fd4a192b887d9d0c37244bf6722a40","cross_cats_sorted":["q-bio.MN","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2025-05-05T16:04:40Z","title_canon_sha256":"6304200a54bb95a5d383aefe561d3663b5de924c5b45489ac1b3b676f549a8e7"},"schema_version":"1.0","source":{"id":"2505.02750","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2505.02750","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"arxiv_version","alias_value":"2505.02750v3","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2505.02750","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_12","alias_value":"IFU4AT6WR5ZH","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_16","alias_value":"IFU4AT6WR5ZHLKFW","created_at":"2026-07-05T11:17:45Z"},{"alias_kind":"pith_short_8","alias_value":"IFU4AT6W","created_at":"2026-07-05T11:17:45Z"}],"graph_snapshots":[{"event_id":"sha256:a22c1c6a8bb126b1cf43f95fdb40bef9a7538cf23a00ab33641e2ad298880e24","target":"graph","created_at":"2026-07-05T11:17:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2505.02750/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Quantitative Systems Pharmacology (QSP) promises to accelerate drug development, enable personalized medicine, and improve the predictability of clinical outcomes. Realizing this potential requires effectively managing the complexity of mathematical models representing biological systems. Here, we present and validate a novel QSP workflow--CRISP (Contextualized Reduction for Identifiability and Scientific Precision)--that addresses a central challenge in QSP: the problem of complexity and over-parameterization, in which models contain irrelevant parameters that obscure interpretation and hinde","authors_text":"Christian N. K. Anderson, Mark K. Transtrum, Noah DeTal","cross_cats":["q-bio.MN","stat.AP"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2025-05-05T16:04:40Z","title":"A CRISP approach to QSP: XAI enabling fit-for-purpose models"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2505.02750","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:eb07f82062f839c2dd5481405dfc11bc8f7301b07ac957a95a63441883526f4e","target":"record","created_at":"2026-07-05T11:17:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d240df28911c62857e4c708e8cdcd57242fd4a192b887d9d0c37244bf6722a40","cross_cats_sorted":["q-bio.MN","stat.AP"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.QM","submitted_at":"2025-05-05T16:04:40Z","title_canon_sha256":"6304200a54bb95a5d383aefe561d3663b5de924c5b45489ac1b3b676f549a8e7"},"schema_version":"1.0","source":{"id":"2505.02750","kind":"arxiv","version":3}},"canonical_sha256":"4169c04fd68f7275a8b6143ac35bab8d226c91c8947f85ff58d6e5163a8c158f","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4169c04fd68f7275a8b6143ac35bab8d226c91c8947f85ff58d6e5163a8c158f","first_computed_at":"2026-07-05T11:17:45.153185Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:17:45.153185Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VohdB8PRPFbKCvpzWe5gUxFwuGigaAofmlFK8agexyImc/b25Z+3az/jxln3xc9L7evU1wUbuAzl5rTXN8PgDA==","signature_status":"signed_v1","signed_at":"2026-07-05T11:17:45.153627Z","signed_message":"canonical_sha256_bytes"},"source_id":"2505.02750","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:eb07f82062f839c2dd5481405dfc11bc8f7301b07ac957a95a63441883526f4e","sha256:a22c1c6a8bb126b1cf43f95fdb40bef9a7538cf23a00ab33641e2ad298880e24"],"state_sha256":"d6fc8de2028fb6b24b145b9a55693612c8a93a86e565ac447394aa4f2dba2d99"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"19KW5W4jF+mJZrxi1zD1kIVcVnrBIilt/ll/SJhZdvYMe4uJ5Zz5UBkwkkgu/RdOcJwpPfh83do+SImW/X9YAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-14T14:07:11.599889Z","bundle_sha256":"38d56d0af990eda0fb052064caeaa6706314d778d4b0b44a7cdc2ed09ebcfd46"}}