{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:ILCVC2WG3PQ2WZCO3CYTOVD5ZH","short_pith_number":"pith:ILCVC2WG","canonical_record":{"source":{"id":"1903.10968","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-26T15:52:25Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"ae6252c56a465205b98d9908753ad7a8bfb0696817acb8bcc1d6aafafdde60ff","abstract_canon_sha256":"6da0b585c8dfeedee644a7e716222269436cd18fc6d2d9b5fc9a0705e69d22bd"},"schema_version":"1.0"},"canonical_sha256":"42c5516ac6dbe1ab644ed8b137547dc9f5e9b085ec9506943095f9856c434b13","source":{"kind":"arxiv","id":"1903.10968","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.10968","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"arxiv_version","alias_value":"1903.10968v1","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.10968","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"pith_short_12","alias_value":"ILCVC2WG3PQ2","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"ILCVC2WG3PQ2WZCO","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"ILCVC2WG","created_at":"2026-05-18T12:33:18Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:ILCVC2WG3PQ2WZCO3CYTOVD5ZH","target":"record","payload":{"canonical_record":{"source":{"id":"1903.10968","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-26T15:52:25Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"ae6252c56a465205b98d9908753ad7a8bfb0696817acb8bcc1d6aafafdde60ff","abstract_canon_sha256":"6da0b585c8dfeedee644a7e716222269436cd18fc6d2d9b5fc9a0705e69d22bd"},"schema_version":"1.0"},"canonical_sha256":"42c5516ac6dbe1ab644ed8b137547dc9f5e9b085ec9506943095f9856c434b13","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:50:17.107678Z","signature_b64":"cVYMUD8jIf279eHIkOiqSYAC/36EhthQwPdiuQpM9J4OIBPewOd0jB0XbykF2arPNkmg+JC3HnoeGv4Ym+wZAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"42c5516ac6dbe1ab644ed8b137547dc9f5e9b085ec9506943095f9856c434b13","last_reissued_at":"2026-05-17T23:50:17.106901Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:50:17.106901Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1903.10968","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:50:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"10nwrzeMNX9516bZGO29YyORPnZMuOxANkB7xowj9wVcu/6lA2tU3K9SjDG7GbwNpwK0uWWFV6XrLEsN5w76Cw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T18:19:12.753886Z"},"content_sha256":"046c2154fedf891623bc7b66010c916a9d8d4fb82a94fdaa73c22bc97955df6b","schema_version":"1.0","event_id":"sha256:046c2154fedf891623bc7b66010c916a9d8d4fb82a94fdaa73c22bc97955df6b"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:ILCVC2WG3PQ2WZCO3CYTOVD5ZH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"q-bio.MN","authors_text":"Brian J. Holleran, David St-Pierre, \\'Elie Besserer-Offroy, Emanuel Escher, Ga\\'etan Guillemette, J\\'er\\^ome Cabana, Pierre Lavigne, Richard Leduc","submitted_at":"2019-03-26T15:52:25Z","abstract_excerpt":"G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be significantly investigated. However, an important but often overlooked aspect of functional selectivity is the capability of ligands such as angiotensin II (AngII) to adopt specific conformations that may preferentially bind to selective GPCRs structures. U"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.10968","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:50:17Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"s9w1w3VXXlJuP7JF81245Cep41VMuoR0b3vekSvr++Js1lS0icesDaRvt1mVjlsJ2anNmCqD0V+FIaRa0C91Ag==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T18:19:12.754286Z"},"content_sha256":"a60175289fe76dd58a33443afd9b7ce3db80cf95d479a07856dfe89b3237e478","schema_version":"1.0","event_id":"sha256:a60175289fe76dd58a33443afd9b7ce3db80cf95d479a07856dfe89b3237e478"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/bundle.json","state_url":"https://pith.science/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T18:19:12Z","links":{"resolver":"https://pith.science/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH","bundle":"https://pith.science/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/bundle.json","state":"https://pith.science/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ILCVC2WG3PQ2WZCO3CYTOVD5ZH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:ILCVC2WG3PQ2WZCO3CYTOVD5ZH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6da0b585c8dfeedee644a7e716222269436cd18fc6d2d9b5fc9a0705e69d22bd","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-26T15:52:25Z","title_canon_sha256":"ae6252c56a465205b98d9908753ad7a8bfb0696817acb8bcc1d6aafafdde60ff"},"schema_version":"1.0","source":{"id":"1903.10968","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1903.10968","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"arxiv_version","alias_value":"1903.10968v1","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1903.10968","created_at":"2026-05-17T23:50:17Z"},{"alias_kind":"pith_short_12","alias_value":"ILCVC2WG3PQ2","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_16","alias_value":"ILCVC2WG3PQ2WZCO","created_at":"2026-05-18T12:33:18Z"},{"alias_kind":"pith_short_8","alias_value":"ILCVC2WG","created_at":"2026-05-18T12:33:18Z"}],"graph_snapshots":[{"event_id":"sha256:a60175289fe76dd58a33443afd9b7ce3db80cf95d479a07856dfe89b3237e478","target":"graph","created_at":"2026-05-17T23:50:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"G protein coupled receptors (GPCRs) produce pleiotropic effects by their capacity to engage numerous signaling pathways once activated. Functional selectivity (also called biased signaling), where specific compounds can bring GPCRs to adopt conformations that enable selective receptor coupling to distinct signaling pathways, continues to be significantly investigated. However, an important but often overlooked aspect of functional selectivity is the capability of ligands such as angiotensin II (AngII) to adopt specific conformations that may preferentially bind to selective GPCRs structures. U","authors_text":"Brian J. Holleran, David St-Pierre, \\'Elie Besserer-Offroy, Emanuel Escher, Ga\\'etan Guillemette, J\\'er\\^ome Cabana, Pierre Lavigne, Richard Leduc","cross_cats":["q-bio.BM"],"headline":"","license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-26T15:52:25Z","title":"Angiotensin II cyclic analogs as tools to investigate AT1R biased signaling mechanisms"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1903.10968","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:046c2154fedf891623bc7b66010c916a9d8d4fb82a94fdaa73c22bc97955df6b","target":"record","created_at":"2026-05-17T23:50:17Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6da0b585c8dfeedee644a7e716222269436cd18fc6d2d9b5fc9a0705e69d22bd","cross_cats_sorted":["q-bio.BM"],"license":"http://creativecommons.org/licenses/by-nc-sa/4.0/","primary_cat":"q-bio.MN","submitted_at":"2019-03-26T15:52:25Z","title_canon_sha256":"ae6252c56a465205b98d9908753ad7a8bfb0696817acb8bcc1d6aafafdde60ff"},"schema_version":"1.0","source":{"id":"1903.10968","kind":"arxiv","version":1}},"canonical_sha256":"42c5516ac6dbe1ab644ed8b137547dc9f5e9b085ec9506943095f9856c434b13","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"42c5516ac6dbe1ab644ed8b137547dc9f5e9b085ec9506943095f9856c434b13","first_computed_at":"2026-05-17T23:50:17.106901Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:50:17.106901Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"cVYMUD8jIf279eHIkOiqSYAC/36EhthQwPdiuQpM9J4OIBPewOd0jB0XbykF2arPNkmg+JC3HnoeGv4Ym+wZAA==","signature_status":"signed_v1","signed_at":"2026-05-17T23:50:17.107678Z","signed_message":"canonical_sha256_bytes"},"source_id":"1903.10968","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:046c2154fedf891623bc7b66010c916a9d8d4fb82a94fdaa73c22bc97955df6b","sha256:a60175289fe76dd58a33443afd9b7ce3db80cf95d479a07856dfe89b3237e478"],"state_sha256":"d441b6b43b004d17670fda98ee1348c167b2d1abf58abdd695696fe26467d333"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"NsSBfTqdSybfbEPu/cnEFVQPgvY7Rt0rz2/biO4rEysKCxz4yThBHEpzXK5JgCkWEdEtOiuoqCrgl8cSIqzBDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T18:19:12.757520Z","bundle_sha256":"fcb20b720e7edf3fcad6bc830f6ac068280cad5863cffb6efee617fcb34a13f5"}}