{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:ILDPMV5SCONVELXTEONFLJTSCK","short_pith_number":"pith:ILDPMV5S","canonical_record":{"source":{"id":"1908.08135","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-08-21T22:51:29Z","cross_cats_sorted":[],"title_canon_sha256":"2fa2319eea5c4a80c5b6d1de99c0ea548db6ca7674179d32556516c97bda26e6","abstract_canon_sha256":"eb48930d498c432d129c88101920423cac1fc0ace60ae4859fec440dad9b3a6f"},"schema_version":"1.0"},"canonical_sha256":"42c6f657b2139b522ef3239a55a672129180afae2a08dc76062c2027bc8f6025","source":{"kind":"arxiv","id":"1908.08135","version":4},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.08135","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"arxiv_version","alias_value":"1908.08135v4","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.08135","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_12","alias_value":"ILDPMV5SCONV","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_16","alias_value":"ILDPMV5SCONVELXT","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_8","alias_value":"ILDPMV5S","created_at":"2026-07-05T00:58:04Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:ILDPMV5SCONVELXTEONFLJTSCK","target":"record","payload":{"canonical_record":{"source":{"id":"1908.08135","kind":"arxiv","version":4},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-08-21T22:51:29Z","cross_cats_sorted":[],"title_canon_sha256":"2fa2319eea5c4a80c5b6d1de99c0ea548db6ca7674179d32556516c97bda26e6","abstract_canon_sha256":"eb48930d498c432d129c88101920423cac1fc0ace60ae4859fec440dad9b3a6f"},"schema_version":"1.0"},"canonical_sha256":"42c6f657b2139b522ef3239a55a672129180afae2a08dc76062c2027bc8f6025","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T00:58:04.355098Z","signature_b64":"oiocnw7b77Dw6g+hkaQkB/L+cjpt8YHyk3GwB+PTnb8FMorjjzKl4P8QbQ4WFGteMRjxkDS+tMbDGK2JNc2RAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"42c6f657b2139b522ef3239a55a672129180afae2a08dc76062c2027bc8f6025","last_reissued_at":"2026-07-05T00:58:04.354675Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T00:58:04.354675Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1908.08135","source_version":4,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:58:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"t91Zr03rYxKSffRI0BH+JX03SaNlI8qPk+iSLtJZkXunGrgK0JaHs4xwo6PcCg1c2FChJu+2FIRO43n+voj0DQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T15:50:39.322812Z"},"content_sha256":"9d8f0fd10a6452f73a5fd7c1b24a8a7db2a0b8882e9954a651bea5ba2b27c32c","schema_version":"1.0","event_id":"sha256:9d8f0fd10a6452f73a5fd7c1b24a8a7db2a0b8882e9954a651bea5ba2b27c32c"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:ILDPMV5SCONVELXTEONFLJTSCK","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Supervised prediction of aging-related genes from a context-specific protein interaction subnetwork","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"Qi Li, Tijana Milenkovi\\'c","submitted_at":"2019-08-21T22:51:29Z","abstract_excerpt":"Background. Human aging is linked to many prevalent diseases. The aging process is highly influenced by genetic factors. Hence, it is important to identify human aging-related genes. We focus on supervised prediction of such genes. Gene expression-based methods for this purpose study genes in isolation from each other. While protein-protein interaction (PPI) network-based methods for this purpose account for interactions between genes' protein products, current PPI network data are context-unspecific, spanning different biological conditions. Instead, here, we focus on an aging-specific subnet"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.08135","kind":"arxiv","version":4},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1908.08135/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:58:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"9kszzZr0Isiu3kwgftXyKLSOK3j4iNCitIzOWe/Du5RyPrYGaUR91Y/fHVtTa8J4QgX5DMlaO02qf6lOsSbvBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-16T15:50:39.323330Z"},"content_sha256":"3ac1a5ec6771189c239db1118af5d08d2d8cdecaacac34c267617c0d6780c9df","schema_version":"1.0","event_id":"sha256:3ac1a5ec6771189c239db1118af5d08d2d8cdecaacac34c267617c0d6780c9df"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/ILDPMV5SCONVELXTEONFLJTSCK/bundle.json","state_url":"https://pith.science/pith/ILDPMV5SCONVELXTEONFLJTSCK/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/ILDPMV5SCONVELXTEONFLJTSCK/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-16T15:50:39Z","links":{"resolver":"https://pith.science/pith/ILDPMV5SCONVELXTEONFLJTSCK","bundle":"https://pith.science/pith/ILDPMV5SCONVELXTEONFLJTSCK/bundle.json","state":"https://pith.science/pith/ILDPMV5SCONVELXTEONFLJTSCK/state.json","well_known_bundle":"https://pith.science/.well-known/pith/ILDPMV5SCONVELXTEONFLJTSCK/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:ILDPMV5SCONVELXTEONFLJTSCK","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"eb48930d498c432d129c88101920423cac1fc0ace60ae4859fec440dad9b3a6f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-08-21T22:51:29Z","title_canon_sha256":"2fa2319eea5c4a80c5b6d1de99c0ea548db6ca7674179d32556516c97bda26e6"},"schema_version":"1.0","source":{"id":"1908.08135","kind":"arxiv","version":4}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1908.08135","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"arxiv_version","alias_value":"1908.08135v4","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1908.08135","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_12","alias_value":"ILDPMV5SCONV","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_16","alias_value":"ILDPMV5SCONVELXT","created_at":"2026-07-05T00:58:04Z"},{"alias_kind":"pith_short_8","alias_value":"ILDPMV5S","created_at":"2026-07-05T00:58:04Z"}],"graph_snapshots":[{"event_id":"sha256:3ac1a5ec6771189c239db1118af5d08d2d8cdecaacac34c267617c0d6780c9df","target":"graph","created_at":"2026-07-05T00:58:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1908.08135/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Background. Human aging is linked to many prevalent diseases. The aging process is highly influenced by genetic factors. Hence, it is important to identify human aging-related genes. We focus on supervised prediction of such genes. Gene expression-based methods for this purpose study genes in isolation from each other. While protein-protein interaction (PPI) network-based methods for this purpose account for interactions between genes' protein products, current PPI network data are context-unspecific, spanning different biological conditions. Instead, here, we focus on an aging-specific subnet","authors_text":"Qi Li, Tijana Milenkovi\\'c","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-08-21T22:51:29Z","title":"Supervised prediction of aging-related genes from a context-specific protein interaction subnetwork"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1908.08135","kind":"arxiv","version":4},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:9d8f0fd10a6452f73a5fd7c1b24a8a7db2a0b8882e9954a651bea5ba2b27c32c","target":"record","created_at":"2026-07-05T00:58:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"eb48930d498c432d129c88101920423cac1fc0ace60ae4859fec440dad9b3a6f","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2019-08-21T22:51:29Z","title_canon_sha256":"2fa2319eea5c4a80c5b6d1de99c0ea548db6ca7674179d32556516c97bda26e6"},"schema_version":"1.0","source":{"id":"1908.08135","kind":"arxiv","version":4}},"canonical_sha256":"42c6f657b2139b522ef3239a55a672129180afae2a08dc76062c2027bc8f6025","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"42c6f657b2139b522ef3239a55a672129180afae2a08dc76062c2027bc8f6025","first_computed_at":"2026-07-05T00:58:04.354675Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T00:58:04.354675Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oiocnw7b77Dw6g+hkaQkB/L+cjpt8YHyk3GwB+PTnb8FMorjjzKl4P8QbQ4WFGteMRjxkDS+tMbDGK2JNc2RAw==","signature_status":"signed_v1","signed_at":"2026-07-05T00:58:04.355098Z","signed_message":"canonical_sha256_bytes"},"source_id":"1908.08135","source_kind":"arxiv","source_version":4}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:9d8f0fd10a6452f73a5fd7c1b24a8a7db2a0b8882e9954a651bea5ba2b27c32c","sha256:3ac1a5ec6771189c239db1118af5d08d2d8cdecaacac34c267617c0d6780c9df"],"state_sha256":"97678277cd8428bf5fd17f188b2a1e7af0fa831836b5c06000955b615378c04f"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xtpZv/nHI4T2aLQ6J2sh8eeXlUk+5MQowkXdJJeJo0Adxm9Rpyij+8bw4KwOr9X19e200vl7JVuzPm6k/ZDKBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-16T15:50:39.327331Z","bundle_sha256":"2a0066de527ba29bc5a3ac46b30b739a2772b38376d4cf2764498540d22d8782"}}