{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:INJGZWUG4MNEJ65CQE646G3MC5","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6c57b917da80c9e225096e96faba9315584caf4ecffcddaff70352f8d141e1ed","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-28T02:21:40Z","title_canon_sha256":"bf955766fdc391342a44dbf525ee72b411586a30ce5bae6b9510116cd57ad7e0"},"schema_version":"1.0","source":{"id":"1512.08305","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.08305","created_at":"2026-05-18T01:10:55Z"},{"alias_kind":"arxiv_version","alias_value":"1512.08305v1","created_at":"2026-05-18T01:10:55Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.08305","created_at":"2026-05-18T01:10:55Z"},{"alias_kind":"pith_short_12","alias_value":"INJGZWUG4MNE","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_16","alias_value":"INJGZWUG4MNEJ65C","created_at":"2026-05-18T12:29:25Z"},{"alias_kind":"pith_short_8","alias_value":"INJGZWUG","created_at":"2026-05-18T12:29:25Z"}],"graph_snapshots":[{"event_id":"sha256:f9cc0bff41b8a4f6183a812a2d9c193ac3b327778e2719806e92e744de36d102","target":"graph","created_at":"2026-05-18T01:10:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Pancreatic islets are functional units involved in glucose homeostasis. The multicellular system comprises three main cell types; $\\beta$ and $\\alpha$ cells reciprocally decrease and increase blood glucose by producing insulin and glucagon pulses, while the role of $\\delta$ cells is less clear. Although their spatial organization and the paracrine/autocrine interactions between them have been extensively studied, the functional implications of the design principles are still lacking. In this study, we formulated a mathematical model that integrates the pulsatility of hormone secretion and the ","authors_text":"Danh-Tai Hoang, Junghyo Jo, Manami Hara","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-28T02:21:40Z","title":"Design Principles of Pancreatic Islets: Glucose-dependent Coordination of Hormone Pulses"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.08305","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ac49fbdcb33ae232e385fb2d5423422befdbf74d030fb141a6154b0867f0cd22","target":"record","created_at":"2026-05-18T01:10:55Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6c57b917da80c9e225096e96faba9315584caf4ecffcddaff70352f8d141e1ed","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2015-12-28T02:21:40Z","title_canon_sha256":"bf955766fdc391342a44dbf525ee72b411586a30ce5bae6b9510116cd57ad7e0"},"schema_version":"1.0","source":{"id":"1512.08305","kind":"arxiv","version":1}},"canonical_sha256":"43526cda86e31a44fba2813dcf1b6c17618bce6cab1a2086236fed63c5114d81","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"43526cda86e31a44fba2813dcf1b6c17618bce6cab1a2086236fed63c5114d81","first_computed_at":"2026-05-18T01:10:55.433561Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:10:55.433561Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"VIo4iz1Sb+r3uK12NaHcqLTbAJrrNZjIVxKZqe8+6Tcm8bEf/nc9ee42xMwUrZeRPXe/9fp8CpYSxosgWhpPAQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:10:55.434022Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.08305","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ac49fbdcb33ae232e385fb2d5423422befdbf74d030fb141a6154b0867f0cd22","sha256:f9cc0bff41b8a4f6183a812a2d9c193ac3b327778e2719806e92e744de36d102"],"state_sha256":"4675dd883b3f6c015315daca9173878ae0bf6656eb614a5efb489ca1b53dd42a"}