{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:IOARMXLGG67CILC3SHUQJI5WG4","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6e152237dcbd1711e88645e20f388f95f9409ad6afc6b6540849d87594c0f3e7","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-16T15:35:31Z","title_canon_sha256":"758e7ed7b898249dd314241850219769b84799de7bcb92f00c2b642f1e90c78e"},"schema_version":"1.0","source":{"id":"2606.18058","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.18058","created_at":"2026-06-19T16:10:47Z"},{"alias_kind":"arxiv_version","alias_value":"2606.18058v1","created_at":"2026-06-19T16:10:47Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.18058","created_at":"2026-06-19T16:10:47Z"},{"alias_kind":"pith_short_12","alias_value":"IOARMXLGG67C","created_at":"2026-06-19T16:10:47Z"},{"alias_kind":"pith_short_16","alias_value":"IOARMXLGG67CILC3","created_at":"2026-06-19T16:10:47Z"},{"alias_kind":"pith_short_8","alias_value":"IOARMXLG","created_at":"2026-06-19T16:10:47Z"}],"graph_snapshots":[{"event_id":"sha256:ab914da98989f2fc328ecab52bb196deed4fed9b95d47e44190a9e2c0d3a85a3","target":"graph","created_at":"2026-06-19T16:10:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.18058/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"We present a novel multiscale algorithm for directly recovering the atomic model structure of a protein from single-particle cryo-EM data. Our algorithm is able to estimate protein structures to state-of-the-art accuracy for high-noise and low-contrast data. It is also robust to misspecifications in the TEM image formation model. These desirable properties are primarily due to the use of an explicit representation of the protein backbone in terms of bonds, torsion angles and bond angles, which supplies rich prior information to the structure recovery process. We apply our method on three prote","authors_text":"David Y. W. Thong, Joakim And\\'en, Ozan \\\"Oktem","cross_cats":["q-bio.QM"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-16T15:35:31Z","title":"Multiscale reconstruction of protein conformations from cryo-EM images"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.18058","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e76a51b6e01b055fefe6c9fa777b4765b06396488457da9e41b8d4fb2f5482f5","target":"record","created_at":"2026-06-19T16:10:47Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6e152237dcbd1711e88645e20f388f95f9409ad6afc6b6540849d87594c0f3e7","cross_cats_sorted":["q-bio.QM"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"eess.IV","submitted_at":"2026-06-16T15:35:31Z","title_canon_sha256":"758e7ed7b898249dd314241850219769b84799de7bcb92f00c2b642f1e90c78e"},"schema_version":"1.0","source":{"id":"2606.18058","kind":"arxiv","version":1}},"canonical_sha256":"4381165d6637be242c5b91e904a3b637253d2d899ab789c49de351bfe69097f7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4381165d6637be242c5b91e904a3b637253d2d899ab789c49de351bfe69097f7","first_computed_at":"2026-06-19T16:10:47.398375Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-19T16:10:47.398375Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+BrzYwlbPQdKOHF9ULXPMen3/vM7/qnj29ASv7SVo129fOagTZI6vNaJEagakoejc+1Xea3PZFn5zRBj3AixCQ==","signature_status":"signed_v1","signed_at":"2026-06-19T16:10:47.398740Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.18058","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e76a51b6e01b055fefe6c9fa777b4765b06396488457da9e41b8d4fb2f5482f5","sha256:ab914da98989f2fc328ecab52bb196deed4fed9b95d47e44190a9e2c0d3a85a3"],"state_sha256":"b5acf1e6956cb978787eaf2f7c6ba2c04a8de1a4d811dfa15ea790c7dac89cd8"}