{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2026:IODDUNZYFY5KC77EWJCMTB6JYC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"a46a9486dd74dfca53a26c490ba84a80789e65d1d6ecb29ab42e11c653ec2e85","cross_cats_sorted":["cs.AI","cs.CE"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-05-25T19:53:02Z","title_canon_sha256":"32e0d27558cb3aa4532830922fee170e05ba5c081df7233f45a43bbcf0e71aa8"},"schema_version":"1.0","source":{"id":"2606.07567","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2606.07567","created_at":"2026-06-09T00:04:43Z"},{"alias_kind":"arxiv_version","alias_value":"2606.07567v1","created_at":"2026-06-09T00:04:43Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2606.07567","created_at":"2026-06-09T00:04:43Z"},{"alias_kind":"pith_short_12","alias_value":"IODDUNZYFY5K","created_at":"2026-06-09T00:04:43Z"},{"alias_kind":"pith_short_16","alias_value":"IODDUNZYFY5KC77E","created_at":"2026-06-09T00:04:43Z"},{"alias_kind":"pith_short_8","alias_value":"IODDUNZY","created_at":"2026-06-09T00:04:43Z"}],"graph_snapshots":[{"event_id":"sha256:77a594622775b1aa6834d346b1f0086a6c348d66ae592bd963d2741654cf22ee","target":"graph","created_at":"2026-06-09T00:04:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2606.07567/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Protein function is largely determined by molecular surface geometry and physicochemical complementarity, yet most protein design methods condition only on backbone structure. We introduce SurfDesign, a surface-conditioned protein design framework that models molecular surfaces as continuous geometric manifolds and integrates them with pretrained protein language models. SurfDesign employs surface-based equivariant message passing to capture surface normals, curvature, and directional geometry, together with a parameter-efficient fine-tuning strategy. Focusing on functional protein design, we ","authors_text":"Fang Wu, Jinbo Xu, Jure Leskovec, Mark Gerstein, Shuting Jin, Xiangru Tang, Xiangxiang Zeng, Yejin Choi","cross_cats":["cs.AI","cs.CE"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-05-25T19:53:02Z","title":"SurfDesign: Effective Protein Design on Molecular Surfaces"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2606.07567","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b2f1e1c88ea393ae0653867fbb5fabfcde8b8eb9d8d43d1d6d4d03863d93a0cb","target":"record","created_at":"2026-06-09T00:04:43Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"a46a9486dd74dfca53a26c490ba84a80789e65d1d6ecb29ab42e11c653ec2e85","cross_cats_sorted":["cs.AI","cs.CE"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2026-05-25T19:53:02Z","title_canon_sha256":"32e0d27558cb3aa4532830922fee170e05ba5c081df7233f45a43bbcf0e71aa8"},"schema_version":"1.0","source":{"id":"2606.07567","kind":"arxiv","version":1}},"canonical_sha256":"43863a37382e3aa17fe4b244c987c9c0900253d14174e80c96b08165638c5580","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"43863a37382e3aa17fe4b244c987c9c0900253d14174e80c96b08165638c5580","first_computed_at":"2026-06-09T00:04:43.191278Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-06-09T00:04:43.191278Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"uh7A5r0gghbPlCCu2lqwiYUABhu9MKyYG502pDIZ8Vlw4c0+PO2HccN4IfExsS1avA8lgzqFMjXcnWcGUGh+Cw==","signature_status":"signed_v1","signed_at":"2026-06-09T00:04:43.191937Z","signed_message":"canonical_sha256_bytes"},"source_id":"2606.07567","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b2f1e1c88ea393ae0653867fbb5fabfcde8b8eb9d8d43d1d6d4d03863d93a0cb","sha256:77a594622775b1aa6834d346b1f0086a6c348d66ae592bd963d2741654cf22ee"],"state_sha256":"ae7a48a6228bac47441574a3d975bc23d1b7d7efcf7779d69600ac54f2bb5cf7"}