{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:IQ5ITEMYEBOXC5K2VLPXXYMDOV","short_pith_number":"pith:IQ5ITEMY","canonical_record":{"source":{"id":"0912.3952","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2009-12-20T01:37:54Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"2a4da681cc1fb6ded82b9bc53547b3392432fcc385e2dafb3f9ccaaadffff9e5","abstract_canon_sha256":"80a1e4d8b925555bf72a73df98b507a884c40c38b5bbd5563f4d89b15cf02d0f"},"schema_version":"1.0"},"canonical_sha256":"443a899198205d71755aaadf7be1837547165098fcdb5e8986de6e0cf64e761e","source":{"kind":"arxiv","id":"0912.3952","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0912.3952","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"arxiv_version","alias_value":"0912.3952v3","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0912.3952","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"pith_short_12","alias_value":"IQ5ITEMYEBOX","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_16","alias_value":"IQ5ITEMYEBOXC5K2","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_8","alias_value":"IQ5ITEMY","created_at":"2026-05-18T12:26:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:IQ5ITEMYEBOXC5K2VLPXXYMDOV","target":"record","payload":{"canonical_record":{"source":{"id":"0912.3952","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2009-12-20T01:37:54Z","cross_cats_sorted":["cond-mat.soft"],"title_canon_sha256":"2a4da681cc1fb6ded82b9bc53547b3392432fcc385e2dafb3f9ccaaadffff9e5","abstract_canon_sha256":"80a1e4d8b925555bf72a73df98b507a884c40c38b5bbd5563f4d89b15cf02d0f"},"schema_version":"1.0"},"canonical_sha256":"443a899198205d71755aaadf7be1837547165098fcdb5e8986de6e0cf64e761e","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:24:45.370833Z","signature_b64":"DV+fFpMFr1vXwozi9B9HjteRTZt9txuBbzEiYhdydZGxaanfwTUspQ5QRqG7peZqDXFGCw/v2bK07tGM0gNaDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"443a899198205d71755aaadf7be1837547165098fcdb5e8986de6e0cf64e761e","last_reissued_at":"2026-05-18T04:24:45.370170Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:24:45.370170Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0912.3952","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:24:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"GTqTP8sqEptH0YQzNIkcRtPi024sFM+1EYRn0MjAbCfLDRv3akPhMrL96JKA6krQr5VsYZ7aNxkBw/D+0o9oBA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T00:20:31.353111Z"},"content_sha256":"ed2380d7ac2c6d7656bafaef6c39786d23e1943cd48cc4dbefc4c0106867a333","schema_version":"1.0","event_id":"sha256:ed2380d7ac2c6d7656bafaef6c39786d23e1943cd48cc4dbefc4c0106867a333"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:IQ5ITEMYEBOXC5K2VLPXXYMDOV","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Making it possible: constructing a reliable mechanism from a finite trajectory","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft"],"primary_cat":"q-bio.QM","authors_text":"Ophir Flomenbom","submitted_at":"2009-12-20T01:37:54Z","abstract_excerpt":"Deducing an underlying multi-substate on-off kinetic scheme (KS) from the statistical properties of a two-state trajectory is the aim from many experiments in biophysics and chemistry, such as, ion channel recordings, enzymatic activity and structural dynamics of bio-molecules. Doing so is almost always impossible, as the mapping of a KS into a two-state trajectory leads to the loss of information about the KS (almost always). Here, we present the optimal way to solve this problem. It is based on unique forms of reduced dimensions (RD). RD forms are on-off networks with connections only betwee"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0912.3952","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:24:45Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QZ1jYMFKB4BPNdzD8DF2fmClpZeAIx2m1Sb+Rj28c9w6xbAFy5Z4rsAM0SyTXSmMqd35drgEtKadfdzGPuZDAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T00:20:31.353717Z"},"content_sha256":"f6983d7e93524bca865d6275bae9c5279544fc149ae5fcc47efaf5a0579e6676","schema_version":"1.0","event_id":"sha256:f6983d7e93524bca865d6275bae9c5279544fc149ae5fcc47efaf5a0579e6676"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/bundle.json","state_url":"https://pith.science/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T00:20:31Z","links":{"resolver":"https://pith.science/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV","bundle":"https://pith.science/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/bundle.json","state":"https://pith.science/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/state.json","well_known_bundle":"https://pith.science/.well-known/pith/IQ5ITEMYEBOXC5K2VLPXXYMDOV/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:IQ5ITEMYEBOXC5K2VLPXXYMDOV","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"80a1e4d8b925555bf72a73df98b507a884c40c38b5bbd5563f4d89b15cf02d0f","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2009-12-20T01:37:54Z","title_canon_sha256":"2a4da681cc1fb6ded82b9bc53547b3392432fcc385e2dafb3f9ccaaadffff9e5"},"schema_version":"1.0","source":{"id":"0912.3952","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0912.3952","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"arxiv_version","alias_value":"0912.3952v3","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0912.3952","created_at":"2026-05-18T04:24:45Z"},{"alias_kind":"pith_short_12","alias_value":"IQ5ITEMYEBOX","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_16","alias_value":"IQ5ITEMYEBOXC5K2","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_8","alias_value":"IQ5ITEMY","created_at":"2026-05-18T12:26:00Z"}],"graph_snapshots":[{"event_id":"sha256:f6983d7e93524bca865d6275bae9c5279544fc149ae5fcc47efaf5a0579e6676","target":"graph","created_at":"2026-05-18T04:24:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Deducing an underlying multi-substate on-off kinetic scheme (KS) from the statistical properties of a two-state trajectory is the aim from many experiments in biophysics and chemistry, such as, ion channel recordings, enzymatic activity and structural dynamics of bio-molecules. Doing so is almost always impossible, as the mapping of a KS into a two-state trajectory leads to the loss of information about the KS (almost always). Here, we present the optimal way to solve this problem. It is based on unique forms of reduced dimensions (RD). RD forms are on-off networks with connections only betwee","authors_text":"Ophir Flomenbom","cross_cats":["cond-mat.soft"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2009-12-20T01:37:54Z","title":"Making it possible: constructing a reliable mechanism from a finite trajectory"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0912.3952","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ed2380d7ac2c6d7656bafaef6c39786d23e1943cd48cc4dbefc4c0106867a333","target":"record","created_at":"2026-05-18T04:24:45Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"80a1e4d8b925555bf72a73df98b507a884c40c38b5bbd5563f4d89b15cf02d0f","cross_cats_sorted":["cond-mat.soft"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2009-12-20T01:37:54Z","title_canon_sha256":"2a4da681cc1fb6ded82b9bc53547b3392432fcc385e2dafb3f9ccaaadffff9e5"},"schema_version":"1.0","source":{"id":"0912.3952","kind":"arxiv","version":3}},"canonical_sha256":"443a899198205d71755aaadf7be1837547165098fcdb5e8986de6e0cf64e761e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"443a899198205d71755aaadf7be1837547165098fcdb5e8986de6e0cf64e761e","first_computed_at":"2026-05-18T04:24:45.370170Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:24:45.370170Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"DV+fFpMFr1vXwozi9B9HjteRTZt9txuBbzEiYhdydZGxaanfwTUspQ5QRqG7peZqDXFGCw/v2bK07tGM0gNaDw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:24:45.370833Z","signed_message":"canonical_sha256_bytes"},"source_id":"0912.3952","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ed2380d7ac2c6d7656bafaef6c39786d23e1943cd48cc4dbefc4c0106867a333","sha256:f6983d7e93524bca865d6275bae9c5279544fc149ae5fcc47efaf5a0579e6676"],"state_sha256":"667addbe7c7953751eb638dca3ff6210b24a80b1b4329533f932787230c72098"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KBqNav3MqRwUZxt//6WqsulIGV/hx31D23u2qC/2YyzpS/2oUWThapCx9ms8Q1kZbAeZVPlegtyWErCXiewoAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T00:20:31.357527Z","bundle_sha256":"eeffcf5908aa6e40bc2a473c21b73189a9a4262420b80ec6df4972ad6b82c3eb"}}