{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2014:IRFY5QWMHDT7QP7YI6IOVC2DXH","short_pith_number":"pith:IRFY5QWM","schema_version":"1.0","canonical_sha256":"444b8ec2cc38e7f83ff84790ea8b43b9edc30b16fee8706e06d954a706304798","source":{"kind":"arxiv","id":"1406.0399","version":2},"attestation_state":"computed","paper":{"title":"Differential stoichiometry among core ribosomal proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM","q-bio.MN","q-bio.SC"],"primary_cat":"q-bio.GN","authors_text":"Alexander van Oudenaarden, Bogdan Budnik, Edoardo Airoldi, Nikolai Slavov, Sefan Semrau","submitted_at":"2014-06-02T14:57:33Z","abstract_excerpt":"Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition. Testing such variability requires direct and precise quantification of RPs. We used mass-spectrometry to directly quantify RPs across monosomes and polysomes of mouse embryonic stem cells (ESC) and budding yeast. Our data show that the stoichiometry among core RPs in wild-type yeast cells and ESC depends b"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1406.0399","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-06-02T14:57:33Z","cross_cats_sorted":["q-bio.BM","q-bio.MN","q-bio.SC"],"title_canon_sha256":"962db1e12db39791c1d4816321fc0bb8eaa25467d2a5d9ff83ad9dbe7d53abf1","abstract_canon_sha256":"693fd59136cd8cacde479b8f5125e2e778e61029964f0820b8e3633b5dd00d42"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:26:19.031394Z","signature_b64":"WmOLOb4nvTivIsn3v/Pb+OcKGe0qzas/TbgBopHHQWMIo7T63wrsaHXg5db3CkPFmVsXpn6l+nNGjxP61jpjDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"444b8ec2cc38e7f83ff84790ea8b43b9edc30b16fee8706e06d954a706304798","last_reissued_at":"2026-05-18T01:26:19.030969Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:26:19.030969Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Differential stoichiometry among core ribosomal proteins","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.BM","q-bio.MN","q-bio.SC"],"primary_cat":"q-bio.GN","authors_text":"Alexander van Oudenaarden, Bogdan Budnik, Edoardo Airoldi, Nikolai Slavov, Sefan Semrau","submitted_at":"2014-06-02T14:57:33Z","abstract_excerpt":"Understanding the regulation and structure of ribosomes is essential to understanding protein synthesis and its deregulation in disease. While ribosomes are believed to have a fixed stoichiometry among their core ribosomal proteins (RPs), some experiments suggest a more variable composition. Testing such variability requires direct and precise quantification of RPs. We used mass-spectrometry to directly quantify RPs across monosomes and polysomes of mouse embryonic stem cells (ESC) and budding yeast. Our data show that the stoichiometry among core RPs in wild-type yeast cells and ESC depends b"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1406.0399","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1406.0399","created_at":"2026-05-18T01:26:19.031032+00:00"},{"alias_kind":"arxiv_version","alias_value":"1406.0399v2","created_at":"2026-05-18T01:26:19.031032+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1406.0399","created_at":"2026-05-18T01:26:19.031032+00:00"},{"alias_kind":"pith_short_12","alias_value":"IRFY5QWMHDT7","created_at":"2026-05-18T12:28:33.132498+00:00"},{"alias_kind":"pith_short_16","alias_value":"IRFY5QWMHDT7QP7Y","created_at":"2026-05-18T12:28:33.132498+00:00"},{"alias_kind":"pith_short_8","alias_value":"IRFY5QWM","created_at":"2026-05-18T12:28:33.132498+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH","json":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH.json","graph_json":"https://pith.science/api/pith-number/IRFY5QWMHDT7QP7YI6IOVC2DXH/graph.json","events_json":"https://pith.science/api/pith-number/IRFY5QWMHDT7QP7YI6IOVC2DXH/events.json","paper":"https://pith.science/paper/IRFY5QWM"},"agent_actions":{"view_html":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH","download_json":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH.json","view_paper":"https://pith.science/paper/IRFY5QWM","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1406.0399&json=true","fetch_graph":"https://pith.science/api/pith-number/IRFY5QWMHDT7QP7YI6IOVC2DXH/graph.json","fetch_events":"https://pith.science/api/pith-number/IRFY5QWMHDT7QP7YI6IOVC2DXH/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH/action/timestamp_anchor","attest_storage":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH/action/storage_attestation","attest_author":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH/action/author_attestation","sign_citation":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH/action/citation_signature","submit_replication":"https://pith.science/pith/IRFY5QWMHDT7QP7YI6IOVC2DXH/action/replication_record"}},"created_at":"2026-05-18T01:26:19.031032+00:00","updated_at":"2026-05-18T01:26:19.031032+00:00"}