{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2024:IRGLZI76N72F7FD6Q7US4M7UBR","short_pith_number":"pith:IRGLZI76","schema_version":"1.0","canonical_sha256":"444cbca3fe6ff45f947e87e92e33f40c60cd25bc0b810a73d4f68568f2620b39","source":{"kind":"arxiv","id":"2403.16179","version":1},"attestation_state":"computed","paper":{"title":"Isoleucine gate blocks K+ conduction in C-type inactivation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Beno\\^it Roux, Bernardo I. Pinto, Carlos A. Z. Bassetto Jr, Christophe Chipot, Francisco Bezanilla, Jo\\~ao Alves, Werner Treptow, Yichen Liu","submitted_at":"2024-03-24T14:39:15Z","abstract_excerpt":"Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter toward a non-conductive state. Recently, a high-resolution structure of a strongly inactivating triple-mutant channel kv1.2-kv2.1-3m revealed a novel conformation of the selectivity filter that is dilated at its outer end, distinct from the well-characterized conductive state. While the experimental structure was interpreted as the "},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"2403.16179","kind":"arxiv","version":1},"metadata":{"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"physics.bio-ph","submitted_at":"2024-03-24T14:39:15Z","cross_cats_sorted":["q-bio.BM"],"title_canon_sha256":"afe766d58f49c5480754ed0666a11f5a335b7aca0e97803542caa54693853ce8","abstract_canon_sha256":"be155fb4107aac2d32a9146eb197bd210d49b893e9d0ea9952cbc0fcf2757af9"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T08:00:11.551163Z","signature_b64":"M1KUJVtymaUE9RLxYFrhg4wcF1iGOaSfBZE0pWkEPLFDbsP6TPwALBMfLAEaJz3UT2C5SOYnFH0CiRip2vCQBw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"444cbca3fe6ff45f947e87e92e33f40c60cd25bc0b810a73d4f68568f2620b39","last_reissued_at":"2026-07-05T08:00:11.550782Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T08:00:11.550782Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Isoleucine gate blocks K+ conduction in C-type inactivation","license":"http://creativecommons.org/licenses/by/4.0/","headline":"","cross_cats":["q-bio.BM"],"primary_cat":"physics.bio-ph","authors_text":"Beno\\^it Roux, Bernardo I. Pinto, Carlos A. Z. Bassetto Jr, Christophe Chipot, Francisco Bezanilla, Jo\\~ao Alves, Werner Treptow, Yichen Liu","submitted_at":"2024-03-24T14:39:15Z","abstract_excerpt":"Many voltage-gated potassium (Kv) channels display a time-dependent phenomenon called C-type inactivation, whereby prolonged activation by voltage leads to the inhibition of ionic conduction, a process that involves a conformational change at the selectivity filter toward a non-conductive state. Recently, a high-resolution structure of a strongly inactivating triple-mutant channel kv1.2-kv2.1-3m revealed a novel conformation of the selectivity filter that is dilated at its outer end, distinct from the well-characterized conductive state. While the experimental structure was interpreted as the "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2403.16179","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2403.16179/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"2403.16179","created_at":"2026-07-05T08:00:11.550839+00:00"},{"alias_kind":"arxiv_version","alias_value":"2403.16179v1","created_at":"2026-07-05T08:00:11.550839+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2403.16179","created_at":"2026-07-05T08:00:11.550839+00:00"},{"alias_kind":"pith_short_12","alias_value":"IRGLZI76N72F","created_at":"2026-07-05T08:00:11.550839+00:00"},{"alias_kind":"pith_short_16","alias_value":"IRGLZI76N72F7FD6","created_at":"2026-07-05T08:00:11.550839+00:00"},{"alias_kind":"pith_short_8","alias_value":"IRGLZI76","created_at":"2026-07-05T08:00:11.550839+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":1,"internal_anchor_count":1,"sample":[{"citing_arxiv_id":"2411.18931","citing_title":"A potassium ion channel simulated with a universal neural network potential","ref_index":21,"is_internal_anchor":true}]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR","json":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR.json","graph_json":"https://pith.science/api/pith-number/IRGLZI76N72F7FD6Q7US4M7UBR/graph.json","events_json":"https://pith.science/api/pith-number/IRGLZI76N72F7FD6Q7US4M7UBR/events.json","paper":"https://pith.science/paper/IRGLZI76"},"agent_actions":{"view_html":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR","download_json":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR.json","view_paper":"https://pith.science/paper/IRGLZI76","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=2403.16179&json=true","fetch_graph":"https://pith.science/api/pith-number/IRGLZI76N72F7FD6Q7US4M7UBR/graph.json","fetch_events":"https://pith.science/api/pith-number/IRGLZI76N72F7FD6Q7US4M7UBR/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR/action/timestamp_anchor","attest_storage":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR/action/storage_attestation","attest_author":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR/action/author_attestation","sign_citation":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR/action/citation_signature","submit_replication":"https://pith.science/pith/IRGLZI76N72F7FD6Q7US4M7UBR/action/replication_record"}},"created_at":"2026-07-05T08:00:11.550839+00:00","updated_at":"2026-07-05T08:00:11.550839+00:00"}