{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:IRKOK4VKTVZONB42RM2PHROJF3","short_pith_number":"pith:IRKOK4VK","schema_version":"1.0","canonical_sha256":"4454e572aa9d72e6879a8b34f3c5c92efdbc48a08654af01c5a2d14a37c27d18","source":{"kind":"arxiv","id":"1510.05850","version":1},"attestation_state":"computed","paper":{"title":"Discrete gene replication events drive coupling between the cell cycle and circadian clocks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"David K. Lubensky, Joris Paijmans, Mark Bosman, Pieter Rein ten Wolde","submitted_at":"2015-10-20T12:12:31Z","abstract_excerpt":"Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a non-specific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the cell cycle cause a periodic driving of the circadian clock, which can dramatically alter its behavior and impair its funct"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1510.05850","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-10-20T12:12:31Z","cross_cats_sorted":[],"title_canon_sha256":"bc43d8bd7351749aa12888fb9f8315f611cf636197f5274e2a2fd6b0ef1272c8","abstract_canon_sha256":"ef0d6864da9b0e1574f20ca6d23a55bbd23b10b1ade9f211fbc49b7aad415967"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:17:25.237367Z","signature_b64":"c6wjtsNXll+O2XmxvaYzlfK2zrY28igei8z/AWq9ibD3g6QJ8vjos2WeuMuj+sBmVRM4jP89GkoYDQbgKsnoAg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4454e572aa9d72e6879a8b34f3c5c92efdbc48a08654af01c5a2d14a37c27d18","last_reissued_at":"2026-05-18T01:17:25.236887Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:17:25.236887Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Discrete gene replication events drive coupling between the cell cycle and circadian clocks","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"David K. Lubensky, Joris Paijmans, Mark Bosman, Pieter Rein ten Wolde","submitted_at":"2015-10-20T12:12:31Z","abstract_excerpt":"Many organisms possess both a cell cycle to control DNA replication and a circadian clock to anticipate changes between day and night. In some cases, these two rhythmic systems are known to be coupled by specific, cross-regulatory interactions. Here, we use mathematical modeling to show that, additionally, the cell cycle generically influences circadian clocks in a non-specific fashion: The regular, discrete jumps in gene-copy number arising from DNA replication during the cell cycle cause a periodic driving of the circadian clock, which can dramatically alter its behavior and impair its funct"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1510.05850","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1510.05850","created_at":"2026-05-18T01:17:25.236954+00:00"},{"alias_kind":"arxiv_version","alias_value":"1510.05850v1","created_at":"2026-05-18T01:17:25.236954+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1510.05850","created_at":"2026-05-18T01:17:25.236954+00:00"},{"alias_kind":"pith_short_12","alias_value":"IRKOK4VKTVZO","created_at":"2026-05-18T12:29:25.134429+00:00"},{"alias_kind":"pith_short_16","alias_value":"IRKOK4VKTVZONB42","created_at":"2026-05-18T12:29:25.134429+00:00"},{"alias_kind":"pith_short_8","alias_value":"IRKOK4VK","created_at":"2026-05-18T12:29:25.134429+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3","json":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3.json","graph_json":"https://pith.science/api/pith-number/IRKOK4VKTVZONB42RM2PHROJF3/graph.json","events_json":"https://pith.science/api/pith-number/IRKOK4VKTVZONB42RM2PHROJF3/events.json","paper":"https://pith.science/paper/IRKOK4VK"},"agent_actions":{"view_html":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3","download_json":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3.json","view_paper":"https://pith.science/paper/IRKOK4VK","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1510.05850&json=true","fetch_graph":"https://pith.science/api/pith-number/IRKOK4VKTVZONB42RM2PHROJF3/graph.json","fetch_events":"https://pith.science/api/pith-number/IRKOK4VKTVZONB42RM2PHROJF3/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3/action/timestamp_anchor","attest_storage":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3/action/storage_attestation","attest_author":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3/action/author_attestation","sign_citation":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3/action/citation_signature","submit_replication":"https://pith.science/pith/IRKOK4VKTVZONB42RM2PHROJF3/action/replication_record"}},"created_at":"2026-05-18T01:17:25.236954+00:00","updated_at":"2026-05-18T01:17:25.236954+00:00"}