{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2025:IUHH2S72CFRZBWPRKBIQ4TV2J3","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8363f330cfaad3aa3c9c689d5cba56350e1c8ac919ff6f53ae2c092765d401ed","cross_cats_sorted":["cs.CL","cs.MA"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-27T12:57:00Z","title_canon_sha256":"eaaff3720b8cf31cb8aafc125fff8f3fa96f21827825a912932bb83a4c3f6c6a"},"schema_version":"1.0","source":{"id":"2506.22189","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2506.22189","created_at":"2026-07-05T11:56:58Z"},{"alias_kind":"arxiv_version","alias_value":"2506.22189v2","created_at":"2026-07-05T11:56:58Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2506.22189","created_at":"2026-07-05T11:56:58Z"},{"alias_kind":"pith_short_12","alias_value":"IUHH2S72CFRZ","created_at":"2026-07-05T11:56:58Z"},{"alias_kind":"pith_short_16","alias_value":"IUHH2S72CFRZBWPR","created_at":"2026-07-05T11:56:58Z"},{"alias_kind":"pith_short_8","alias_value":"IUHH2S72","created_at":"2026-07-05T11:56:58Z"}],"graph_snapshots":[{"event_id":"sha256:a6f9d262029aae3b8666dcb53ab76abd933afc845a37033708748f856d8c6340","target":"graph","created_at":"2026-07-05T11:56:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2506.22189/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Large-language models (LLMs) and agentic systems present exciting opportunities to accelerate drug discovery. In this study, we examine the modularity of LLM-based agentic systems for drug discovery, i.e., whether parts of the system such as the LLM and type of agent are interchangeable, a topic that has received limited attention in drug discovery. We compare the performance of different LLMs and the effectiveness of tool-calling agents versus code-generating agents. Our case study, comparing performance in orchestrating tools for chemistry and drug discovery using an LLM-as-a-judge score, sh","authors_text":"Jens Sj\\\"olund, Laura van Weesep, Ola Engkvist, Samuel Genheden","cross_cats":["cs.CL","cs.MA"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-27T12:57:00Z","title":"Exploring Modularity of Agentic Systems for Drug Discovery"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2506.22189","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:e99ab4a745713bc3c181a4010cb54168d6536f79a7f165a1cbc23e8a4fddaa97","target":"record","created_at":"2026-07-05T11:56:58Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8363f330cfaad3aa3c9c689d5cba56350e1c8ac919ff6f53ae2c092765d401ed","cross_cats_sorted":["cs.CL","cs.MA"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"cs.LG","submitted_at":"2025-06-27T12:57:00Z","title_canon_sha256":"eaaff3720b8cf31cb8aafc125fff8f3fa96f21827825a912932bb83a4c3f6c6a"},"schema_version":"1.0","source":{"id":"2506.22189","kind":"arxiv","version":2}},"canonical_sha256":"450e7d4bfa116390d9f150510e4eba4ed248ce68069e6eca5bd577d01023ba9a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"450e7d4bfa116390d9f150510e4eba4ed248ce68069e6eca5bd577d01023ba9a","first_computed_at":"2026-07-05T11:56:58.627549Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T11:56:58.627549Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"3nKNlkSIcUbpvUEo9jIzjD33ped5WojfMdMnoOuK6mQ3ok0Ng5bmEC/Pod2Kg5ofW2LiT08XqR6QTTem661TCA==","signature_status":"signed_v1","signed_at":"2026-07-05T11:56:58.628143Z","signed_message":"canonical_sha256_bytes"},"source_id":"2506.22189","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:e99ab4a745713bc3c181a4010cb54168d6536f79a7f165a1cbc23e8a4fddaa97","sha256:a6f9d262029aae3b8666dcb53ab76abd933afc845a37033708748f856d8c6340"],"state_sha256":"77aab0e473abbc087306a6731e8b299cb8207b6b8a23cf8c735ce9e5aaffd19f"}