{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2009:IXDCWXUQOMIAZSM7E5ULI53UMG","short_pith_number":"pith:IXDCWXUQ","canonical_record":{"source":{"id":"0902.1730","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2009-02-10T19:46:00Z","cross_cats_sorted":["physics.bio-ph","physics.med-ph"],"title_canon_sha256":"cbe8f66e68a1bdcf7e8dfd19646f0f1695242bb14c4d416fcdbbb0dde2dc695f","abstract_canon_sha256":"f2a87093f6b25725827af155b5884028aae5e7b70a7e9987858f55bbf9ab62e0"},"schema_version":"1.0"},"canonical_sha256":"45c62b5e9073100cc99f2768b4777461bb2b78757338c840b1f2a20dcbbc0c53","source":{"kind":"arxiv","id":"0902.1730","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0902.1730","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"arxiv_version","alias_value":"0902.1730v1","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0902.1730","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"pith_short_12","alias_value":"IXDCWXUQOMIA","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_16","alias_value":"IXDCWXUQOMIAZSM7","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_8","alias_value":"IXDCWXUQ","created_at":"2026-05-18T12:26:00Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2009:IXDCWXUQOMIAZSM7E5ULI53UMG","target":"record","payload":{"canonical_record":{"source":{"id":"0902.1730","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2009-02-10T19:46:00Z","cross_cats_sorted":["physics.bio-ph","physics.med-ph"],"title_canon_sha256":"cbe8f66e68a1bdcf7e8dfd19646f0f1695242bb14c4d416fcdbbb0dde2dc695f","abstract_canon_sha256":"f2a87093f6b25725827af155b5884028aae5e7b70a7e9987858f55bbf9ab62e0"},"schema_version":"1.0"},"canonical_sha256":"45c62b5e9073100cc99f2768b4777461bb2b78757338c840b1f2a20dcbbc0c53","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:42:04.016796Z","signature_b64":"V+n899Owj6QeMgX1Yqr1+SQzXPXJV2OygC12coM67IpObjzKBG2j+6nKu30KAWW7epxXKw+GEmqouDawe+g+Aw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"45c62b5e9073100cc99f2768b4777461bb2b78757338c840b1f2a20dcbbc0c53","last_reissued_at":"2026-05-18T04:42:04.016370Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:42:04.016370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"0902.1730","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:42:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+TLeOF4izxJoQTdvA6YP9iJ7aU8Hq7yiZAW/DIbWrqenzU+pLTiDS4vd4MdM3RNf3Bk5vOhJOpsJJLwciDq5Dw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T02:52:33.004077Z"},"content_sha256":"ed6e0152e4a2e9429283862b01bb9d71ddddfde3259a24408874f30b95ecbe45","schema_version":"1.0","event_id":"sha256:ed6e0152e4a2e9429283862b01bb9d71ddddfde3259a24408874f30b95ecbe45"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2009:IXDCWXUQOMIAZSM7E5ULI53UMG","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Homeostatic competition drives tumor growth and metastasis nucleation","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["physics.bio-ph","physics.med-ph"],"primary_cat":"q-bio.TO","authors_text":"Jacques Prost, Jean-Francois Joanny, Markus Basan, Thomas Risler, Xavier Sastre-Garau","submitted_at":"2009-02-10T19:46:00Z","abstract_excerpt":"We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed preferential growth of metastases on tissue surfaces and membranes such as the pleural and peritoneal l"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0902.1730","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:42:04Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"1BaOSDs0XcJ9Hq++W8grxSLsfFbd9L4Ymhb3V88gFT/emAdqNoCSnrnKWdDz9BsLJU8JF0x9yNXJ95oFNTyZAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-27T02:52:33.004768Z"},"content_sha256":"e9b3c3b93989b14b7b23eb052ef675600689ba046a275f5be1b1d26a5aceb414","schema_version":"1.0","event_id":"sha256:e9b3c3b93989b14b7b23eb052ef675600689ba046a275f5be1b1d26a5aceb414"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/bundle.json","state_url":"https://pith.science/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-27T02:52:33Z","links":{"resolver":"https://pith.science/pith/IXDCWXUQOMIAZSM7E5ULI53UMG","bundle":"https://pith.science/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/bundle.json","state":"https://pith.science/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/state.json","well_known_bundle":"https://pith.science/.well-known/pith/IXDCWXUQOMIAZSM7E5ULI53UMG/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2009:IXDCWXUQOMIAZSM7E5ULI53UMG","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"f2a87093f6b25725827af155b5884028aae5e7b70a7e9987858f55bbf9ab62e0","cross_cats_sorted":["physics.bio-ph","physics.med-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2009-02-10T19:46:00Z","title_canon_sha256":"cbe8f66e68a1bdcf7e8dfd19646f0f1695242bb14c4d416fcdbbb0dde2dc695f"},"schema_version":"1.0","source":{"id":"0902.1730","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"0902.1730","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"arxiv_version","alias_value":"0902.1730v1","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.0902.1730","created_at":"2026-05-18T04:42:04Z"},{"alias_kind":"pith_short_12","alias_value":"IXDCWXUQOMIA","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_16","alias_value":"IXDCWXUQOMIAZSM7","created_at":"2026-05-18T12:26:00Z"},{"alias_kind":"pith_short_8","alias_value":"IXDCWXUQ","created_at":"2026-05-18T12:26:00Z"}],"graph_snapshots":[{"event_id":"sha256:e9b3c3b93989b14b7b23eb052ef675600689ba046a275f5be1b1d26a5aceb414","target":"graph","created_at":"2026-05-18T04:42:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"We propose a mechanism for tumor growth emphasizing the role of homeostatic regulation and tissue stability. We show that competition between surface and bulk effects leads to the existence of a critical size that must be overcome by metastases to reach macroscopic sizes. This property can qualitatively explain the observed size distributions of metastases, while size-independent growth rates cannot account for clinical and experimental data. In addition, it potentially explains the observed preferential growth of metastases on tissue surfaces and membranes such as the pleural and peritoneal l","authors_text":"Jacques Prost, Jean-Francois Joanny, Markus Basan, Thomas Risler, Xavier Sastre-Garau","cross_cats":["physics.bio-ph","physics.med-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2009-02-10T19:46:00Z","title":"Homeostatic competition drives tumor growth and metastasis nucleation"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"0902.1730","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ed6e0152e4a2e9429283862b01bb9d71ddddfde3259a24408874f30b95ecbe45","target":"record","created_at":"2026-05-18T04:42:04Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"f2a87093f6b25725827af155b5884028aae5e7b70a7e9987858f55bbf9ab62e0","cross_cats_sorted":["physics.bio-ph","physics.med-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.TO","submitted_at":"2009-02-10T19:46:00Z","title_canon_sha256":"cbe8f66e68a1bdcf7e8dfd19646f0f1695242bb14c4d416fcdbbb0dde2dc695f"},"schema_version":"1.0","source":{"id":"0902.1730","kind":"arxiv","version":1}},"canonical_sha256":"45c62b5e9073100cc99f2768b4777461bb2b78757338c840b1f2a20dcbbc0c53","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"45c62b5e9073100cc99f2768b4777461bb2b78757338c840b1f2a20dcbbc0c53","first_computed_at":"2026-05-18T04:42:04.016370Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:42:04.016370Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"V+n899Owj6QeMgX1Yqr1+SQzXPXJV2OygC12coM67IpObjzKBG2j+6nKu30KAWW7epxXKw+GEmqouDawe+g+Aw==","signature_status":"signed_v1","signed_at":"2026-05-18T04:42:04.016796Z","signed_message":"canonical_sha256_bytes"},"source_id":"0902.1730","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ed6e0152e4a2e9429283862b01bb9d71ddddfde3259a24408874f30b95ecbe45","sha256:e9b3c3b93989b14b7b23eb052ef675600689ba046a275f5be1b1d26a5aceb414"],"state_sha256":"283098eb5ae93d7ad95ba7fd79cbda6a8ea41e273a06c4c6b82d68be7fb9b9a9"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"/mm8pWqh2L3XM18RQCostYZ6coDhrXdb+dIVS1F5BhcoDQCrOUac0ET/zGXgg8LQmpei+5GH6XaigWzoV30zDw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-27T02:52:33.008239Z","bundle_sha256":"f8f96281c03a19289075a06a1e8a370f2c1cbceb5e759168f10c8208eca01533"}}