{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2015:IYPGXGGE7LQLVVDTCONPF7EPGG","short_pith_number":"pith:IYPGXGGE","schema_version":"1.0","canonical_sha256":"461e6b98c4fae0bad473139af2fc8f31a9a2772be1370594790df0cb8aba67c3","source":{"kind":"arxiv","id":"1512.01476","version":3},"attestation_state":"computed","paper":{"title":"Spatial fluctuations at vertices of epithelial layers: quantification of regulation by Rho pathway","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft","cond-mat.stat-mech"],"primary_cat":"physics.bio-ph","authors_text":"D. Riveline, \\'E. Fodor, F. van Wijland, J. Comelles, N. S. Gov, P. Visco, R. Thiagarajan, V. Mehandia","submitted_at":"2015-12-04T16:37:21Z","abstract_excerpt":"In living matter, shape fluctuations induced by acto-myosin are usually studied in vitro via reconstituted gels, whose properties are controlled by changing the concentrations of actin, myosin and cross-linkers. Such an approach deliberately avoids to consider the complexity of biochemical signaling inherent to living systems. Acto-myosin activity inside living cells is mainly regulated by the Rho signaling pathway which is composed of multiple layers of coupled activators and inhibitors. We investigate how such a pathway controls the dynamics of confluent epithelial tissues by tracking the di"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"1512.01476","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-04T16:37:21Z","cross_cats_sorted":["cond-mat.soft","cond-mat.stat-mech"],"title_canon_sha256":"8746893d44d84c9384fe73eab01cc0f6d0723950bfce25a960874fce4eaa2053","abstract_canon_sha256":"ccf815b5a6fc4e6aff93e458900684655c2d39095f3ebe9937fdb4b4d2e2dc77"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T00:22:21.350420Z","signature_b64":"/I0XA7TCSCOdBWO/F+ppjXyu7J0aELh4Wl8DWIG/KYBTc+FdOoQmx8jO4CedDiyDzK9atG3VBkiovvun6iNLBQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"461e6b98c4fae0bad473139af2fc8f31a9a2772be1370594790df0cb8aba67c3","last_reissued_at":"2026-05-18T00:22:21.349741Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T00:22:21.349741Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Spatial fluctuations at vertices of epithelial layers: quantification of regulation by Rho pathway","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.soft","cond-mat.stat-mech"],"primary_cat":"physics.bio-ph","authors_text":"D. Riveline, \\'E. Fodor, F. van Wijland, J. Comelles, N. S. Gov, P. Visco, R. Thiagarajan, V. Mehandia","submitted_at":"2015-12-04T16:37:21Z","abstract_excerpt":"In living matter, shape fluctuations induced by acto-myosin are usually studied in vitro via reconstituted gels, whose properties are controlled by changing the concentrations of actin, myosin and cross-linkers. Such an approach deliberately avoids to consider the complexity of biochemical signaling inherent to living systems. Acto-myosin activity inside living cells is mainly regulated by the Rho signaling pathway which is composed of multiple layers of coupled activators and inhibitors. We investigate how such a pathway controls the dynamics of confluent epithelial tissues by tracking the di"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.01476","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"1512.01476","created_at":"2026-05-18T00:22:21.349837+00:00"},{"alias_kind":"arxiv_version","alias_value":"1512.01476v3","created_at":"2026-05-18T00:22:21.349837+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.01476","created_at":"2026-05-18T00:22:21.349837+00:00"},{"alias_kind":"pith_short_12","alias_value":"IYPGXGGE7LQL","created_at":"2026-05-18T12:29:27.538025+00:00"},{"alias_kind":"pith_short_16","alias_value":"IYPGXGGE7LQLVVDT","created_at":"2026-05-18T12:29:27.538025+00:00"},{"alias_kind":"pith_short_8","alias_value":"IYPGXGGE","created_at":"2026-05-18T12:29:27.538025+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG","json":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG.json","graph_json":"https://pith.science/api/pith-number/IYPGXGGE7LQLVVDTCONPF7EPGG/graph.json","events_json":"https://pith.science/api/pith-number/IYPGXGGE7LQLVVDTCONPF7EPGG/events.json","paper":"https://pith.science/paper/IYPGXGGE"},"agent_actions":{"view_html":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG","download_json":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG.json","view_paper":"https://pith.science/paper/IYPGXGGE","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=1512.01476&json=true","fetch_graph":"https://pith.science/api/pith-number/IYPGXGGE7LQLVVDTCONPF7EPGG/graph.json","fetch_events":"https://pith.science/api/pith-number/IYPGXGGE7LQLVVDTCONPF7EPGG/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG/action/timestamp_anchor","attest_storage":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG/action/storage_attestation","attest_author":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG/action/author_attestation","sign_citation":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG/action/citation_signature","submit_replication":"https://pith.science/pith/IYPGXGGE7LQLVVDTCONPF7EPGG/action/replication_record"}},"created_at":"2026-05-18T00:22:21.349837+00:00","updated_at":"2026-05-18T00:22:21.349837+00:00"}