{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2012:J32HLN2UZAQWKWRPH5AF6S6OVH","short_pith_number":"pith:J32HLN2U","canonical_record":{"source":{"id":"1202.3015","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-14T12:24:09Z","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"title_canon_sha256":"9c14d54a5c64b02bcf47a2638b4f970c6f095a8072e003b73fde4aada589e466","abstract_canon_sha256":"65ff5285668b186f30ab14fced67580a6d735198931a367447d8faa28c9c1690"},"schema_version":"1.0"},"canonical_sha256":"4ef475b754c821655a2f3f405f4bcea9c3abba6bff542891af9ab419219f8722","source":{"kind":"arxiv","id":"1202.3015","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.3015","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"arxiv_version","alias_value":"1202.3015v2","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.3015","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"pith_short_12","alias_value":"J32HLN2UZAQW","created_at":"2026-05-18T12:27:09Z"},{"alias_kind":"pith_short_16","alias_value":"J32HLN2UZAQWKWRP","created_at":"2026-05-18T12:27:09Z"},{"alias_kind":"pith_short_8","alias_value":"J32HLN2U","created_at":"2026-05-18T12:27:09Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2012:J32HLN2UZAQWKWRPH5AF6S6OVH","target":"record","payload":{"canonical_record":{"source":{"id":"1202.3015","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-14T12:24:09Z","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"title_canon_sha256":"9c14d54a5c64b02bcf47a2638b4f970c6f095a8072e003b73fde4aada589e466","abstract_canon_sha256":"65ff5285668b186f30ab14fced67580a6d735198931a367447d8faa28c9c1690"},"schema_version":"1.0"},"canonical_sha256":"4ef475b754c821655a2f3f405f4bcea9c3abba6bff542891af9ab419219f8722","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:40:16.266865Z","signature_b64":"Z0gLao2T+x8o3KLElcHiJ/Bym3Wd0BjKD3oAVhI4eJmO14ndIYmq+cj9whf1G1Hyv9257NTjUI8fdzahPqH7CA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4ef475b754c821655a2f3f405f4bcea9c3abba6bff542891af9ab419219f8722","last_reissued_at":"2026-05-18T03:40:16.266284Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:40:16.266284Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1202.3015","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:40:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"fn5gK4RbosgG7Bxy2ickPYgAdwZM3j9UN/kOFkDRgprt7U7CwPFY+KYjYWNo6pcg0wTd4P+yokLHRFSQI4MGCw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T13:12:47.327479Z"},"content_sha256":"a2476ef8d7ed508bc83f0e0d4dce89ce0fd248c0498ad71ed1403856c96242a4","schema_version":"1.0","event_id":"sha256:a2476ef8d7ed508bc83f0e0d4dce89ce0fd248c0498ad71ed1403856c96242a4"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2012:J32HLN2UZAQWKWRPH5AF6S6OVH","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"On dynamic network entropy in cancer","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"primary_cat":"q-bio.MN","authors_text":"Andrew Teschendorff, Ginestra Bianconi, James West, Simone Severini","submitted_at":"2012-02-14T12:24:09Z","abstract_excerpt":"The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level insights into disease mechanisms and ultimately for developing improved therapies. By integrating gene expression data with a protein interaction network to induce a stochastic dynamics on the network, we here demonstrate that cancer cells are characterised by an increase in the dynamic network entropy, compared to cells of normal physiology. Using a fundamental r"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.3015","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T03:40:16Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"XIGgXl5iyZv+OsidAhgvp+QtP73x44BT1686cFeuqv7oJMmFuI0Pr7IckqnvzZhVTipXi4nLWe53sXhNli/+Dw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T13:12:47.327902Z"},"content_sha256":"2b3b58e78ea7723c5029f273d7cd179e207a53fd96ecf23d7f112418fad326a8","schema_version":"1.0","event_id":"sha256:2b3b58e78ea7723c5029f273d7cd179e207a53fd96ecf23d7f112418fad326a8"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/bundle.json","state_url":"https://pith.science/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T13:12:47Z","links":{"resolver":"https://pith.science/pith/J32HLN2UZAQWKWRPH5AF6S6OVH","bundle":"https://pith.science/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/bundle.json","state":"https://pith.science/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/state.json","well_known_bundle":"https://pith.science/.well-known/pith/J32HLN2UZAQWKWRPH5AF6S6OVH/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2012:J32HLN2UZAQWKWRPH5AF6S6OVH","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"65ff5285668b186f30ab14fced67580a6d735198931a367447d8faa28c9c1690","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-14T12:24:09Z","title_canon_sha256":"9c14d54a5c64b02bcf47a2638b4f970c6f095a8072e003b73fde4aada589e466"},"schema_version":"1.0","source":{"id":"1202.3015","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1202.3015","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"arxiv_version","alias_value":"1202.3015v2","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1202.3015","created_at":"2026-05-18T03:40:16Z"},{"alias_kind":"pith_short_12","alias_value":"J32HLN2UZAQW","created_at":"2026-05-18T12:27:09Z"},{"alias_kind":"pith_short_16","alias_value":"J32HLN2UZAQWKWRP","created_at":"2026-05-18T12:27:09Z"},{"alias_kind":"pith_short_8","alias_value":"J32HLN2U","created_at":"2026-05-18T12:27:09Z"}],"graph_snapshots":[{"event_id":"sha256:2b3b58e78ea7723c5029f273d7cd179e207a53fd96ecf23d7f112418fad326a8","target":"graph","created_at":"2026-05-18T03:40:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The cellular phenotype is described by a complex network of molecular interactions. Elucidating network properties that distinguish disease from the healthy cellular state is therefore of critical importance for gaining systems-level insights into disease mechanisms and ultimately for developing improved therapies. By integrating gene expression data with a protein interaction network to induce a stochastic dynamics on the network, we here demonstrate that cancer cells are characterised by an increase in the dynamic network entropy, compared to cells of normal physiology. Using a fundamental r","authors_text":"Andrew Teschendorff, Ginestra Bianconi, James West, Simone Severini","cross_cats":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-14T12:24:09Z","title":"On dynamic network entropy in cancer"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1202.3015","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:a2476ef8d7ed508bc83f0e0d4dce89ce0fd248c0498ad71ed1403856c96242a4","target":"record","created_at":"2026-05-18T03:40:16Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"65ff5285668b186f30ab14fced67580a6d735198931a367447d8faa28c9c1690","cross_cats_sorted":["cond-mat.dis-nn","cond-mat.stat-mech","q-bio.GN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2012-02-14T12:24:09Z","title_canon_sha256":"9c14d54a5c64b02bcf47a2638b4f970c6f095a8072e003b73fde4aada589e466"},"schema_version":"1.0","source":{"id":"1202.3015","kind":"arxiv","version":2}},"canonical_sha256":"4ef475b754c821655a2f3f405f4bcea9c3abba6bff542891af9ab419219f8722","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4ef475b754c821655a2f3f405f4bcea9c3abba6bff542891af9ab419219f8722","first_computed_at":"2026-05-18T03:40:16.266284Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T03:40:16.266284Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"Z0gLao2T+x8o3KLElcHiJ/Bym3Wd0BjKD3oAVhI4eJmO14ndIYmq+cj9whf1G1Hyv9257NTjUI8fdzahPqH7CA==","signature_status":"signed_v1","signed_at":"2026-05-18T03:40:16.266865Z","signed_message":"canonical_sha256_bytes"},"source_id":"1202.3015","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:a2476ef8d7ed508bc83f0e0d4dce89ce0fd248c0498ad71ed1403856c96242a4","sha256:2b3b58e78ea7723c5029f273d7cd179e207a53fd96ecf23d7f112418fad326a8"],"state_sha256":"7c1f0806fdacb4ae2d8a4ff0c69f059393638481d3d662ba3fbc19e5bf888f75"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"QDud1y8WUwk+XS8HkfjyKwIr+9Pj3DCtwfZuXJtV+6qiTqPJytdh3r6HxoT0xqhjYg9fmkxAUxEQEO+Zt3JPAw==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T13:12:47.331258Z","bundle_sha256":"bd6be1601e574f75b3972d0674938287f0582a3db0ec06b0cede8a838ac1bc9c"}}