{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:J6KVIJEHTEIKLM26E2H46Q5FAB","short_pith_number":"pith:J6KVIJEH","canonical_record":{"source":{"id":"1407.3622","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-07-14T12:31:58Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"ebd70fef5ddee250b307d6f2b29ca42a5365507229f0c3503c1c879f250155be","abstract_canon_sha256":"7ea73ecb8603d9db9ceeda6631f0f2b3caeee47c2a991d11e194311d524c69c4"},"schema_version":"1.0"},"canonical_sha256":"4f955424879910a5b35e268fcf43a5005167c737c9862ac89f0a99331b477977","source":{"kind":"arxiv","id":"1407.3622","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1407.3622","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"arxiv_version","alias_value":"1407.3622v1","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1407.3622","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"pith_short_12","alias_value":"J6KVIJEHTEIK","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"J6KVIJEHTEIKLM26","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"J6KVIJEH","created_at":"2026-05-18T12:28:33Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:J6KVIJEHTEIKLM26E2H46Q5FAB","target":"record","payload":{"canonical_record":{"source":{"id":"1407.3622","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-07-14T12:31:58Z","cross_cats_sorted":["q-bio.MN"],"title_canon_sha256":"ebd70fef5ddee250b307d6f2b29ca42a5365507229f0c3503c1c879f250155be","abstract_canon_sha256":"7ea73ecb8603d9db9ceeda6631f0f2b3caeee47c2a991d11e194311d524c69c4"},"schema_version":"1.0"},"canonical_sha256":"4f955424879910a5b35e268fcf43a5005167c737c9862ac89f0a99331b477977","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:47:42.317364Z","signature_b64":"R8Yc+tCv99Ae86lhpdMZOQWnH63uB4AiTKiZe/3b2c5eMO+WOZIwSw+qf8k6KpXon0nE3caC6g/+AJHKDI4wAw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4f955424879910a5b35e268fcf43a5005167c737c9862ac89f0a99331b477977","last_reissued_at":"2026-05-18T02:47:42.316564Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:47:42.316564Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1407.3622","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:47:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"TkyAk8U5oAjg5hDWrsdf4FvuCgP0+1y8A7TIIvdE2zbh7NnPlt/umrJ8QmbWpy08jX02Zi77dnYP3GqkU2hABA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T20:14:26.974071Z"},"content_sha256":"ee3704037eb030e18b0e99656d3caeab27b1646e386406ccd5573e0346ee9558","schema_version":"1.0","event_id":"sha256:ee3704037eb030e18b0e99656d3caeab27b1646e386406ccd5573e0346ee9558"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:J6KVIJEHTEIKLM26E2H46Q5FAB","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Universal relationship in gene-expression changes for cells in steady-growth state","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.MN"],"primary_cat":"q-bio.CB","authors_text":"Chikara Furusawa, Kunihiko Kaneko, Tetsuya Yomo","submitted_at":"2014-07-14T12:31:58Z","abstract_excerpt":"Cells adapt to different conditions by altering a vast number of components, which is measurable using transcriptome analysis. Given that a cell undergoing steady growth is constrained to sustain each of its internal components, the abundance of all the components in the cell has to be roughly doubled during each cell division event. From this steady-growth constraint, expression of all genes is shown to change along a one-parameter curve in the state space in response to the environmental stress. This leads to a global relationship that governs the cellular state: By considering a relatively "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.3622","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:47:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"gcnrK4zHyMohux8P3E4ZH/vss2F90HRmrIP4lNVtaxS6sVPm8355d9Wk9APlAj3i8+YJDsMhRHB1S86i6fwqAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-25T20:14:26.974458Z"},"content_sha256":"1e4a9c59dcdbb71079a750b4d53f08969f8c9687a9ff972a109d1712a4231071","schema_version":"1.0","event_id":"sha256:1e4a9c59dcdbb71079a750b4d53f08969f8c9687a9ff972a109d1712a4231071"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/bundle.json","state_url":"https://pith.science/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-25T20:14:26Z","links":{"resolver":"https://pith.science/pith/J6KVIJEHTEIKLM26E2H46Q5FAB","bundle":"https://pith.science/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/bundle.json","state":"https://pith.science/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/state.json","well_known_bundle":"https://pith.science/.well-known/pith/J6KVIJEHTEIKLM26E2H46Q5FAB/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:J6KVIJEHTEIKLM26E2H46Q5FAB","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7ea73ecb8603d9db9ceeda6631f0f2b3caeee47c2a991d11e194311d524c69c4","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-07-14T12:31:58Z","title_canon_sha256":"ebd70fef5ddee250b307d6f2b29ca42a5365507229f0c3503c1c879f250155be"},"schema_version":"1.0","source":{"id":"1407.3622","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1407.3622","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"arxiv_version","alias_value":"1407.3622v1","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1407.3622","created_at":"2026-05-18T02:47:42Z"},{"alias_kind":"pith_short_12","alias_value":"J6KVIJEHTEIK","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"J6KVIJEHTEIKLM26","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"J6KVIJEH","created_at":"2026-05-18T12:28:33Z"}],"graph_snapshots":[{"event_id":"sha256:1e4a9c59dcdbb71079a750b4d53f08969f8c9687a9ff972a109d1712a4231071","target":"graph","created_at":"2026-05-18T02:47:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Cells adapt to different conditions by altering a vast number of components, which is measurable using transcriptome analysis. Given that a cell undergoing steady growth is constrained to sustain each of its internal components, the abundance of all the components in the cell has to be roughly doubled during each cell division event. From this steady-growth constraint, expression of all genes is shown to change along a one-parameter curve in the state space in response to the environmental stress. This leads to a global relationship that governs the cellular state: By considering a relatively ","authors_text":"Chikara Furusawa, Kunihiko Kaneko, Tetsuya Yomo","cross_cats":["q-bio.MN"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-07-14T12:31:58Z","title":"Universal relationship in gene-expression changes for cells in steady-growth state"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1407.3622","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:ee3704037eb030e18b0e99656d3caeab27b1646e386406ccd5573e0346ee9558","target":"record","created_at":"2026-05-18T02:47:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7ea73ecb8603d9db9ceeda6631f0f2b3caeee47c2a991d11e194311d524c69c4","cross_cats_sorted":["q-bio.MN"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.CB","submitted_at":"2014-07-14T12:31:58Z","title_canon_sha256":"ebd70fef5ddee250b307d6f2b29ca42a5365507229f0c3503c1c879f250155be"},"schema_version":"1.0","source":{"id":"1407.3622","kind":"arxiv","version":1}},"canonical_sha256":"4f955424879910a5b35e268fcf43a5005167c737c9862ac89f0a99331b477977","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4f955424879910a5b35e268fcf43a5005167c737c9862ac89f0a99331b477977","first_computed_at":"2026-05-18T02:47:42.316564Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:47:42.316564Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"R8Yc+tCv99Ae86lhpdMZOQWnH63uB4AiTKiZe/3b2c5eMO+WOZIwSw+qf8k6KpXon0nE3caC6g/+AJHKDI4wAw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:47:42.317364Z","signed_message":"canonical_sha256_bytes"},"source_id":"1407.3622","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:ee3704037eb030e18b0e99656d3caeab27b1646e386406ccd5573e0346ee9558","sha256:1e4a9c59dcdbb71079a750b4d53f08969f8c9687a9ff972a109d1712a4231071"],"state_sha256":"d74dbc57ecd061e894a5430f1cbc99ce71b6d793a9aafb335491a1565e831846"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"BLUZQKEQ86V5J2O4Ox3BAaytglzIdE2z1g8nb3INl21sbu6U+8M2O5c98uCZiv1NnaVb/8yOr4Xk7dwij9N7Cg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-25T20:14:26.977580Z","bundle_sha256":"3f1565cb2d40046c81192e2c86e55a006b358cbac6d18fa065e5222c159affdc"}}