{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2019:J77QLTWVXKIFCNUI3K5KEUYFUD","short_pith_number":"pith:J77QLTWV","canonical_record":{"source":{"id":"1910.13200","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-10-29T11:16:25Z","cross_cats_sorted":["cs.CE","physics.med-ph"],"title_canon_sha256":"c03ca17265fe13360053e3305a9b04d1f11cb2197a6ce453dae96f8bba6eb729","abstract_canon_sha256":"5623d315aa4a5ea4b95aff7fbb6ed1d9bdf469971daa7f46903695b2b1b9772a"},"schema_version":"1.0"},"canonical_sha256":"4fff05ced5ba90513688dabaa25305a0e78388eca6ba2991c94d48d1a026152a","source":{"kind":"arxiv","id":"1910.13200","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1910.13200","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"arxiv_version","alias_value":"1910.13200v1","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1910.13200","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_12","alias_value":"J77QLTWVXKIF","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_16","alias_value":"J77QLTWVXKIFCNUI","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_8","alias_value":"J77QLTWV","created_at":"2026-07-05T00:15:42Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2019:J77QLTWVXKIFCNUI3K5KEUYFUD","target":"record","payload":{"canonical_record":{"source":{"id":"1910.13200","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-10-29T11:16:25Z","cross_cats_sorted":["cs.CE","physics.med-ph"],"title_canon_sha256":"c03ca17265fe13360053e3305a9b04d1f11cb2197a6ce453dae96f8bba6eb729","abstract_canon_sha256":"5623d315aa4a5ea4b95aff7fbb6ed1d9bdf469971daa7f46903695b2b1b9772a"},"schema_version":"1.0"},"canonical_sha256":"4fff05ced5ba90513688dabaa25305a0e78388eca6ba2991c94d48d1a026152a","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T00:15:42.393372Z","signature_b64":"+oOHZMyDLRF0H80rwtxlq6bnF8OHNRMCmOChxdeMy7yxc+L4ifYvg1e9SpORBfVGPvwulivI1lZc0mWYdiRpDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4fff05ced5ba90513688dabaa25305a0e78388eca6ba2991c94d48d1a026152a","last_reissued_at":"2026-07-05T00:15:42.392981Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T00:15:42.392981Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1910.13200","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:15:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"oCM9xJPENurp/ApjhxCgqUytCdgBst4RdwMsSRL36ylfRI3FG0h6vNb9Ut0HZAT68XwIGpEmym1E8T+ZV1QdDg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-31T19:12:27.032043Z"},"content_sha256":"7fadd4d03e768af3df5a854f9c1f9d5111476e3a58647cb263b252d68c85bc6f","schema_version":"1.0","event_id":"sha256:7fadd4d03e768af3df5a854f9c1f9d5111476e3a58647cb263b252d68c85bc6f"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2019:J77QLTWVXKIFCNUI3K5KEUYFUD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Towards Quantifying Neurovascular Resilience","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cs.CE","physics.med-ph"],"primary_cat":"q-bio.QM","authors_text":"H. Rolf J\\\"ager, Maria A. Zuluaga, M. Jorge Cardoso, Parashkev Nachev, Rafael Rehwald, S\\'ebastien Ourselin, Stefano Moriconi","submitted_at":"2019-10-29T11:16:25Z","abstract_excerpt":"Whilst grading neurovascular abnormalities is critical for prompt surgical repair, no statistical markers are currently available for predicting the risk of adverse events, such as stroke, and the overall resilience of a network to vascular complications. The lack of compact, fast, and scalable simulations with network perturbations impedes the analysis of the vascular resilience to life-threatening conditions, surgical interventions and long-term follow-up. We introduce a graph-based approach for efficient simulations, which statistically estimates biomarkers from a series of perturbations on"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1910.13200","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/1910.13200/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T00:15:42Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"vlm/4Nt7y+c6WVz3LcZx+nvyTGNXY5oFyEwCXaGin9tYSwR/lzNEmIgx1iSlIATqyrcqStliMt2CSR+Hg4fODg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-07-31T19:12:27.032354Z"},"content_sha256":"5c3641ac0e3024a9c966aec3f5092c5c2dfd9a7fb9b091a85bac622b95743aa7","schema_version":"1.0","event_id":"sha256:5c3641ac0e3024a9c966aec3f5092c5c2dfd9a7fb9b091a85bac622b95743aa7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/bundle.json","state_url":"https://pith.science/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-07-31T19:12:27Z","links":{"resolver":"https://pith.science/pith/J77QLTWVXKIFCNUI3K5KEUYFUD","bundle":"https://pith.science/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/bundle.json","state":"https://pith.science/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/J77QLTWVXKIFCNUI3K5KEUYFUD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2019:J77QLTWVXKIFCNUI3K5KEUYFUD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"5623d315aa4a5ea4b95aff7fbb6ed1d9bdf469971daa7f46903695b2b1b9772a","cross_cats_sorted":["cs.CE","physics.med-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-10-29T11:16:25Z","title_canon_sha256":"c03ca17265fe13360053e3305a9b04d1f11cb2197a6ce453dae96f8bba6eb729"},"schema_version":"1.0","source":{"id":"1910.13200","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1910.13200","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"arxiv_version","alias_value":"1910.13200v1","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1910.13200","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_12","alias_value":"J77QLTWVXKIF","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_16","alias_value":"J77QLTWVXKIFCNUI","created_at":"2026-07-05T00:15:42Z"},{"alias_kind":"pith_short_8","alias_value":"J77QLTWV","created_at":"2026-07-05T00:15:42Z"}],"graph_snapshots":[{"event_id":"sha256:5c3641ac0e3024a9c966aec3f5092c5c2dfd9a7fb9b091a85bac622b95743aa7","target":"graph","created_at":"2026-07-05T00:15:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/1910.13200/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Whilst grading neurovascular abnormalities is critical for prompt surgical repair, no statistical markers are currently available for predicting the risk of adverse events, such as stroke, and the overall resilience of a network to vascular complications. The lack of compact, fast, and scalable simulations with network perturbations impedes the analysis of the vascular resilience to life-threatening conditions, surgical interventions and long-term follow-up. We introduce a graph-based approach for efficient simulations, which statistically estimates biomarkers from a series of perturbations on","authors_text":"H. Rolf J\\\"ager, Maria A. Zuluaga, M. Jorge Cardoso, Parashkev Nachev, Rafael Rehwald, S\\'ebastien Ourselin, Stefano Moriconi","cross_cats":["cs.CE","physics.med-ph"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-10-29T11:16:25Z","title":"Towards Quantifying Neurovascular Resilience"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1910.13200","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:7fadd4d03e768af3df5a854f9c1f9d5111476e3a58647cb263b252d68c85bc6f","target":"record","created_at":"2026-07-05T00:15:42Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"5623d315aa4a5ea4b95aff7fbb6ed1d9bdf469971daa7f46903695b2b1b9772a","cross_cats_sorted":["cs.CE","physics.med-ph"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2019-10-29T11:16:25Z","title_canon_sha256":"c03ca17265fe13360053e3305a9b04d1f11cb2197a6ce453dae96f8bba6eb729"},"schema_version":"1.0","source":{"id":"1910.13200","kind":"arxiv","version":1}},"canonical_sha256":"4fff05ced5ba90513688dabaa25305a0e78388eca6ba2991c94d48d1a026152a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4fff05ced5ba90513688dabaa25305a0e78388eca6ba2991c94d48d1a026152a","first_computed_at":"2026-07-05T00:15:42.392981Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T00:15:42.392981Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"+oOHZMyDLRF0H80rwtxlq6bnF8OHNRMCmOChxdeMy7yxc+L4ifYvg1e9SpORBfVGPvwulivI1lZc0mWYdiRpDg==","signature_status":"signed_v1","signed_at":"2026-07-05T00:15:42.393372Z","signed_message":"canonical_sha256_bytes"},"source_id":"1910.13200","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:7fadd4d03e768af3df5a854f9c1f9d5111476e3a58647cb263b252d68c85bc6f","sha256:5c3641ac0e3024a9c966aec3f5092c5c2dfd9a7fb9b091a85bac622b95743aa7"],"state_sha256":"0e3fca00a604d16531ad063bdaacb6ecab55b1852e3b59ea9d317d55ebb5c5ba"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"xntaohl6R6FG7YbE4Xs99j2uM/6cQmLDcF1VrEKhmeaf8FgG6i2nuYNUcFu2i2JYlHaREe+WFApBzW3wD3EbAQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-07-31T19:12:27.035279Z","bundle_sha256":"cb10034a919d598cf96aaf0156982e6d09a3e668d2f39ac63b1a3d6385637d87"}}