{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2018:JDJ7VFQNKZ44DJ3MKQWS74FHVF","short_pith_number":"pith:JDJ7VFQN","canonical_record":{"source":{"id":"1812.08748","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-12-20T18:27:04Z","cross_cats_sorted":[],"title_canon_sha256":"8b09a009a982c2712acf9f0e05206f329a2aa15e654f1d451af792f808367726","abstract_canon_sha256":"4c809b7c46543a9e972e3402fa5fffc4b7581bcb9a1e30439893d9682e7f96c3"},"schema_version":"1.0"},"canonical_sha256":"48d3fa960d5679c1a76c542d2ff0a7a953a6eda767be8bd75483a5e2402e85b7","source":{"kind":"arxiv","id":"1812.08748","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.08748","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"arxiv_version","alias_value":"1812.08748v2","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.08748","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"pith_short_12","alias_value":"JDJ7VFQNKZ44","created_at":"2026-05-18T12:32:31Z"},{"alias_kind":"pith_short_16","alias_value":"JDJ7VFQNKZ44DJ3M","created_at":"2026-05-18T12:32:31Z"},{"alias_kind":"pith_short_8","alias_value":"JDJ7VFQN","created_at":"2026-05-18T12:32:31Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2018:JDJ7VFQNKZ44DJ3MKQWS74FHVF","target":"record","payload":{"canonical_record":{"source":{"id":"1812.08748","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-12-20T18:27:04Z","cross_cats_sorted":[],"title_canon_sha256":"8b09a009a982c2712acf9f0e05206f329a2aa15e654f1d451af792f808367726","abstract_canon_sha256":"4c809b7c46543a9e972e3402fa5fffc4b7581bcb9a1e30439893d9682e7f96c3"},"schema_version":"1.0"},"canonical_sha256":"48d3fa960d5679c1a76c542d2ff0a7a953a6eda767be8bd75483a5e2402e85b7","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-17T23:47:26.915195Z","signature_b64":"5gHXUUvIEbMJq2SUrvTT3M2cdGl3NPGYVxP6jzs756v2WX1JzvVjJyDqQOt/IMR6j8O2BvhkzPIu3fgtA2YrDw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"48d3fa960d5679c1a76c542d2ff0a7a953a6eda767be8bd75483a5e2402e85b7","last_reissued_at":"2026-05-17T23:47:26.914693Z","signature_status":"signed_v1","first_computed_at":"2026-05-17T23:47:26.914693Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1812.08748","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:47:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"j0CPVmoWPb7b7WUwg4faZ0sUAmyG0SikAaMdnCFbAgLhFjymya9VQj6yIGR2qSF2JXzPZ5iSPrvdxZbPTftPBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T07:09:21.523134Z"},"content_sha256":"6196c6abbe184e198c86e8b88b171396168dab68df3bbc840188a49c5ad6e477","schema_version":"1.0","event_id":"sha256:6196c6abbe184e198c86e8b88b171396168dab68df3bbc840188a49c5ad6e477"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2018:JDJ7VFQNKZ44DJ3MKQWS74FHVF","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Absolute diffusion measurements of active enzyme solutions by NMR","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"physics.chem-ph","authors_text":"G\\\"unter Majer, Jan-Philipp G\\\"unther, Peer Fischer","submitted_at":"2018-12-20T18:27:04Z","abstract_excerpt":"The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their substrate or inhibitor. In this context, major importance is given to the enzyme fructose-bisphosphate aldolase, for which enhanced diffusion has been reported even though the catalysed reaction is endothermic. Additionally, enhanced diffusion of tracer "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.08748","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-17T23:47:26Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3QxXqe7CIKwGOgc02k9VWYF0PbmCzFI8G069qwIQiimJLGrravUTUyHcP6HQQbCrD1vPW8QcMAaSkrV0fpGDAA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-04T07:09:21.523842Z"},"content_sha256":"0a9ce7b8997139c3cc4cdf3fa631c2224b7f9bad763d21ad7e1d477c5874f9ad","schema_version":"1.0","event_id":"sha256:0a9ce7b8997139c3cc4cdf3fa631c2224b7f9bad763d21ad7e1d477c5874f9ad"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/bundle.json","state_url":"https://pith.science/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-04T07:09:21Z","links":{"resolver":"https://pith.science/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF","bundle":"https://pith.science/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/bundle.json","state":"https://pith.science/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JDJ7VFQNKZ44DJ3MKQWS74FHVF/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2018:JDJ7VFQNKZ44DJ3MKQWS74FHVF","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4c809b7c46543a9e972e3402fa5fffc4b7581bcb9a1e30439893d9682e7f96c3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-12-20T18:27:04Z","title_canon_sha256":"8b09a009a982c2712acf9f0e05206f329a2aa15e654f1d451af792f808367726"},"schema_version":"1.0","source":{"id":"1812.08748","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1812.08748","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"arxiv_version","alias_value":"1812.08748v2","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1812.08748","created_at":"2026-05-17T23:47:26Z"},{"alias_kind":"pith_short_12","alias_value":"JDJ7VFQNKZ44","created_at":"2026-05-18T12:32:31Z"},{"alias_kind":"pith_short_16","alias_value":"JDJ7VFQNKZ44DJ3M","created_at":"2026-05-18T12:32:31Z"},{"alias_kind":"pith_short_8","alias_value":"JDJ7VFQN","created_at":"2026-05-18T12:32:31Z"}],"graph_snapshots":[{"event_id":"sha256:0a9ce7b8997139c3cc4cdf3fa631c2224b7f9bad763d21ad7e1d477c5874f9ad","target":"graph","created_at":"2026-05-17T23:47:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"The diffusion of enzymes is of fundamental importance for many biochemical processes. Enhanced or directed enzyme diffusion can alter the accessibility of substrates and the organization of enzymes within cells. Several studies based on fluorescence correlation spectroscopy (FCS) report enhanced diffusion of enzymes upon interaction with their substrate or inhibitor. In this context, major importance is given to the enzyme fructose-bisphosphate aldolase, for which enhanced diffusion has been reported even though the catalysed reaction is endothermic. Additionally, enhanced diffusion of tracer ","authors_text":"G\\\"unter Majer, Jan-Philipp G\\\"unther, Peer Fischer","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-12-20T18:27:04Z","title":"Absolute diffusion measurements of active enzyme solutions by NMR"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1812.08748","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:6196c6abbe184e198c86e8b88b171396168dab68df3bbc840188a49c5ad6e477","target":"record","created_at":"2026-05-17T23:47:26Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4c809b7c46543a9e972e3402fa5fffc4b7581bcb9a1e30439893d9682e7f96c3","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.chem-ph","submitted_at":"2018-12-20T18:27:04Z","title_canon_sha256":"8b09a009a982c2712acf9f0e05206f329a2aa15e654f1d451af792f808367726"},"schema_version":"1.0","source":{"id":"1812.08748","kind":"arxiv","version":2}},"canonical_sha256":"48d3fa960d5679c1a76c542d2ff0a7a953a6eda767be8bd75483a5e2402e85b7","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"48d3fa960d5679c1a76c542d2ff0a7a953a6eda767be8bd75483a5e2402e85b7","first_computed_at":"2026-05-17T23:47:26.914693Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-17T23:47:26.914693Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"5gHXUUvIEbMJq2SUrvTT3M2cdGl3NPGYVxP6jzs756v2WX1JzvVjJyDqQOt/IMR6j8O2BvhkzPIu3fgtA2YrDw==","signature_status":"signed_v1","signed_at":"2026-05-17T23:47:26.915195Z","signed_message":"canonical_sha256_bytes"},"source_id":"1812.08748","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:6196c6abbe184e198c86e8b88b171396168dab68df3bbc840188a49c5ad6e477","sha256:0a9ce7b8997139c3cc4cdf3fa631c2224b7f9bad763d21ad7e1d477c5874f9ad"],"state_sha256":"e08e050fc3f817960845066b1bd28a821ae0e33bff5fa48e0195bac430ca8951"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"KaZewst9rwosUnoo/Qx81qotqz47U5F7KnCbs6dW0AMLJFR8iRkCkhOEXeE1jg26dIufnZffJqDGmsGx+/HGDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-04T07:09:21.528123Z","bundle_sha256":"b2a106535eb56592e407e85244c3e9fc66c3156394048a2f461615aa830e1973"}}