{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:JDRGCYRTTXIXRQSFOS4X35XFPC","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"902230ceff7df172a65aa8b7d334e153c944ca88ed2109d1a2eb529ed33fdbaa","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-04-11T12:14:07Z","title_canon_sha256":"994de9dffe59c5b03cf32954caeda13661ff97c60930f3bc0a65e2748dcbb757"},"schema_version":"1.0","source":{"id":"1604.02909","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1604.02909","created_at":"2026-05-18T01:17:21Z"},{"alias_kind":"arxiv_version","alias_value":"1604.02909v1","created_at":"2026-05-18T01:17:21Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1604.02909","created_at":"2026-05-18T01:17:21Z"},{"alias_kind":"pith_short_12","alias_value":"JDRGCYRTTXIX","created_at":"2026-05-18T12:30:25Z"},{"alias_kind":"pith_short_16","alias_value":"JDRGCYRTTXIXRQSF","created_at":"2026-05-18T12:30:25Z"},{"alias_kind":"pith_short_8","alias_value":"JDRGCYRT","created_at":"2026-05-18T12:30:25Z"}],"graph_snapshots":[{"event_id":"sha256:17bc6d63b94ac3f28cdbb215271f0d9f34cb643538e6c0b4ebd86984381297d8","target":"graph","created_at":"2026-05-18T01:17:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In cancer treatment, chemotherapy is administered according a constant schedule. The chronotherapy approach, considering chronobiological drug delivery, adapts the chemotherapy profile to the circadian rhythms of the human organism. This reduces toxicity effects and at the same time enhances efficiency of chemotherapy. To personalize cancer treatment, chemotherapy profiles have to be further adapted to individual patients. Therefore, we present a new model to represent cycle phenomena in circadian rhythms. The model enables a more precise modelling of the underlying circadian rhythms. In compa","authors_text":"Alexandre Arbaud, Benjamin Schott, Francis L\\'evi, Johannes Stegmaier, Markus Reischl, Ralf Mikut","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-04-11T12:14:07Z","title":"Robust Individual Circadian Parameter Estimation for Biosignal-based Personalisation of Cancer Chronotherapy"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1604.02909","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:f2c5e64533a91143aa8994ca2ad33b61468052bc87c730621e9ff851203d4944","target":"record","created_at":"2026-05-18T01:17:21Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"902230ceff7df172a65aa8b7d334e153c944ca88ed2109d1a2eb529ed33fdbaa","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2016-04-11T12:14:07Z","title_canon_sha256":"994de9dffe59c5b03cf32954caeda13661ff97c60930f3bc0a65e2748dcbb757"},"schema_version":"1.0","source":{"id":"1604.02909","kind":"arxiv","version":1}},"canonical_sha256":"48e26162339dd178c24574b97df6e5788ab1c507af7c40c08e8efddae39a7385","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"48e26162339dd178c24574b97df6e5788ab1c507af7c40c08e8efddae39a7385","first_computed_at":"2026-05-18T01:17:21.880551Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:17:21.880551Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"/q3EAj7T/ypzzNvFmCVGbzJuVukxIfHanyxmGfOhS37axYMFXcOlLVBvBeMYa3UgIBd+RDMCwjHTx8OJxF/UCg==","signature_status":"signed_v1","signed_at":"2026-05-18T01:17:21.880974Z","signed_message":"canonical_sha256_bytes"},"source_id":"1604.02909","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:f2c5e64533a91143aa8994ca2ad33b61468052bc87c730621e9ff851203d4944","sha256:17bc6d63b94ac3f28cdbb215271f0d9f34cb643538e6c0b4ebd86984381297d8"],"state_sha256":"7b5028f98634c0e6ba9c119dfa217084090e58ebb53e5d8fbc3e12a4f6dd5819"}