{"record_type":"pith_number_record","schema_url":"https://pith.science/schemas/pith-number/v1.json","pith_number":"pith:2001:JDZFNE3V6WPGMD62FXFAJOGIEX","short_pith_number":"pith:JDZFNE3V","schema_version":"1.0","canonical_sha256":"48f2569375f59e660fda2dca04b8c825ee94a54532011b00cce85c3f84eca1d7","source":{"kind":"arxiv","id":"physics/0109014","version":2},"attestation_state":"computed","paper":{"title":"Modeling the effects of tetanus vaccination on chronically infected HIV patients","license":"","headline":"","cross_cats":["q-bio.CB","q-bio.PE"],"primary_cat":"physics.bio-ph","authors_text":"Alan S. Perelson (Biophysics, Laura E. Jones, Los Alamos National Laboratory), Theoretical Biology","submitted_at":"2001-09-05T21:47:12Z","abstract_excerpt":"T-cell activation plays a critical role in the initiation and propagation of HIV-1 infection and yet transient activation of the immune system is a normal response to immunization. In this study we extend a simple of model of HIV infection to include T cell activation by vaccination. We then show that the model can reproduce many but not all of the features of the post-tetanus immunization rise in viral load observed and reported on by Stanley et al., [N. Engl. J. Med., 334:1222--1230 (1996)]. Amplitudes and approximate timing of post-immunization maximum viremia were matched in nine of twelve"},"verification_status":{"content_addressed":true,"pith_receipt":true,"author_attested":false,"weak_author_claims":0,"strong_author_claims":0,"externally_anchored":false,"storage_verified":false,"citation_signatures":0,"replication_records":0,"graph_snapshot":true,"references_resolved":false,"formal_links_present":false},"canonical_record":{"source":{"id":"physics/0109014","kind":"arxiv","version":2},"metadata":{"license":"","primary_cat":"physics.bio-ph","submitted_at":"2001-09-05T21:47:12Z","cross_cats_sorted":["q-bio.CB","q-bio.PE"],"title_canon_sha256":"a33d35b74bd79a4d12257bce44b439caec6136ad7943a3c1fec8a1feca6db406","abstract_canon_sha256":"a173b3e5051d5af023f8a25d12935a91f0fd47cceaefb4e11fb892c47d2ddfea"},"schema_version":"1.0"},"receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T03:40:26.491067Z","signature_b64":"k5cvH6IJja6pXLqGgFJ5fC+ioCvzaCjYwy1z7CQWPnDOvHyWYX8jAjkpIxeIu0CJqqmteVcvGrvipg9S6ZX0Cg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"48f2569375f59e660fda2dca04b8c825ee94a54532011b00cce85c3f84eca1d7","last_reissued_at":"2026-05-18T03:40:26.490508Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T03:40:26.490508Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"graph_snapshot":{"paper":{"title":"Modeling the effects of tetanus vaccination on chronically infected HIV patients","license":"","headline":"","cross_cats":["q-bio.CB","q-bio.PE"],"primary_cat":"physics.bio-ph","authors_text":"Alan S. Perelson (Biophysics, Laura E. Jones, Los Alamos National Laboratory), Theoretical Biology","submitted_at":"2001-09-05T21:47:12Z","abstract_excerpt":"T-cell activation plays a critical role in the initiation and propagation of HIV-1 infection and yet transient activation of the immune system is a normal response to immunization. In this study we extend a simple of model of HIV infection to include T cell activation by vaccination. We then show that the model can reproduce many but not all of the features of the post-tetanus immunization rise in viral load observed and reported on by Stanley et al., [N. Engl. J. Med., 334:1222--1230 (1996)]. Amplitudes and approximate timing of post-immunization maximum viremia were matched in nine of twelve"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"physics/0109014","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"aliases":[{"alias_kind":"arxiv","alias_value":"physics/0109014","created_at":"2026-05-18T03:40:26.490596+00:00"},{"alias_kind":"arxiv_version","alias_value":"physics/0109014v2","created_at":"2026-05-18T03:40:26.490596+00:00"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.physics/0109014","created_at":"2026-05-18T03:40:26.490596+00:00"},{"alias_kind":"pith_short_12","alias_value":"JDZFNE3V6WPG","created_at":"2026-05-18T12:25:50.254431+00:00"},{"alias_kind":"pith_short_16","alias_value":"JDZFNE3V6WPGMD62","created_at":"2026-05-18T12:25:50.254431+00:00"},{"alias_kind":"pith_short_8","alias_value":"JDZFNE3V","created_at":"2026-05-18T12:25:50.254431+00:00"}],"events":[],"event_summary":{},"paper_claims":[],"inbound_citations":{"count":0,"internal_anchor_count":0,"sample":[]},"formal_canon":{"evidence_count":0,"sample":[],"anchors":[]},"links":{"html":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX","json":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX.json","graph_json":"https://pith.science/api/pith-number/JDZFNE3V6WPGMD62FXFAJOGIEX/graph.json","events_json":"https://pith.science/api/pith-number/JDZFNE3V6WPGMD62FXFAJOGIEX/events.json","paper":"https://pith.science/paper/JDZFNE3V"},"agent_actions":{"view_html":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX","download_json":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX.json","view_paper":"https://pith.science/paper/JDZFNE3V","resolve_alias":"https://pith.science/api/pith-number/resolve?arxiv=physics/0109014&json=true","fetch_graph":"https://pith.science/api/pith-number/JDZFNE3V6WPGMD62FXFAJOGIEX/graph.json","fetch_events":"https://pith.science/api/pith-number/JDZFNE3V6WPGMD62FXFAJOGIEX/events.json","actions":{"anchor_timestamp":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX/action/timestamp_anchor","attest_storage":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX/action/storage_attestation","attest_author":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX/action/author_attestation","sign_citation":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX/action/citation_signature","submit_replication":"https://pith.science/pith/JDZFNE3V6WPGMD62FXFAJOGIEX/action/replication_record"}},"created_at":"2026-05-18T03:40:26.490596+00:00","updated_at":"2026-05-18T03:40:26.490596+00:00"}