{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:JEZK6IX5LJNLX5UFPEGMYHSWJD","short_pith_number":"pith:JEZK6IX5","canonical_record":{"source":{"id":"1409.2584","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-09-09T03:36:46Z","cross_cats_sorted":[],"title_canon_sha256":"c1e6cc1c0d2c6338d264855cb6bd6058f7f856e1646f024533c3deab7f81eb36","abstract_canon_sha256":"d29117c470eb1c1ecdb85881efe013327f51038c1b20f407041b27facdf24898"},"schema_version":"1.0"},"canonical_sha256":"4932af22fd5a5abbf685790ccc1e5648da11e73933c30ae2b0728a6baeed407c","source":{"kind":"arxiv","id":"1409.2584","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1409.2584","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"arxiv_version","alias_value":"1409.2584v1","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1409.2584","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"pith_short_12","alias_value":"JEZK6IX5LJNL","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"JEZK6IX5LJNLX5UF","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"JEZK6IX5","created_at":"2026-05-18T12:28:33Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:JEZK6IX5LJNLX5UFPEGMYHSWJD","target":"record","payload":{"canonical_record":{"source":{"id":"1409.2584","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-09-09T03:36:46Z","cross_cats_sorted":[],"title_canon_sha256":"c1e6cc1c0d2c6338d264855cb6bd6058f7f856e1646f024533c3deab7f81eb36","abstract_canon_sha256":"d29117c470eb1c1ecdb85881efe013327f51038c1b20f407041b27facdf24898"},"schema_version":"1.0"},"canonical_sha256":"4932af22fd5a5abbf685790ccc1e5648da11e73933c30ae2b0728a6baeed407c","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:43:10.237452Z","signature_b64":"nYi2hiTJSENKVNrgYN7HCrSeKpOQjic7uhKE6OZmcRvqZuJep7QMn8MFeCnuYJl2hDbox6/6wteUiKrayoNaCw==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4932af22fd5a5abbf685790ccc1e5648da11e73933c30ae2b0728a6baeed407c","last_reissued_at":"2026-05-18T02:43:10.236929Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:43:10.236929Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1409.2584","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:43:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"O3vYEKNjUgpVPKXl+4QOE1Sw1V8ReknUpdfM/6b9e/FVK0VcDLPnftW142Xpq2Lrykbea75+G/n6rWyciOs8Dg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T09:02:04.342793Z"},"content_sha256":"436c3776be48220f4b9403f017f23a067264ee4baabe86244c1cae4e3949561d","schema_version":"1.0","event_id":"sha256:436c3776be48220f4b9403f017f23a067264ee4baabe86244c1cae4e3949561d"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:JEZK6IX5LJNLX5UFPEGMYHSWJD","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Conformational selection in protein binding and function","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.BM","authors_text":"Fabian Paul, Thomas R. Weikl","submitted_at":"2014-09-09T03:36:46Z","abstract_excerpt":"Protein binding and function often involves conformational changes. Advanced NMR experiments indicate that these conformational changes can occur in the absence of ligand molecules (or with bound ligands), and that the ligands may 'select' protein conformations for binding (or unbinding). In this review, we argue that this conformational selection requires transition times for ligand binding and unbinding that are small compared to the dwell times of proteins in different conformations, which is plausible for small ligand molecules. Such a separation of timescales leads to a decoupling and tem"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.2584","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:43:10Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"03dvXzqcbU45p+iuaeze6tpFRqdB+ryffcIqHp+Jf0U31o4onoSF43kzQqnU1TjJk83wcrP47wbXKONYOr+DAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-20T09:02:04.343138Z"},"content_sha256":"31998cf9c5d60022041b928149ecff18eb42a683e85110be45cf68599abd45b7","schema_version":"1.0","event_id":"sha256:31998cf9c5d60022041b928149ecff18eb42a683e85110be45cf68599abd45b7"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/bundle.json","state_url":"https://pith.science/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-20T09:02:04Z","links":{"resolver":"https://pith.science/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD","bundle":"https://pith.science/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/bundle.json","state":"https://pith.science/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JEZK6IX5LJNLX5UFPEGMYHSWJD/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:JEZK6IX5LJNLX5UFPEGMYHSWJD","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"d29117c470eb1c1ecdb85881efe013327f51038c1b20f407041b27facdf24898","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-09-09T03:36:46Z","title_canon_sha256":"c1e6cc1c0d2c6338d264855cb6bd6058f7f856e1646f024533c3deab7f81eb36"},"schema_version":"1.0","source":{"id":"1409.2584","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1409.2584","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"arxiv_version","alias_value":"1409.2584v1","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1409.2584","created_at":"2026-05-18T02:43:10Z"},{"alias_kind":"pith_short_12","alias_value":"JEZK6IX5LJNL","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"JEZK6IX5LJNLX5UF","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"JEZK6IX5","created_at":"2026-05-18T12:28:33Z"}],"graph_snapshots":[{"event_id":"sha256:31998cf9c5d60022041b928149ecff18eb42a683e85110be45cf68599abd45b7","target":"graph","created_at":"2026-05-18T02:43:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Protein binding and function often involves conformational changes. Advanced NMR experiments indicate that these conformational changes can occur in the absence of ligand molecules (or with bound ligands), and that the ligands may 'select' protein conformations for binding (or unbinding). In this review, we argue that this conformational selection requires transition times for ligand binding and unbinding that are small compared to the dwell times of proteins in different conformations, which is plausible for small ligand molecules. Such a separation of timescales leads to a decoupling and tem","authors_text":"Fabian Paul, Thomas R. Weikl","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-09-09T03:36:46Z","title":"Conformational selection in protein binding and function"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1409.2584","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:436c3776be48220f4b9403f017f23a067264ee4baabe86244c1cae4e3949561d","target":"record","created_at":"2026-05-18T02:43:10Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"d29117c470eb1c1ecdb85881efe013327f51038c1b20f407041b27facdf24898","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.BM","submitted_at":"2014-09-09T03:36:46Z","title_canon_sha256":"c1e6cc1c0d2c6338d264855cb6bd6058f7f856e1646f024533c3deab7f81eb36"},"schema_version":"1.0","source":{"id":"1409.2584","kind":"arxiv","version":1}},"canonical_sha256":"4932af22fd5a5abbf685790ccc1e5648da11e73933c30ae2b0728a6baeed407c","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4932af22fd5a5abbf685790ccc1e5648da11e73933c30ae2b0728a6baeed407c","first_computed_at":"2026-05-18T02:43:10.236929Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:43:10.236929Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"nYi2hiTJSENKVNrgYN7HCrSeKpOQjic7uhKE6OZmcRvqZuJep7QMn8MFeCnuYJl2hDbox6/6wteUiKrayoNaCw==","signature_status":"signed_v1","signed_at":"2026-05-18T02:43:10.237452Z","signed_message":"canonical_sha256_bytes"},"source_id":"1409.2584","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:436c3776be48220f4b9403f017f23a067264ee4baabe86244c1cae4e3949561d","sha256:31998cf9c5d60022041b928149ecff18eb42a683e85110be45cf68599abd45b7"],"state_sha256":"d405b84dd9446febe02ae7996d38aba65a357e057b979d6e2f6824564723362b"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"3ingG3PaUzGUw4j1+qA4Y5WZ6nA0r5mYyBRe4UzyDSpJhhQ0d6LX1YyIL527/3eFimokRkRhCqYAj7uIWciBDg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-20T09:02:04.345154Z","bundle_sha256":"255daa7675d65e384c4f66bfbe4ed05d37243ff54962ca755104b513d6414165"}}