{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2014:JHND5JLDK35PQQ5555F4XW2DR6","short_pith_number":"pith:JHND5JLD","canonical_record":{"source":{"id":"1402.6151","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-02-25T12:33:58Z","cross_cats_sorted":["q-bio.PE","stat.AP"],"title_canon_sha256":"c939711258830a0c25a0e6573dcbb9a10ed3973df77344c12d22e32c6702d826","abstract_canon_sha256":"7850a443a2b7e804f068db0cc1be1bc2019a840ef66f6ec67994280ce0fb95db"},"schema_version":"1.0"},"canonical_sha256":"49da3ea56356faf843bdef4bcbdb438fb7a72047a91445b122270bc45b62ccdb","source":{"kind":"arxiv","id":"1402.6151","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1402.6151","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"arxiv_version","alias_value":"1402.6151v1","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1402.6151","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"pith_short_12","alias_value":"JHND5JLDK35P","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"JHND5JLDK35PQQ55","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"JHND5JLD","created_at":"2026-05-18T12:28:33Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2014:JHND5JLDK35PQQ5555F4XW2DR6","target":"record","payload":{"canonical_record":{"source":{"id":"1402.6151","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-02-25T12:33:58Z","cross_cats_sorted":["q-bio.PE","stat.AP"],"title_canon_sha256":"c939711258830a0c25a0e6573dcbb9a10ed3973df77344c12d22e32c6702d826","abstract_canon_sha256":"7850a443a2b7e804f068db0cc1be1bc2019a840ef66f6ec67994280ce0fb95db"},"schema_version":"1.0"},"canonical_sha256":"49da3ea56356faf843bdef4bcbdb438fb7a72047a91445b122270bc45b62ccdb","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T02:57:51.489341Z","signature_b64":"HPaACQCbwMEt1031mPooiW9gj+PE4euJlR+I63O3G28D3r+Wr0tZXKGopCT9hmcVZh9xE5jfFSrIKzXg2BXUCA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"49da3ea56356faf843bdef4bcbdb438fb7a72047a91445b122270bc45b62ccdb","last_reissued_at":"2026-05-18T02:57:51.488808Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T02:57:51.488808Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1402.6151","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:57:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"R+nEjezAjwELQz9rV97fFgzvbc8Ik1KF6tAw6YwaW4dE/GTkhX8ge56y4uC3zhZ4wmHjdzX1RngpJIaPDqp0Cg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T22:06:12.651843Z"},"content_sha256":"448bdeb78fe30ecc9a1ed44d0d9572236e189e52ca87592464ab117412a10839","schema_version":"1.0","event_id":"sha256:448bdeb78fe30ecc9a1ed44d0d9572236e189e52ca87592464ab117412a10839"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2014:JHND5JLDK35PQQ5555F4XW2DR6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Approaching allelic probabilities and Genome-Wide Association Studies from beta distributions","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.PE","stat.AP"],"primary_cat":"q-bio.GN","authors_text":"Agust\\'in Ruiz, Angel del R\\'io, Antonio Gonz\\'alez-P\\'erez, Javier Gay\\'an, Jos\\'e A. Garc\\'ia, Jos\\'e Santiago Garc\\'ia-Cremades, Manuel Ruiz-Mar\\'in, O. Sotolongo-Grau","submitted_at":"2014-02-25T12:33:58Z","abstract_excerpt":"In this paper we have proposed a model for the distribution of allelic probabilities for generating populations as reliably as possible. Our objective was to develop such a model which would allow simulating allelic probabilities with different observed truncation and de- gree of noise. In addition, we have also introduced here a complete new approach to analyze a genome-wide association study (GWAS) dataset, starting from a new test of association with a statistical distribution and two effect sizes of each genotype. The new methodologi- cal approach was applied to a real data set together wi"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1402.6151","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T02:57:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"a/mMYVM7fi05keiYM7ebLhu3QCsXNvyoHG29LKxzJadg/Jyq/evxcT3g1X5TIUg1MYlesYtHA6GZFAmD3PSEAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-28T22:06:12.652575Z"},"content_sha256":"c03e7baa0a52890084b781c889c845de751af6baafb67d38130e5b0b669c74b0","schema_version":"1.0","event_id":"sha256:c03e7baa0a52890084b781c889c845de751af6baafb67d38130e5b0b669c74b0"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JHND5JLDK35PQQ5555F4XW2DR6/bundle.json","state_url":"https://pith.science/pith/JHND5JLDK35PQQ5555F4XW2DR6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JHND5JLDK35PQQ5555F4XW2DR6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-28T22:06:12Z","links":{"resolver":"https://pith.science/pith/JHND5JLDK35PQQ5555F4XW2DR6","bundle":"https://pith.science/pith/JHND5JLDK35PQQ5555F4XW2DR6/bundle.json","state":"https://pith.science/pith/JHND5JLDK35PQQ5555F4XW2DR6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JHND5JLDK35PQQ5555F4XW2DR6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2014:JHND5JLDK35PQQ5555F4XW2DR6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"7850a443a2b7e804f068db0cc1be1bc2019a840ef66f6ec67994280ce0fb95db","cross_cats_sorted":["q-bio.PE","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-02-25T12:33:58Z","title_canon_sha256":"c939711258830a0c25a0e6573dcbb9a10ed3973df77344c12d22e32c6702d826"},"schema_version":"1.0","source":{"id":"1402.6151","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1402.6151","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"arxiv_version","alias_value":"1402.6151v1","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1402.6151","created_at":"2026-05-18T02:57:51Z"},{"alias_kind":"pith_short_12","alias_value":"JHND5JLDK35P","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_16","alias_value":"JHND5JLDK35PQQ55","created_at":"2026-05-18T12:28:33Z"},{"alias_kind":"pith_short_8","alias_value":"JHND5JLD","created_at":"2026-05-18T12:28:33Z"}],"graph_snapshots":[{"event_id":"sha256:c03e7baa0a52890084b781c889c845de751af6baafb67d38130e5b0b669c74b0","target":"graph","created_at":"2026-05-18T02:57:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In this paper we have proposed a model for the distribution of allelic probabilities for generating populations as reliably as possible. Our objective was to develop such a model which would allow simulating allelic probabilities with different observed truncation and de- gree of noise. In addition, we have also introduced here a complete new approach to analyze a genome-wide association study (GWAS) dataset, starting from a new test of association with a statistical distribution and two effect sizes of each genotype. The new methodologi- cal approach was applied to a real data set together wi","authors_text":"Agust\\'in Ruiz, Angel del R\\'io, Antonio Gonz\\'alez-P\\'erez, Javier Gay\\'an, Jos\\'e A. Garc\\'ia, Jos\\'e Santiago Garc\\'ia-Cremades, Manuel Ruiz-Mar\\'in, O. Sotolongo-Grau","cross_cats":["q-bio.PE","stat.AP"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-02-25T12:33:58Z","title":"Approaching allelic probabilities and Genome-Wide Association Studies from beta distributions"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1402.6151","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:448bdeb78fe30ecc9a1ed44d0d9572236e189e52ca87592464ab117412a10839","target":"record","created_at":"2026-05-18T02:57:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"7850a443a2b7e804f068db0cc1be1bc2019a840ef66f6ec67994280ce0fb95db","cross_cats_sorted":["q-bio.PE","stat.AP"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.GN","submitted_at":"2014-02-25T12:33:58Z","title_canon_sha256":"c939711258830a0c25a0e6573dcbb9a10ed3973df77344c12d22e32c6702d826"},"schema_version":"1.0","source":{"id":"1402.6151","kind":"arxiv","version":1}},"canonical_sha256":"49da3ea56356faf843bdef4bcbdb438fb7a72047a91445b122270bc45b62ccdb","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"49da3ea56356faf843bdef4bcbdb438fb7a72047a91445b122270bc45b62ccdb","first_computed_at":"2026-05-18T02:57:51.488808Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T02:57:51.488808Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"HPaACQCbwMEt1031mPooiW9gj+PE4euJlR+I63O3G28D3r+Wr0tZXKGopCT9hmcVZh9xE5jfFSrIKzXg2BXUCA==","signature_status":"signed_v1","signed_at":"2026-05-18T02:57:51.489341Z","signed_message":"canonical_sha256_bytes"},"source_id":"1402.6151","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:448bdeb78fe30ecc9a1ed44d0d9572236e189e52ca87592464ab117412a10839","sha256:c03e7baa0a52890084b781c889c845de751af6baafb67d38130e5b0b669c74b0"],"state_sha256":"347c599f4fdbc73048d5a550ab063163529512854bf336d241a9f90ee7c54c1a"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"mmXsEQ5nYAsGbPIGVW0jVGDNWrj2K/elUI/AZi3WtXuX/ya7CazM519x9e2mGW1VEfLBwqzMkgNbym9htIsXAg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-28T22:06:12.656237Z","bundle_sha256":"8efcf69f5f241b71b0cfbe25d643eff5ad9a2febe72dfbcac46de962e401ca05"}}