{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:JJ6GKVSGYKYUDIZJEIPFIZKKE2","short_pith_number":"pith:JJ6GKVSG","canonical_record":{"source":{"id":"1512.05896","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-18T10:49:35Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"a6e3ba1e958ff2456d8dddf2b3dab93393d9b9f893b68f00890b62ff775ba195","abstract_canon_sha256":"4d08da1dedff170998663e9a88d4aa7649d26d6eb2110b72e681fe59766f116f"},"schema_version":"1.0"},"canonical_sha256":"4a7c655646c2b141a329221e54654a269a20d0929817d5bc14c33e09fb7c6dd6","source":{"kind":"arxiv","id":"1512.05896","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.05896","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"arxiv_version","alias_value":"1512.05896v1","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.05896","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"pith_short_12","alias_value":"JJ6GKVSGYKYU","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_16","alias_value":"JJ6GKVSGYKYUDIZJ","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_8","alias_value":"JJ6GKVSG","created_at":"2026-05-18T12:29:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:JJ6GKVSGYKYUDIZJEIPFIZKKE2","target":"record","payload":{"canonical_record":{"source":{"id":"1512.05896","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-18T10:49:35Z","cross_cats_sorted":["q-bio.CB"],"title_canon_sha256":"a6e3ba1e958ff2456d8dddf2b3dab93393d9b9f893b68f00890b62ff775ba195","abstract_canon_sha256":"4d08da1dedff170998663e9a88d4aa7649d26d6eb2110b72e681fe59766f116f"},"schema_version":"1.0"},"canonical_sha256":"4a7c655646c2b141a329221e54654a269a20d0929817d5bc14c33e09fb7c6dd6","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:18:38.997206Z","signature_b64":"EEJOv1vdYeMmtVNESFYAxPBwzN9XyqJ5jXrujvQBEQLKJA5StxyV6wr/6yqHkfsoXJPu3AkDCHZzeEBLaN97BA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4a7c655646c2b141a329221e54654a269a20d0929817d5bc14c33e09fb7c6dd6","last_reissued_at":"2026-05-18T01:18:38.996717Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:18:38.996717Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1512.05896","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:18:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"2jkQQ9123ADUnMT1tApYRukB0Px+DUn7kYJ3cvJKtgN0mnPJw4suYvJOOXUTVWph3OrPBUbetqV/wfz+hcjJBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T15:13:49.934528Z"},"content_sha256":"186ace4cdbba8bb44675eee02274b060e9ae983892a7fe43e4ef22374bccc4bc","schema_version":"1.0","event_id":"sha256:186ace4cdbba8bb44675eee02274b060e9ae983892a7fe43e4ef22374bccc4bc"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:JJ6GKVSGYKYUDIZJEIPFIZKKE2","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"An interplay of migratory and division forces as a generic mechanism for stem cell patterns","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["q-bio.CB"],"primary_cat":"physics.bio-ph","authors_text":"Alice Coucke, Edouard Hannezo, Jean-Fran\\c{c}ois Joanny","submitted_at":"2015-12-18T10:49:35Z","abstract_excerpt":"In many adult tissues, stem cells and differentiated cells are not homogeneously distributed : stem cells are arranged in periodic \"niches\", and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.05896","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:18:38Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"dO61o8nC3TcjtocCozQ9h6Ivx/S1ZSHDzC4h2hRRI77/tY8a388JGRxO9gPpenM/pQVhtkIJfKfj/KgxNUfBAQ==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-05-31T15:13:49.935145Z"},"content_sha256":"05afb01517dab4903a2e618aa8560369f430efb90d79365b69bfada2d32d4721","schema_version":"1.0","event_id":"sha256:05afb01517dab4903a2e618aa8560369f430efb90d79365b69bfada2d32d4721"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/bundle.json","state_url":"https://pith.science/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-05-31T15:13:49Z","links":{"resolver":"https://pith.science/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2","bundle":"https://pith.science/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/bundle.json","state":"https://pith.science/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JJ6GKVSGYKYUDIZJEIPFIZKKE2/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:JJ6GKVSGYKYUDIZJEIPFIZKKE2","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"4d08da1dedff170998663e9a88d4aa7649d26d6eb2110b72e681fe59766f116f","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-18T10:49:35Z","title_canon_sha256":"a6e3ba1e958ff2456d8dddf2b3dab93393d9b9f893b68f00890b62ff775ba195"},"schema_version":"1.0","source":{"id":"1512.05896","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1512.05896","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"arxiv_version","alias_value":"1512.05896v1","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1512.05896","created_at":"2026-05-18T01:18:38Z"},{"alias_kind":"pith_short_12","alias_value":"JJ6GKVSGYKYU","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_16","alias_value":"JJ6GKVSGYKYUDIZJ","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_8","alias_value":"JJ6GKVSG","created_at":"2026-05-18T12:29:27Z"}],"graph_snapshots":[{"event_id":"sha256:05afb01517dab4903a2e618aa8560369f430efb90d79365b69bfada2d32d4721","target":"graph","created_at":"2026-05-18T01:18:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"In many adult tissues, stem cells and differentiated cells are not homogeneously distributed : stem cells are arranged in periodic \"niches\", and differentiated cells are constantly produced and migrate out of these niches. In this article, we provide a general theoretical framework to study mixtures of dividing and actively migrating particles, which we apply to biological tissues. We show in particular that the interplay between the stresses arising from active cell migration and stem cell division give rise to robust stem cell patterns. The instability of the tissue leads to spatial patterns","authors_text":"Alice Coucke, Edouard Hannezo, Jean-Fran\\c{c}ois Joanny","cross_cats":["q-bio.CB"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-18T10:49:35Z","title":"An interplay of migratory and division forces as a generic mechanism for stem cell patterns"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1512.05896","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:186ace4cdbba8bb44675eee02274b060e9ae983892a7fe43e4ef22374bccc4bc","target":"record","created_at":"2026-05-18T01:18:38Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"4d08da1dedff170998663e9a88d4aa7649d26d6eb2110b72e681fe59766f116f","cross_cats_sorted":["q-bio.CB"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2015-12-18T10:49:35Z","title_canon_sha256":"a6e3ba1e958ff2456d8dddf2b3dab93393d9b9f893b68f00890b62ff775ba195"},"schema_version":"1.0","source":{"id":"1512.05896","kind":"arxiv","version":1}},"canonical_sha256":"4a7c655646c2b141a329221e54654a269a20d0929817d5bc14c33e09fb7c6dd6","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4a7c655646c2b141a329221e54654a269a20d0929817d5bc14c33e09fb7c6dd6","first_computed_at":"2026-05-18T01:18:38.996717Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:18:38.996717Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"EEJOv1vdYeMmtVNESFYAxPBwzN9XyqJ5jXrujvQBEQLKJA5StxyV6wr/6yqHkfsoXJPu3AkDCHZzeEBLaN97BA==","signature_status":"signed_v1","signed_at":"2026-05-18T01:18:38.997206Z","signed_message":"canonical_sha256_bytes"},"source_id":"1512.05896","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:186ace4cdbba8bb44675eee02274b060e9ae983892a7fe43e4ef22374bccc4bc","sha256:05afb01517dab4903a2e618aa8560369f430efb90d79365b69bfada2d32d4721"],"state_sha256":"563bd062b9b7a639176d0360c95d5dcfde97755a74950032479cd558628a4ed5"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ypdw45pzhUxyM9Ummkt7q08r/7b+WZGVkDD+u/N4laa9tM7VHxohY50dPWG0eKFMwarPzHtJto08hCKwERdrDQ==","signed_message":"bundle_sha256_bytes","signed_at":"2026-05-31T15:13:49.938511Z","bundle_sha256":"7b832dec47926409c95c65d073cc0ece661e96c21b8f0f86e30e42a7702dd3ac"}}