{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2023:JJBZJIEGIFIYWRTDJ6N7FPNQLI","short_pith_number":"pith:JJBZJIEG","canonical_record":{"source":{"id":"2312.06159","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2023-12-11T06:51:57Z","cross_cats_sorted":["stat.CO","stat.ME"],"title_canon_sha256":"d0fe925ad150a7d3df0436ea072c43df7e5e0e76ff685900ee0c57c4dbbee41e","abstract_canon_sha256":"b8e58ce104fd587e092ab5572482c6939d71b022a66ba3ef32a669bb8244f0aa"},"schema_version":"1.0"},"canonical_sha256":"4a4394a08641518b46634f9bf2bdb05a0f3d02938d210c9b097b1859c3969732","source":{"kind":"arxiv","id":"2312.06159","version":1},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2312.06159","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"arxiv_version","alias_value":"2312.06159v1","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2312.06159","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_12","alias_value":"JJBZJIEGIFIY","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_16","alias_value":"JJBZJIEGIFIYWRTD","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_8","alias_value":"JJBZJIEG","created_at":"2026-07-05T07:22:39Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2023:JJBZJIEGIFIYWRTDJ6N7FPNQLI","target":"record","payload":{"canonical_record":{"source":{"id":"2312.06159","kind":"arxiv","version":1},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2023-12-11T06:51:57Z","cross_cats_sorted":["stat.CO","stat.ME"],"title_canon_sha256":"d0fe925ad150a7d3df0436ea072c43df7e5e0e76ff685900ee0c57c4dbbee41e","abstract_canon_sha256":"b8e58ce104fd587e092ab5572482c6939d71b022a66ba3ef32a669bb8244f0aa"},"schema_version":"1.0"},"canonical_sha256":"4a4394a08641518b46634f9bf2bdb05a0f3d02938d210c9b097b1859c3969732","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-07-05T07:22:39.637258Z","signature_b64":"t0XpK9c3G1YzFML8Z2xSvw2Xq26pGPfO9mAnzK/1/lYdB5pNZot4uolgXylO7GKXpAFUJ5xhJRmIlZpKZ4xEDg==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4a4394a08641518b46634f9bf2bdb05a0f3d02938d210c9b097b1859c3969732","last_reissued_at":"2026-07-05T07:22:39.636783Z","signature_status":"signed_v1","first_computed_at":"2026-07-05T07:22:39.636783Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"2312.06159","source_version":1,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:22:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ozXEuiLeDo5FprX4J408O/I0wGJmqZIWxDhMd6k4uiHxcLQ3O3jd9zNoWmfK5UKbaYWZ/S6cOrBSVnUOlaK1Bg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T16:36:56.118700Z"},"content_sha256":"2594f4452638ce45d6ec631a717c458fd7e0c7d616a6ffe01b4e9dfaf7aa99f1","schema_version":"1.0","event_id":"sha256:2594f4452638ce45d6ec631a717c458fd7e0c7d616a6ffe01b4e9dfaf7aa99f1"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2023:JJBZJIEGIFIYWRTDJ6N7FPNQLI","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Could dropping a few cells change the takeaways from differential expression?","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["stat.CO","stat.ME"],"primary_cat":"q-bio.QM","authors_text":"Miriam Shiffman, Ryan Giordano, Tamara Broderick","submitted_at":"2023-12-11T06:51:57Z","abstract_excerpt":"Differential expression (DE) plays a fundamental role toward illuminating the molecular mechanisms driving a difference between groups (e.g., due to treatment or disease). While any analysis is run on particular cells/samples, the intent is to generalize to future occurrences of the treatment or disease. Implicitly, this step is justified by assuming that present and future samples are independent and identically distributed from the same population. Though this assumption is always false, we hope that any deviation from the assumption is small enough that A) conclusions of the analysis still "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2312.06159","kind":"arxiv","version":1},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"integrity":{"clean":true,"summary":{"advisory":0,"critical":0,"by_detector":{},"informational":0},"endpoint":"/pith/2312.06159/integrity.json","findings":[],"available":true,"detectors_run":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938"},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-07-05T07:22:39Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"Pf/Lv0y/60vpe57j4XFTFq8kDMS+r0cCS6TtwZkNNlAD4jtP64HIsnmfqrtWCp0c27gPW5L/Jtwrwb9rA8pOAg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-08-03T16:36:56.119699Z"},"content_sha256":"17773c58690c3590152b33811b5ee2f99fef20371d6407fe391b2e64426f4dde","schema_version":"1.0","event_id":"sha256:17773c58690c3590152b33811b5ee2f99fef20371d6407fe391b2e64426f4dde"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/bundle.json","state_url":"https://pith.science/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-08-03T16:36:56Z","links":{"resolver":"https://pith.science/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI","bundle":"https://pith.science/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/bundle.json","state":"https://pith.science/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JJBZJIEGIFIYWRTDJ6N7FPNQLI/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2023:JJBZJIEGIFIYWRTDJ6N7FPNQLI","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"b8e58ce104fd587e092ab5572482c6939d71b022a66ba3ef32a669bb8244f0aa","cross_cats_sorted":["stat.CO","stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2023-12-11T06:51:57Z","title_canon_sha256":"d0fe925ad150a7d3df0436ea072c43df7e5e0e76ff685900ee0c57c4dbbee41e"},"schema_version":"1.0","source":{"id":"2312.06159","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2312.06159","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"arxiv_version","alias_value":"2312.06159v1","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2312.06159","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_12","alias_value":"JJBZJIEGIFIY","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_16","alias_value":"JJBZJIEGIFIYWRTD","created_at":"2026-07-05T07:22:39Z"},{"alias_kind":"pith_short_8","alias_value":"JJBZJIEG","created_at":"2026-07-05T07:22:39Z"}],"graph_snapshots":[{"event_id":"sha256:17773c58690c3590152b33811b5ee2f99fef20371d6407fe391b2e64426f4dde","target":"graph","created_at":"2026-07-05T07:22:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2312.06159/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Differential expression (DE) plays a fundamental role toward illuminating the molecular mechanisms driving a difference between groups (e.g., due to treatment or disease). While any analysis is run on particular cells/samples, the intent is to generalize to future occurrences of the treatment or disease. Implicitly, this step is justified by assuming that present and future samples are independent and identically distributed from the same population. Though this assumption is always false, we hope that any deviation from the assumption is small enough that A) conclusions of the analysis still ","authors_text":"Miriam Shiffman, Ryan Giordano, Tamara Broderick","cross_cats":["stat.CO","stat.ME"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2023-12-11T06:51:57Z","title":"Could dropping a few cells change the takeaways from differential expression?"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2312.06159","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:2594f4452638ce45d6ec631a717c458fd7e0c7d616a6ffe01b4e9dfaf7aa99f1","target":"record","created_at":"2026-07-05T07:22:39Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"b8e58ce104fd587e092ab5572482c6939d71b022a66ba3ef32a669bb8244f0aa","cross_cats_sorted":["stat.CO","stat.ME"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.QM","submitted_at":"2023-12-11T06:51:57Z","title_canon_sha256":"d0fe925ad150a7d3df0436ea072c43df7e5e0e76ff685900ee0c57c4dbbee41e"},"schema_version":"1.0","source":{"id":"2312.06159","kind":"arxiv","version":1}},"canonical_sha256":"4a4394a08641518b46634f9bf2bdb05a0f3d02938d210c9b097b1859c3969732","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4a4394a08641518b46634f9bf2bdb05a0f3d02938d210c9b097b1859c3969732","first_computed_at":"2026-07-05T07:22:39.636783Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T07:22:39.636783Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"t0XpK9c3G1YzFML8Z2xSvw2Xq26pGPfO9mAnzK/1/lYdB5pNZot4uolgXylO7GKXpAFUJ5xhJRmIlZpKZ4xEDg==","signature_status":"signed_v1","signed_at":"2026-07-05T07:22:39.637258Z","signed_message":"canonical_sha256_bytes"},"source_id":"2312.06159","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:2594f4452638ce45d6ec631a717c458fd7e0c7d616a6ffe01b4e9dfaf7aa99f1","sha256:17773c58690c3590152b33811b5ee2f99fef20371d6407fe391b2e64426f4dde"],"state_sha256":"1cd3560b1c76d2bf2f2fe94b66793d5c67f34b2a9b485265e298c6326f7811b8"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"POzteCjKVvwxtFkuhJAObLpR8JW54kGFsO59NDv7o8drh9BpZjMu2mBlA8Lr5WvQsGHjDXRlZu0udxuPTig5Dg==","signed_message":"bundle_sha256_bytes","signed_at":"2026-08-03T16:36:56.126417Z","bundle_sha256":"989c89dc2448f88bee30a560167cba8d3159647fea358be5386baa579ceb4f40"}}