{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2015:JK7C3ZL3WR66OAOHGBP6U6S3Z6","short_pith_number":"pith:JK7C3ZL3","canonical_record":{"source":{"id":"1509.02273","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-09-08T08:02:18Z","cross_cats_sorted":[],"title_canon_sha256":"631ec40341a451288383d77ff1e3754a676c17ef70ea51b7e2f626b44ba519b1","abstract_canon_sha256":"6f72e9fa2a868bad98d4bf24beb6a2310399b217c78961ffbdee9bd69d987100"},"schema_version":"1.0"},"canonical_sha256":"4abe2de57bb47de701c7305fea7a5bcf94010d117bfe8dfdb2b2b4348c402a98","source":{"kind":"arxiv","id":"1509.02273","version":2},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.02273","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"arxiv_version","alias_value":"1509.02273v2","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.02273","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"pith_short_12","alias_value":"JK7C3ZL3WR66","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_16","alias_value":"JK7C3ZL3WR66OAOH","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_8","alias_value":"JK7C3ZL3","created_at":"2026-05-18T12:29:27Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2015:JK7C3ZL3WR66OAOHGBP6U6S3Z6","target":"record","payload":{"canonical_record":{"source":{"id":"1509.02273","kind":"arxiv","version":2},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-09-08T08:02:18Z","cross_cats_sorted":[],"title_canon_sha256":"631ec40341a451288383d77ff1e3754a676c17ef70ea51b7e2f626b44ba519b1","abstract_canon_sha256":"6f72e9fa2a868bad98d4bf24beb6a2310399b217c78961ffbdee9bd69d987100"},"schema_version":"1.0"},"canonical_sha256":"4abe2de57bb47de701c7305fea7a5bcf94010d117bfe8dfdb2b2b4348c402a98","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T01:32:51.973299Z","signature_b64":"HruUPGS9cfh/ZpQ6kVMFBSr58eCOvgEy+0Y19FuWeTBKEgEc2Q0fsVRKHkRZEs4F1IY6xd97Rt72j9g2vz4/AQ==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4abe2de57bb47de701c7305fea7a5bcf94010d117bfe8dfdb2b2b4348c402a98","last_reissued_at":"2026-05-18T01:32:51.972864Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T01:32:51.972864Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1509.02273","source_version":2,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:32:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"+xbO0G7tmagEabJTT5ilQZRlzEProemV2KYNZ+xf/kjm0N7Fy90LRzPtoPLu3hUG3jkQGxqX3d6TJZjHrlORBg==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T20:31:17.759072Z"},"content_sha256":"d347ac4bec8aa31530fdc24a2934ab1d3c7128fc1970bbd8541d5a3d569c37ff","schema_version":"1.0","event_id":"sha256:d347ac4bec8aa31530fdc24a2934ab1d3c7128fc1970bbd8541d5a3d569c37ff"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2015:JK7C3ZL3WR66OAOHGBP6U6S3Z6","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":[],"primary_cat":"q-bio.MN","authors_text":"F. F{\\aa}k, J. J. Neher, K. D. Mc Coy, Lasser, M. Jucker, N. Dutilleul, N. Marungruang, T., T. Bolmont, T. Harach, V. Cheatham","submitted_at":"2015-09-08T08:02:18Z","abstract_excerpt":"Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known. We generated a germ-free mouse model of Alzheimer's disease and discovered a drastic reduction of cerebral Ab amyloid pathology when compared to control Alzheimer's disease animals with intestinal microbiota. Sequencing bacterial 16S rRNA from fecal samples revealed a remarkab"},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.02273","kind":"arxiv","version":2},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T01:32:51Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"sQRBYPhcxBNNHGsv6z87Ksuu5wKRmwjVgOUneVL+bhCPGAQkJ1bcbZFqxaI9nreYuLVRR2xtsPJZAaheIR3oCA==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-03T20:31:17.759431Z"},"content_sha256":"ae25c8d14b48f2d3b2f9650c05cb701679afcf36453b3206823ad293b7b097bd","schema_version":"1.0","event_id":"sha256:ae25c8d14b48f2d3b2f9650c05cb701679afcf36453b3206823ad293b7b097bd"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/bundle.json","state_url":"https://pith.science/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-03T20:31:17Z","links":{"resolver":"https://pith.science/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6","bundle":"https://pith.science/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/bundle.json","state":"https://pith.science/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JK7C3ZL3WR66OAOHGBP6U6S3Z6/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2015:JK7C3ZL3WR66OAOHGBP6U6S3Z6","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"6f72e9fa2a868bad98d4bf24beb6a2310399b217c78961ffbdee9bd69d987100","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-09-08T08:02:18Z","title_canon_sha256":"631ec40341a451288383d77ff1e3754a676c17ef70ea51b7e2f626b44ba519b1"},"schema_version":"1.0","source":{"id":"1509.02273","kind":"arxiv","version":2}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1509.02273","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"arxiv_version","alias_value":"1509.02273v2","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1509.02273","created_at":"2026-05-18T01:32:51Z"},{"alias_kind":"pith_short_12","alias_value":"JK7C3ZL3WR66","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_16","alias_value":"JK7C3ZL3WR66OAOH","created_at":"2026-05-18T12:29:27Z"},{"alias_kind":"pith_short_8","alias_value":"JK7C3ZL3","created_at":"2026-05-18T12:29:27Z"}],"graph_snapshots":[{"event_id":"sha256:ae25c8d14b48f2d3b2f9650c05cb701679afcf36453b3206823ad293b7b097bd","target":"graph","created_at":"2026-05-18T01:32:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Alzheimer's disease is the most common form of dementia in the western world, however there is no cure available for this devastating neurodegenerative disorder. Despite clinical and experimental evidence implicating the intestinal microbiota in a number of brain disorders, its impact on Alzheimer's disease is not known. We generated a germ-free mouse model of Alzheimer's disease and discovered a drastic reduction of cerebral Ab amyloid pathology when compared to control Alzheimer's disease animals with intestinal microbiota. Sequencing bacterial 16S rRNA from fecal samples revealed a remarkab","authors_text":"F. F{\\aa}k, J. J. Neher, K. D. Mc Coy, Lasser, M. Jucker, N. Dutilleul, N. Marungruang, T., T. Bolmont, T. Harach, V. Cheatham","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-09-08T08:02:18Z","title":"Reduction of Alzheimer's disease beta-amyloid pathology in the absence of gut microbiota"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1509.02273","kind":"arxiv","version":2},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:d347ac4bec8aa31530fdc24a2934ab1d3c7128fc1970bbd8541d5a3d569c37ff","target":"record","created_at":"2026-05-18T01:32:51Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"6f72e9fa2a868bad98d4bf24beb6a2310399b217c78961ffbdee9bd69d987100","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.MN","submitted_at":"2015-09-08T08:02:18Z","title_canon_sha256":"631ec40341a451288383d77ff1e3754a676c17ef70ea51b7e2f626b44ba519b1"},"schema_version":"1.0","source":{"id":"1509.02273","kind":"arxiv","version":2}},"canonical_sha256":"4abe2de57bb47de701c7305fea7a5bcf94010d117bfe8dfdb2b2b4348c402a98","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4abe2de57bb47de701c7305fea7a5bcf94010d117bfe8dfdb2b2b4348c402a98","first_computed_at":"2026-05-18T01:32:51.972864Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T01:32:51.972864Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"HruUPGS9cfh/ZpQ6kVMFBSr58eCOvgEy+0Y19FuWeTBKEgEc2Q0fsVRKHkRZEs4F1IY6xd97Rt72j9g2vz4/AQ==","signature_status":"signed_v1","signed_at":"2026-05-18T01:32:51.973299Z","signed_message":"canonical_sha256_bytes"},"source_id":"1509.02273","source_kind":"arxiv","source_version":2}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:d347ac4bec8aa31530fdc24a2934ab1d3c7128fc1970bbd8541d5a3d569c37ff","sha256:ae25c8d14b48f2d3b2f9650c05cb701679afcf36453b3206823ad293b7b097bd"],"state_sha256":"7359414b3d2f5f3b7296338008a80a88d27f124dc120f373ea5a4da128625f4d"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"jbmzpUzl0twf1WOd9l+7y6GFZsUxvUNm1sEAr55BtPqFjF/z/pSZmQhn+8nLMflt99XrrrLlI1OTfIniXRh8CA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-03T20:31:17.761331Z","bundle_sha256":"78394fd05263162c70b3039322f05838de80b0dc289bebb42448a8dc582b3b16"}}