{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2016:JLXXAM2STJA2EHR2H5ZPWKALLR","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"da36191bc0651439a2ea62be545a41cb2df2ed377ee3742605bc1977065bbb4a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2016-10-14T22:02:31Z","title_canon_sha256":"b39083530df9f1067c4e79ad03638fb8c7a8a5506e89ce21d903040c84710c7a"},"schema_version":"1.0","source":{"id":"1610.04656","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1610.04656","created_at":"2026-05-18T00:43:59Z"},{"alias_kind":"arxiv_version","alias_value":"1610.04656v1","created_at":"2026-05-18T00:43:59Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1610.04656","created_at":"2026-05-18T00:43:59Z"},{"alias_kind":"pith_short_12","alias_value":"JLXXAM2STJA2","created_at":"2026-05-18T12:30:25Z"},{"alias_kind":"pith_short_16","alias_value":"JLXXAM2STJA2EHR2","created_at":"2026-05-18T12:30:25Z"},{"alias_kind":"pith_short_8","alias_value":"JLXXAM2S","created_at":"2026-05-18T12:30:25Z"}],"graph_snapshots":[{"event_id":"sha256:4c4792079d2589f3f4bdfb9005363adc446b7fbe0c64a21adf963635169116b4","target":"graph","created_at":"2026-05-18T00:43:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Thermodynamic scaling theory, previously applied mainly to small proteins, here analyzes quantitative evolution of the titled functional network giant hub enzymes. The broad domain structure identified homologically is confirmed hydropathically using amino acid sequences only. The most surprising results concern the evolution of the tyrosine kinase globular surface roughness from avian to mammals, which is first order, compared to the evolution within mammals from rodents to humans, which is second order. The mystery of the unique amide terminal region of proto oncogene tyrosine protein kinase","authors_text":"J. C. Phillips","cross_cats":[],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2016-10-14T22:02:31Z","title":"Giant Hub Src and Syk Tyrosine Kinase Thermodynamic Profiles Recapitulate Evolution"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1610.04656","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:b80503e779b70fbb47b65363633504a5f75d31be89fa6e6b119d2bf84f9c2766","target":"record","created_at":"2026-05-18T00:43:59Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"da36191bc0651439a2ea62be545a41cb2df2ed377ee3742605bc1977065bbb4a","cross_cats_sorted":[],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"q-bio.OT","submitted_at":"2016-10-14T22:02:31Z","title_canon_sha256":"b39083530df9f1067c4e79ad03638fb8c7a8a5506e89ce21d903040c84710c7a"},"schema_version":"1.0","source":{"id":"1610.04656","kind":"arxiv","version":1}},"canonical_sha256":"4aef7033529a41a21e3a3f72fb280b5c78af3b451edac3c19ce34674ad809d8a","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4aef7033529a41a21e3a3f72fb280b5c78af3b451edac3c19ce34674ad809d8a","first_computed_at":"2026-05-18T00:43:59.749909Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T00:43:59.749909Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"oacfEgqYvBWP4+F4dHQsVX67p6RH/s8nIC+NcgUc8+iLSSgdlSjWi1qM1NhAFHrgBAXNvX9yBheYImXnhnKmDQ==","signature_status":"signed_v1","signed_at":"2026-05-18T00:43:59.750672Z","signed_message":"canonical_sha256_bytes"},"source_id":"1610.04656","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:b80503e779b70fbb47b65363633504a5f75d31be89fa6e6b119d2bf84f9c2766","sha256:4c4792079d2589f3f4bdfb9005363adc446b7fbe0c64a21adf963635169116b4"],"state_sha256":"b9a659fc3111810a09f3341ffcc21013f3558f435672616539b858020afe7acb"}