{"bundle_type":"pith_open_graph_bundle","bundle_version":"1.0","pith_number":"pith:2011:JNRN7SWWBCOYE4CG3ATKVODNTW","short_pith_number":"pith:JNRN7SWW","canonical_record":{"source":{"id":"1109.1155","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-09-06T12:38:02Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"title_canon_sha256":"9d688ceaee43ae9931c28ab58eeba4142305103e45d51e43033b89d0606035d5","abstract_canon_sha256":"289a4a2bdf8a19480e6be0ca5b45185500dab21c8249f8f83ff354c76a2d491c"},"schema_version":"1.0"},"canonical_sha256":"4b62dfcad6089d827046d826aab86d9dacdcb402f28eb0fa80a26a150b6e769d","source":{"kind":"arxiv","id":"1109.1155","version":3},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1109.1155","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"arxiv_version","alias_value":"1109.1155v3","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1109.1155","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"pith_short_12","alias_value":"JNRN7SWWBCOY","created_at":"2026-05-18T12:26:32Z"},{"alias_kind":"pith_short_16","alias_value":"JNRN7SWWBCOYE4CG","created_at":"2026-05-18T12:26:32Z"},{"alias_kind":"pith_short_8","alias_value":"JNRN7SWW","created_at":"2026-05-18T12:26:32Z"}],"events":[{"event_type":"record_created","subject_pith_number":"pith:2011:JNRN7SWWBCOYE4CG3ATKVODNTW","target":"record","payload":{"canonical_record":{"source":{"id":"1109.1155","kind":"arxiv","version":3},"metadata":{"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-09-06T12:38:02Z","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"title_canon_sha256":"9d688ceaee43ae9931c28ab58eeba4142305103e45d51e43033b89d0606035d5","abstract_canon_sha256":"289a4a2bdf8a19480e6be0ca5b45185500dab21c8249f8f83ff354c76a2d491c"},"schema_version":"1.0"},"canonical_sha256":"4b62dfcad6089d827046d826aab86d9dacdcb402f28eb0fa80a26a150b6e769d","receipt":{"kind":"pith_receipt","key_id":"pith-v1-2026-05","algorithm":"ed25519","signed_at":"2026-05-18T04:08:23.841157Z","signature_b64":"etQn4Vg8UjpFPXrUZ1R9EWb4U8Gw5zcyd23HdJlraK23Af11250Kv5jhG8KnicQeyKKmj3eQYd4vXcg2lhUIAA==","signed_message":"canonical_sha256_bytes","builder_version":"pith-number-builder-2026-05-17-v1","receipt_version":"0.3","canonical_sha256":"4b62dfcad6089d827046d826aab86d9dacdcb402f28eb0fa80a26a150b6e769d","last_reissued_at":"2026-05-18T04:08:23.840676Z","signature_status":"signed_v1","first_computed_at":"2026-05-18T04:08:23.840676Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"source_kind":"arxiv","source_id":"1109.1155","source_version":3,"attestation_state":"computed"},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:08:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"L0xlIGyS3gmXiGbPzaVqLitkDioEhyULF27CIeu/KLwdw7zQVKi8PPEEgJ2InyaZ6DQCpTkyJLPBksnONTIIBw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T01:24:20.706784Z"},"content_sha256":"c5f2c7559b4d73d0f3acc1348e66a174d4f5e6461926660d268f00277dfa90ad","schema_version":"1.0","event_id":"sha256:c5f2c7559b4d73d0f3acc1348e66a174d4f5e6461926660d268f00277dfa90ad"},{"event_type":"graph_snapshot","subject_pith_number":"pith:2011:JNRN7SWWBCOYE4CG3ATKVODNTW","target":"graph","payload":{"graph_snapshot":{"paper":{"title":"Crowding of molecular motors determines microtubule depolymerization","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","headline":"","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"primary_cat":"physics.bio-ph","authors_text":"Anna Melbinger, Erwin Frey, Louis Reese","submitted_at":"2011-09-06T12:38:02Z","abstract_excerpt":"Assembly and disassembly dynamics of microtubules (MTs) is tightly controlled by MT associated proteins. Here, we investigate how plus-end-directed depolymerases of the kinesin-8 family regulate MT depolymerization dynamics. Employing an individual-based model, we reproduce experimental findings. Moreover, crowding is identified as the key regulatory mechanism of depolymerization dynamics. Our analysis gives two qualitatively distinct regimes. For motor densities above a particular threshold, a macroscopic traffic jam emerges at the plus-end and the MT dynamics become independent of the motor "},"claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1109.1155","kind":"arxiv","version":3},"verdict":{"id":null,"model_set":{},"created_at":null,"strongest_claim":"","one_line_summary":"","pipeline_version":null,"weakest_assumption":"","pith_extraction_headline":""},"references":{"count":0,"sample":[],"resolved_work":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","internal_anchors":0},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"author_claims":{"count":0,"strong_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"builder_version":"pith-number-builder-2026-05-17-v1"},"verdict_id":null},"signer":{"signer_id":"pith.science","signer_type":"pith_registry","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54"},"created_at":"2026-05-18T04:08:23Z","supersedes":[],"prev_event":null,"signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"OsTcLwNutYrRd5qOz8mJ0ImcxU56BxyrdkKsRQKw/smUFipC/F0Bv2uTtqeMG4HPoJYTRY1SHsV5stpvHZSvAw==","signed_message":"open_graph_event_sha256_bytes","signed_at":"2026-06-12T01:24:20.707441Z"},"content_sha256":"5fe0d8764f9238d0ef49a227bebd8d5915a163bf61854cdfaa18f0990630e27a","schema_version":"1.0","event_id":"sha256:5fe0d8764f9238d0ef49a227bebd8d5915a163bf61854cdfaa18f0990630e27a"}],"timestamp_proofs":[],"mirror_hints":[{"mirror_type":"https","name":"Pith Resolver","base_url":"https://pith.science","bundle_url":"https://pith.science/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/bundle.json","state_url":"https://pith.science/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/state.json","well_known_bundle_url":"https://pith.science/.well-known/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/bundle.json","status":"primary"}],"public_keys":[{"key_id":"pith-v1-2026-05","algorithm":"ed25519","format":"raw","public_key_b64":"stVStoiQhXFxp4s2pdzPNoqVNBMojDU/fJ2db5S3CbM=","public_key_hex":"b2d552b68890857171a78b36a5dccf368a953413288c353f7c9d9d6f94b709b3","fingerprint_sha256_b32_first128bits":"RVFV5Z2OI2J3ZUO7ERDEBCYNKS","fingerprint_sha256_hex":"8d4b5ee74e4693bcd1df2446408b0d54","rotates_at":null,"url":"https://pith.science/pith-signing-key.json","notes":"Pith uses this Ed25519 key to sign canonical record SHA-256 digests. Verify with: ed25519_verify(public_key, message=canonical_sha256_bytes, signature=base64decode(signature_b64))."}],"merge_version":"pith-open-graph-merge-v1","built_at":"2026-06-12T01:24:20Z","links":{"resolver":"https://pith.science/pith/JNRN7SWWBCOYE4CG3ATKVODNTW","bundle":"https://pith.science/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/bundle.json","state":"https://pith.science/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/state.json","well_known_bundle":"https://pith.science/.well-known/pith/JNRN7SWWBCOYE4CG3ATKVODNTW/bundle.json"},"state":{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2011:JNRN7SWWBCOYE4CG3ATKVODNTW","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"289a4a2bdf8a19480e6be0ca5b45185500dab21c8249f8f83ff354c76a2d491c","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-09-06T12:38:02Z","title_canon_sha256":"9d688ceaee43ae9931c28ab58eeba4142305103e45d51e43033b89d0606035d5"},"schema_version":"1.0","source":{"id":"1109.1155","kind":"arxiv","version":3}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"1109.1155","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"arxiv_version","alias_value":"1109.1155v3","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.1109.1155","created_at":"2026-05-18T04:08:23Z"},{"alias_kind":"pith_short_12","alias_value":"JNRN7SWWBCOY","created_at":"2026-05-18T12:26:32Z"},{"alias_kind":"pith_short_16","alias_value":"JNRN7SWWBCOYE4CG","created_at":"2026-05-18T12:26:32Z"},{"alias_kind":"pith_short_8","alias_value":"JNRN7SWW","created_at":"2026-05-18T12:26:32Z"}],"graph_snapshots":[{"event_id":"sha256:5fe0d8764f9238d0ef49a227bebd8d5915a163bf61854cdfaa18f0990630e27a","target":"graph","created_at":"2026-05-18T04:08:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"paper":{"abstract_excerpt":"Assembly and disassembly dynamics of microtubules (MTs) is tightly controlled by MT associated proteins. Here, we investigate how plus-end-directed depolymerases of the kinesin-8 family regulate MT depolymerization dynamics. Employing an individual-based model, we reproduce experimental findings. Moreover, crowding is identified as the key regulatory mechanism of depolymerization dynamics. Our analysis gives two qualitatively distinct regimes. For motor densities above a particular threshold, a macroscopic traffic jam emerges at the plus-end and the MT dynamics become independent of the motor ","authors_text":"Anna Melbinger, Erwin Frey, Louis Reese","cross_cats":["cond-mat.stat-mech","q-bio.SC"],"headline":"","license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-09-06T12:38:02Z","title":"Crowding of molecular motors determines microtubule depolymerization"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"1109.1155","kind":"arxiv","version":3},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:c5f2c7559b4d73d0f3acc1348e66a174d4f5e6461926660d268f00277dfa90ad","target":"record","created_at":"2026-05-18T04:08:23Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"289a4a2bdf8a19480e6be0ca5b45185500dab21c8249f8f83ff354c76a2d491c","cross_cats_sorted":["cond-mat.stat-mech","q-bio.SC"],"license":"http://arxiv.org/licenses/nonexclusive-distrib/1.0/","primary_cat":"physics.bio-ph","submitted_at":"2011-09-06T12:38:02Z","title_canon_sha256":"9d688ceaee43ae9931c28ab58eeba4142305103e45d51e43033b89d0606035d5"},"schema_version":"1.0","source":{"id":"1109.1155","kind":"arxiv","version":3}},"canonical_sha256":"4b62dfcad6089d827046d826aab86d9dacdcb402f28eb0fa80a26a150b6e769d","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4b62dfcad6089d827046d826aab86d9dacdcb402f28eb0fa80a26a150b6e769d","first_computed_at":"2026-05-18T04:08:23.840676Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-05-18T04:08:23.840676Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"etQn4Vg8UjpFPXrUZ1R9EWb4U8Gw5zcyd23HdJlraK23Af11250Kv5jhG8KnicQeyKKmj3eQYd4vXcg2lhUIAA==","signature_status":"signed_v1","signed_at":"2026-05-18T04:08:23.841157Z","signed_message":"canonical_sha256_bytes"},"source_id":"1109.1155","source_kind":"arxiv","source_version":3}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:c5f2c7559b4d73d0f3acc1348e66a174d4f5e6461926660d268f00277dfa90ad","sha256:5fe0d8764f9238d0ef49a227bebd8d5915a163bf61854cdfaa18f0990630e27a"],"state_sha256":"08b5139e3616593c4e79a1aa3ee67371931d697b81599c4c2a2be13bf3955dee"},"bundle_signature":{"signature_status":"signed_v1","algorithm":"ed25519","key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signature_b64":"ZnZZ2+5tnspTyEMED8wk41ZrsJNMoCVjwZ/QitZsgk33as08c+cP5CvY5EcmnsBaiPZyY5lNbW9YheYgGsgzBA==","signed_message":"bundle_sha256_bytes","signed_at":"2026-06-12T01:24:20.710043Z","bundle_sha256":"197f981db424772fc948d5d7939e88998aa51ad38a8daa51f4d9eac10053be18"}}