{"state_type":"pith_open_graph_state","state_version":"1.0","pith_number":"pith:2020:JOVVO54UJ4DWACJS35FEI2BP2M","merge_version":"pith-open-graph-merge-v1","event_count":2,"valid_event_count":2,"invalid_event_count":0,"equivocation_count":0,"current":{"canonical_record":{"metadata":{"abstract_canon_sha256":"8030f8ec705dc331aeb5cb76de2af117b53c40a6c517e6c104c5a61c193c52f2","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2020-05-27T14:42:09Z","title_canon_sha256":"f85d4547bd919a46d7fe5bf028021de80b41675ec3a96905606b859ac1c4e603"},"schema_version":"1.0","source":{"id":"2005.13389","kind":"arxiv","version":1}},"source_aliases":[{"alias_kind":"arxiv","alias_value":"2005.13389","created_at":"2026-07-05T01:06:15Z"},{"alias_kind":"arxiv_version","alias_value":"2005.13389v1","created_at":"2026-07-05T01:06:15Z"},{"alias_kind":"doi","alias_value":"10.48550/arxiv.2005.13389","created_at":"2026-07-05T01:06:15Z"},{"alias_kind":"pith_short_12","alias_value":"JOVVO54UJ4DW","created_at":"2026-07-05T01:06:15Z"},{"alias_kind":"pith_short_16","alias_value":"JOVVO54UJ4DWACJS","created_at":"2026-07-05T01:06:15Z"},{"alias_kind":"pith_short_8","alias_value":"JOVVO54U","created_at":"2026-07-05T01:06:15Z"}],"graph_snapshots":[{"event_id":"sha256:0e773631490a424d03751bf1a7264b797dd9d288f96cbb86c3a37da3468abdbe","target":"graph","created_at":"2026-07-05T01:06:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"graph_snapshot":{"author_claims":{"count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57","strong_count":0},"builder_version":"pith-number-builder-2026-05-17-v1","claims":{"count":0,"items":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"formal_canon":{"evidence_count":0,"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"integrity":{"available":true,"clean":true,"detectors_run":[],"endpoint":"/pith/2005.13389/integrity.json","findings":[],"snapshot_sha256":"c28c3603d3b5d939e8dc4c7e95fa8dfce3d595e45f758748cecf8e644a296938","summary":{"advisory":0,"by_detector":{},"critical":0,"informational":0}},"paper":{"abstract_excerpt":"Prevention of protein aggregation and thus stabilization of proteins has large biological and biotechnological implications. Here, we show that inhibition of amyloid-like aggregates is possible in stoichiometric conjugates of polymer surfactant and bovine serum albumin (BSA) chosen as a model protein. We investigate using a combination of Thioflavin-T fluorescence spectroscopy, dynamic light scattering and FTIR spectroscopy the aggregation behavior in polymer surfactant modified and unmodified (native) BSA solutions. The BSA-polymer surfactant conjugates are stable up to 5 days under aggregati","authors_text":"Anasua Mukhopadhyay, David A. King, Erika Eiser, Iliya D. Stoev, Kamendra P. Sharma","cross_cats":["cond-mat.soft","physics.bio-ph"],"headline":"","license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2020-05-27T14:42:09Z","title":"Inhibiting amyloid-like aggregation through bio-conjugation of proteins with polymer surfactant"},"references":{"count":0,"internal_anchors":0,"resolved_work":0,"sample":[],"snapshot_sha256":"258153158e38e3291e3d48162225fcdb2d5a3ed65a07baac614ab91432fd4f57"},"source":{"id":"2005.13389","kind":"arxiv","version":1},"verdict":{"created_at":null,"id":null,"model_set":{},"one_line_summary":"","pipeline_version":null,"pith_extraction_headline":"","strongest_claim":"","weakest_assumption":""}},"verdict_id":null}}],"author_attestations":[],"timestamp_anchors":[],"storage_attestations":[],"citation_signatures":[],"replication_records":[],"corrections":[],"mirror_hints":[],"record_created":{"event_id":"sha256:19c115712bec749290f1d030f71749aa4899424838e79247ea90167bbee0c2e2","target":"record","created_at":"2026-07-05T01:06:15Z","signer":{"key_id":"pith-v1-2026-05","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","signer_id":"pith.science","signer_type":"pith_registry"},"payload":{"attestation_state":"computed","canonical_record":{"metadata":{"abstract_canon_sha256":"8030f8ec705dc331aeb5cb76de2af117b53c40a6c517e6c104c5a61c193c52f2","cross_cats_sorted":["cond-mat.soft","physics.bio-ph"],"license":"http://creativecommons.org/licenses/by/4.0/","primary_cat":"q-bio.BM","submitted_at":"2020-05-27T14:42:09Z","title_canon_sha256":"f85d4547bd919a46d7fe5bf028021de80b41675ec3a96905606b859ac1c4e603"},"schema_version":"1.0","source":{"id":"2005.13389","kind":"arxiv","version":1}},"canonical_sha256":"4bab5777944f07600932df4a44682fd3396f12b3bfb22b4196c884fbfbbe2b6e","receipt":{"algorithm":"ed25519","builder_version":"pith-number-builder-2026-05-17-v1","canonical_sha256":"4bab5777944f07600932df4a44682fd3396f12b3bfb22b4196c884fbfbbe2b6e","first_computed_at":"2026-07-05T01:06:15.529113Z","key_id":"pith-v1-2026-05","kind":"pith_receipt","last_reissued_at":"2026-07-05T01:06:15.529113Z","public_key_fingerprint":"8d4b5ee74e4693bcd1df2446408b0d54","receipt_version":"0.3","signature_b64":"GVhUPJQ7jvA45H+u04QZiB5pAtiivrx/rQrlatB8f9A2KHglw9AcVg4CBHWyiUw5xMjVdvsDpLjwXXy92cH6Cw==","signature_status":"signed_v1","signed_at":"2026-07-05T01:06:15.529674Z","signed_message":"canonical_sha256_bytes"},"source_id":"2005.13389","source_kind":"arxiv","source_version":1}}},"equivocations":[],"invalid_events":[],"applied_event_ids":["sha256:19c115712bec749290f1d030f71749aa4899424838e79247ea90167bbee0c2e2","sha256:0e773631490a424d03751bf1a7264b797dd9d288f96cbb86c3a37da3468abdbe"],"state_sha256":"e40d18a8088236e6f91ea7c043038ea1651f156cda194f5baac7ba21a96b40bc"}